The formation and recall of memories are fundamental aspects of life and help preserve the complex collection of experiences that provide us with a sense of identity and autonomy. Scientists have recently started to investigate pharmacological agents that inhibit or “dampen” the strength of memory formation and recall. The development of these memory-dampening agents has been investigated for the treatment of posttraumatic stress disorder (PTSD). Currently, these agents are being tested in multicenter clinical trials and will likely soon be approved for the treatment of PTSD. With advancements in technology, more targeted memory-dampening techniques may be developed in the future. Accessibility to these agents will inevitably affect one's sense of identity and also one's sense of autonomy. Therefore, it is essential that the legal and ethical implications of using these agents be examined for governments and courts to appropriately address issues that may emerge.
Anderson, A.K., Wais, P.E., & Gabrieli, J.D. (2006). Emotion enhances remembrance of neutral events past. Proceedings of the National Academy of Sciences of the United States of America, 103(5), 1599-1604.
2.
Baddeley, A.D. (1992). What is autobiographical memory? In M. A. Conway, D. C. Rubin, H. Spinnler, & W. A. Wagenaar (Eds.), Theoretical perspectives on autobiographical memory (pp. 13-29). Dordrecht, the Netherlands: Kluwer Academic.
3.
Beike, D.R., Lampinen, J.M., & Behrend, D.A. (2004). The self and memory. New York : Psychology Press.
4.
Bernsten, D. (2001). Involuntary memories of emotional events. Do memories of traumas and extremely unhappy events differ? Applied Cognitive Psychology, 15, 135-158.
5.
Bernsten, D., Willert, M., & Rubin, D.C. (2005). Splintered memories or vivid landmarks? Qualities and organization of traumatic memories with and without PTSD. Applied Cognitive Psychology, 17, 675-693.
6.
Blank, H. (1998). Memory states and memory tasks: An integrative framework for eyewitness memory and suggestibility. Memory , 6(5), 481-529.
7.
Blumenthal, J.A., Madden, D.J., Krantz, D.S., Light, K.C., McKee, D.C., Ekelund, L.G., et al. (1988). Short-term behavioral effects of beta-adrenergic medications in men with mild hypertension. Clinical Pharmacology and Therapeutics, 43(4), 429-435.
8.
Breger, L. (1974). From instinct to identity: The development of personality. Englewood Cliffs, NJ: Prentice Hall.
9.
Bremner, J.D. (2002). Does stress damage the brain?New York: Norton.
10.
Breslau, N., Davis, G.C., Andreski, P., & Peterson, E. (1991). Traumatic events and posttraumatic stress disorder in an urban population of young adults. Archives of General Psychiatry, 48(3), 216-222.
11.
Brewin, C.R. (2001). A cognitive neuroscience account of posttraumatic stress disorder and its treatment. Behaviour Research and Therapy, 39(4), 373-393.
12.
Brunet, A., Orr, S.P., Tremblay, J., Robertson, K., Nader, K., & Pitman, R.K. (2008). Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorder. Journal of Psychiatric Research, 42(6), 503-506
13.
Conway, M.A., & Pleydell-Pearce, C.W. (2000). The construction of autobiographical memories in the self-memory system. Psychological Review, 107(2), 261-288.
14.
Conway, M.A., Rubin, D.C., Spinnler, H., & Wagenaar, W.A. (1992). Theoretical perspectives on autobiographical memory. Dordrecht, the Netherlands: Kluwer Academic.
15.
Dallaire, R.A. (2003). Shake hands with the devil: The failure of humanity in Rwanda. Toronto: Random House Canada.
16.
Debiec, J., & LeDoux, J.E. (2006). Noradrenergic signaling in the amygdala contributes to the reconsolidation of fear memory: Treatment implications for PTSD. Annals of the New York Academy of Sciences , 1071, 521-524.
17.
Doe, J. (2003). The story of Jane Doe: A book about rape. Toronto: Random House Canada.
18.
Doiron v. Haché (2003 NBQB 26).
19.
Doyere, V., Debiec, J., Monfils, M.H., Schafe, G.E., & LeDoux, J.E. (2007). Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala. Nature Neuroscience, 10(4), 414-416.
20.
Emilien, G., Penasse, C., Charles, G., Martin, D., Lasseaux, L., & Waltregny, A. (2000). Post-traumatic stress disorder: Hypotheses from clinical neuropsychology and psychopharmacology research. International Journal of Psychiatry in Clinical Practice, 4, 3-18.
21.
Farah, M.J. (2004). Neuroethics: A guide for the perplexed. Cerebrum, 6(4), 29-38.
22.
Farah, M.J., Illes, J., Cook-Deegan, R., Gardner, H., Kandel, E., King, P., et al. (2004). Neurocognitive enhancement: What can we do and what should we do? Nature Reviews: Neuroscience, 5(5), 421-425.
23.
