Phosphatidylinositol 3 kinase (PI 3-kinase) is an important enzyme that is involved in the regulation of a variety of biological processes such as apoptosis, cell division, and ion channel activity and can play a role in the pathological development of a number of diseases, including AIDS and cancer. The authors’ data indicate that external qi of Yan Xin Life Science Technology (YXLST) can modulate enzyme activity in two directions. Within a time window of 3 days of the initial emission of external qi of YXLST, PI 3-kinase activity was restored in an outdated enzyme sample that had lost activity, and PI 3-kinase activity was suppressed in a freshly purified sample relative to an untreated control sample so that its activity was nearly undetectable. The data presented are consistent with the hypothesis that external qi of YXLST can alter molecular events. The uniqueness of this and other observations mandates further study.
Arcaro, A., Volinia, S., Zvelebil, M. J., Stein, R., Watton, S. J., Layton, M. J., et al. (1998). Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity. Journal of Biological Chemistry, 273(49), 33082-33090.
2.
Berti, L., Kellerer, M., Capp, E., & Haring, H. U.(1997). Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: Evidence for a P13-kinase mediated effect. Diabetologia, 40(5), 606-609.
3.
Dhand, R., Hiles, I., Panayotou, G., Roche, S., Fry, M. J., Gout, I., et al. (1994). PI 3-kinase is a dual specificity enzyme: Autoregulation by an intrinsic protein-serine kinase activity. EMBO Journal, 13(3), 522-533.
4.
Duronio, V., Scheid, M. P., & Ettinger, S. (1998). Downstreamsignalling events regulated by phosphatidylinositol 3-kinase activity. Cellular Signalling, 10(4), 233-239.
5.
Guo, T. (1988). Chinese superman. Chengdu, Sichuan: Sichuan Arts and Literature Press.
6.
Jones, A. T., & Clague, M. J. (1995). Phosphatidylinositol 3-kinase activity is required for early endosome fusion. Biochemical Journal, 311(1), 31-34.
7.
Ko, H. (317). Pao Pu Tzu (The Philosopher Who Embraces Simplicity). 1990 edition, Shanghai, China: Shanghai Ancient Books Press.
8.
Li, L. (Ed.). (1988). Yan Xin Qigong phenomena. Beijing, China: Beijing Industrial University Press.
9.
Li, S., Sun, M., Dai, Z., Zhang, P., Meng, G., Liu, Z., et al. (1990). Experimental studies on the feasibility of improving industrial strains with qigong treatment. Ziran Zazhi, 13, 791-801.
10.
Lu, Z. (1997). Scientific qigong exploration—The wonders and mysteries of qi. Malvern, PA: Amber Leaf.
11.
Ming, Z. (1988). The new frontiers of modern sciences—An introduction to Yan Xin Qigong. Beijing, China: Xinhua Press.
12.
Stein, R. C., & Waterfield, M. D. (2000). PI3-kinase inhibition: A target for drug development?Molecular Medicine Today, 6(9),347-357.
13.
Xin, Y., Fong, Y. T., Wolf, G., Wolf, D., & Cao, W. (2001). Protective effect of XY99-5038 on hydrogen peroxide induced cell death in cultured retinal neurons. Life Sciences, 69, 289-299.
14.
Yan, X. (Ed.). (in preparation). Proceedings of 2001 Harvard-MIT Yan Xin Life Science Technology research conference. New-town, PA: Amber Leaf.
15.
Yan, X., Fong, Y.T., Jiang, H., Zhang, C., Hu, D., Shen, H., et al. (2002a, June). XY-S induces apoptosis in colorectal cancer cells independently of p53-status but has no significant cytotoxicity to normal human cells. Paper presented at the 4th International Conference: Perspectives in Colorectal Cancer,Barcelona, Spain.
16.
Yan, X., Fong, Y.T., Jiang, H., Zhang, C., Hu, D., Shen, H., et al. (2002b, April). XY-S exhibits potent and selective cytotoxicity to a variety of cancer cells but not normal cells. Paper presented at the International Scientific Conference on Complementary, Alternative and Integrative Medicine Research, Boston, MA.
17.
Yan, X., Lin, H., Li, H., Traynor-Kaplan, A. E., Xia, Z., Lu, F., et al. (1999). Structure and property changes in certain materials influenced by the external qi of qigong. Materials Research Innovations, 2, 349-359.
18.
Yan, X., Lu, F., Jiang, H., Wu, X., Cao, W., Xia, Z., et al. (2002). Certain physical manifestation and effects of external qi of Yan Xin Life Science Technology. Journal of Scientific Exploration, 16(3), 381-411.
19.
Yan, X., Lu, Z., Zhang, T., Wang, H. & Zhu, R. (1988). The influence of external qi on the radioactive decay counting rate of 241 Am. Ziran Zazhi, 11, 809-812.
20.
Zauli, G., Milani, D., Mirandola, P., Mazzoni, M., Secchiero, P., Miscia, S., et al. (2001). HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway. FASEB Journal, 15(2), 483-491.
21.
Zhao, N., Zheng, C., Lu, Z., Li, S., & Yan, X. (1987). Observation on the effects of external qi on the structures and properties of certain materials. Acta Biophysica Sinica, 3, 93-94.