Ferry, B., Roozendaal, B., & McGaugh, J.L. (1999). Role of norepinephrine in mediating stress hormone regulation of long-term memory storage: A critical involvement of the amygdala . Biological Psychiatry, 46(9), 1140-1152.
24.
Flamenbaum, W. (1989). Beta-blockers and hypertension. American Journal of Hypertension, 2, 86S-89S.
25.
Foa, E.B., Dancu, C.V., Hembree, E.A., Jaycox, L.H., Meadows, E.A., & Street, G.P. (1999). A comparison of exposure therapy, stress inoculation training, and their combination for reducing posttraumatic stress disorder in female assault victims. Journal of Consulting and Clinical Psychology, 67(2), 194-200.
26.
Fraser v. Beck, O.J. No. 2263 (Ont.S.C.J) (2006).
27.
Frcka, G., & Lader, M. (1988). Psychotropic effects of repeated doses of enalapril, propranolol and atenolol in normal subjects. British Journal of Clinical Pharmacology, 25(1), 67-73.
28.
Friedman, M.J. (2005). Pharmacological approaches to cognitive deficits associated with PTSD. In J. J. Vasterling & C. R. Brewin (Eds.), Neuropsychology of PTSD (pp. 292-326). New York: Guilford.
29.
Glannon, W. (2006). Psychopharmacology and memory. Journal of Medical Ethics, 32, 74-78.
30.
Haber, R.N., & Haber, L. (2000). Experiencing, remembering and reporting events . Psychology, Public Policy, and Law, 6(4), 1057-1097.
31.
Hammond, K.R. (2000). Judgments under stress. New York: Oxford University Press.
32.
Hatfield, T., & McGaugh, J.L. (1999). Norepinephrine infused into the basolateral amygdala posttraining enhances retention in a spatial water maze task. Neurobiology of Learning and Memory, 71(2), 232-239.
33.
Health Care Consent Act (S.O. 1996, c. 2, Sch. A).
34.
Hui, G.K., Figueroa, I.R., Poytress, B.S., Roozendaal, B., McGaugh, J.L., & Weinberger, N.M. (2004). Memory enhancement of classical fear conditioning by post-training injections of corticosterone in rats. Neurobiology of Learning and Memory, 81(1), 67-74.
35.
Jane Doe v. Metropolitan Toronto (Municipality) Commissioners of Police, O.J. No. 2681 (Ont.C.J) (1998).
36.
Illes, J. (2007). Not forgetting forgetting. American Journal of Bioethics, 7(9), 1-2.
37.
Kessler, R.C., Sonnega, A., Bromet, E., Hughes, M., & Nelson, C.B. (1995). Posttraumatic stress disorder in the National Comorbidity Survey. Archives of General Psychiatry, 52(12), 1048-1060.
38.
LaBar, K.S., & Cabeza, R. (2006). Cognitive neuroscience of emotional memory. Nature Reviews: Neuroscience, 7(1), 54-64.
39.
Lehrer, P.M., Rosen, R.C., Kostis, J.B., & Greenfield, D. (1987). Treating stage fright in musicians: The use of beta blockers. New Jersey Medicine, 84(1), 27-33.
40.
Lindsay, R.C.L., Wells, G.L., & O'Connor, F.J. (1989). Mock juror belief of accurate and inaccurate eyewitnesses: A replication and extension. Law and Human Behavior, 13, 333-339.
41.
Marantz Henig, R. (2004, April 4). The quest to forget. The New York Times Magazine, pp. 34-36.
42.
Markowitsch, H.J. (2003). Memory: Disturbances and therapy. In T. Brant, L. Caplan, J. Dichigans, H. C. Diener , C. Kennard (Eds.), Neurological disorders: Course and treatment (2nd ed., pp. 287-302). San Diego, CA: Academic Press.
43.
Marks, I., Lovell, K., Noshirvani, H., Livanou, M., & Thrasher, S. (1998). Treatment of posttraumatic stress disorder by exposure and/or cognitive restructuring: A controlled study. Archives of General Psychiatry, 55(4), 317-325.
44.
McAdams, D.P. (1993). The stories we live by: Personal myths and the making of the self. New York: Morrow .
45.
McAdams, D.P. (2001). The psychology of life stories. Review of General Psychology, 5(2), 100-122.
46.
McAinsh, J., & Cruickshank, J.M. (1990). Beta-blockers and central nervous system side effects. Pharmacology & Therapeutics , 46(2), 163-197.
47.
Mercier v. Royal & Sun Alliance Insurance Co. of Canada, O.J. No. 1233 (Ont.S.C.J) (2003).
48.
McGaugh, J.L. (2006). Make mild moments memorable: Add a little arousal . Trends in Cognitive Science, 10(8), 345-347.
49.
Muldoon, M.F., Manuck, S.B., Shapiro, A.P., & Waldstein, S.R. (1991). Neurobehavioral effects of antihypertensive medications. Journal of Hypertension, 9(6), 549-559.
50.
Neftel, K.A., Adler, R.H., Kappeli, L., Rossi, M., Dolder, M., Kaser, H.E., et al. (1982). Stage fright in musicians: A model illustrating the effect of beta blockers. Psychosomatic Medicine, 44(5), 461-469.
51.
Paciocco, D.M. (2005). The law of evidence. Toronto , Canada: Irwin Law.
52.
Parker, L.A. (2003). Taste avoidance and taste aversion: Evidence for two different processes. Learning & Behavior, 31(2), 165-172.
53.
Patterson, B.W. (2004). The "tyranny of the eyewitness." Law & Psychology Review, 28, 195-203.
54.
Pitman, R.K., Sanders, K.M., Zusman, R.M., Healy, A.R., Cheema, F., Lasko, N.B., et al. (2002). Pilot study of secondary prevention of posttraumatic stress disorder with propranolol. Biological Psychiatry, 51(2), 189-192.
55.
Prichard, B.N., McDevitt, D.G., & Shanks, R.G. (1976). Uses of beta-adrenoceptor blocking drugs. Journal of the Royal College of Physicians of London, 11(1), 35-57.
56.
Raz, J. (1998). The morality of freedom. Oxford , UK: Oxford University Press.
57.
Resick, P.A., Nishith, P., Weaver, T.L., Astin, M.C., & Feuer, C.A. (2002). A comparison of cognitive-processing therapy with prolonged exposure and a waiting condition for the treatment of chronic posttraumatic stress disorder in female rape victims. Journal of Consulting and Clinical Psychology, 70(4), 867-879.
58.
Shalev, A.Y. (2000). Measuring outcome in posttraumatic stress disorder . Journal of Clinical Psychiatry, 61(Suppl. 5), 33-39.
59.
Strange, B.A., & Dolan, R.J. (2004). Beta-adrenergic modulation of emotional memory-evoked human amygdala and hippocampal responses. Proceedings of the National Academy of Sciences of the United States of America, 101(31), 11454-11458.
60.
Strange, B.A., Hurlemann, R., & Dolan, R.J. (2003). An emotion-induced retrograde amnesia in humans is amygdala-and beta-adrenergic-dependent. Proceedings of the National Academy of Sciences of the United States of America, 100(23), 13626-13631.
61.
Sutherland, K., & Bryant, R.A. (2005). Self-defining memories in post-traumatic stress disorder. British Journal of Clinical Psychology, 44, 591-598.
62.
Thompson, C.P., Herrmann, D.J., Bruce, D., Read, J.D., Payne, D.G., & Toglia, M.P. (1998). Autobiographical memory: Theoretical and applied perspectives. Mahwah, NJ: Lawrence Erlbaum.
63.
Tulving, E., & Markowitsch, H.J. (1998). Episodic and declarative memory: Role of the hippocampus. Hippocampus, 8(3), 198-204.
64.
Vaiva, G., Ducrocq, F., Jezequel, K., Averland, B., Lestavel, P., Brunet, A., & Marmar, C.R. (2003). Immediate treatment with propranolol decreases posttraumatic stress disorder two months after trauma. Biological Psychiatry, 54(9), 947-949.
65.
van der Kolk, B.A., Dreyfuss, D., Michaels, M., Shera, D., Berkowitz, R., Fisler, R., et al. (1994). Fluoxetine in posttraumatic stress disorder . Journal of Clinical Psychiatry, 55(12), 517-522.
66.
van Stegeren, A.H., Goekoop, R., Everaerd, W., Scheltens, P., Barkhof, F., Kuijer, J.P., et al. (2005). Noradrenaline mediates amygdala activation in men and women during encoding of emotional material. Neuroimage, 24(3), 898-909.
67.
Vasterling, J.J., & Brewin, C.R. (2005). Neuropsychology of PTSD. New York: Guilford.
68.
Waldstein, S.R., Manuck, S.B., Ryan, C.M., & Muldoon, M.F. (1991). Neuropsychological correlates of hypertension: Review and methodologic considerations. Psychological Bulletin , 110(3), 451-468.
69.
Welzer, H., & Markowitsch, H.J. (2005). Towards a bio-psycho-social model of autobiographical memory. Memory, 13(1), 63-78.
70.
Wheeler, M.A., Stuss, D.T., & Tulving, E. (1997). Toward a theory of episodic memory: The frontal lobes and autonoetic consciousness. Psychological Bulletin , 121(3), 331-354.
71.
Wortsman, J. (2002). Role of epinephrine in acute stress. Endocrinology Metabolism Clinics of North America, 31(1), 79-106.
72.
Yule, W. (2001). Posttraumatic stress disorder in the general population and in children. Journal of Clinical Psychiatry, 62(Suppl. 17), 23-28.
