The catecholamines dopamine (DA) and norepinephrine provide an essential modulatory influence on the working memory and attentional functions of the prefrontal cortex (PFC). The following critique reviews evidence that (1) either insufficient or excessive DA D1 receptor stimulation is detrimental to PFC function, while DA stimulation of the D2 family of receptors may contribute to detrimental actions in PFC and (2) that norepinephrine has an important beneficial influence on PFC function through its actions at post-synaptic, α 2A adrenergic receptors, but impairs PFC function through actions at α 1 adrenergic receptors. Critical levels of catecholamine stimulation may be needed to optimize PFC cognitive function; high levels of catecholamine release during stress may serve to take the PFC 'off-line' to allow faster, more habitual responses mediated by the posterior and/or subcortical structures to regulate behavior. These studies have relevance to our understanding and treatment of disorders with prominent symptoms of PFC dysfunction.
Aoki C., Go C-G., Venkatesan C., Kurose H. (1994) Perikaryal and synaptic localization of alpha-2A-adrenergic receptor-like immunoreactivity. Brain Res650: 181-204
2.
Arnsten Aft, Cai JX ( 1993) Post-synaptic alpha-2 receptor stimulation improves memory in aged monkeys: indirect effects of yohimbine versus direct effects of clonidine . Neurobiol Aging14: 597-603
3.
Arnsten Aft, Contant TA (1992) Alpha-2 adrenergic agonists decrease distractibility in aged monkeys performing the delayed response task. Psychopharmacology108: 159-169
4.
Arnsten A F T, Goldman-Rakic P G R (1984) Selective prefrontal cortical projections to the region of the locus coeruleus and raphe nuclei in the rhesus monkey. Brain Res306: 9-18
5.
Arnsten Aft, Goldman-Rakic PS (1985) Alpha-2 adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates. Science230: 1273-1276
6.
Arnsten Aft, Goldman-Rakic, PS (1986) Reversal of stress-induced delayed response deficits in rhesus monkeys by clonidine and naloxone. Soc Neurosci Abstr12: 1464
7.
Arnsten A F T, Goldman-Rakic PS (1990a) Stress impairs prefrontal cortex cognitive function in monkeys: Role of dopamine. Soc Neurosci Abstr16:164
8.
Arnsten Aft, Goldman-Rakic P.S. (1990b) Analysis of alpha-2 adrenergic agonist effects on the delayed nonmatch-to-sample performance of aged rhesus monkeys. Neurobiol Aging11: 583-590
9.
Arnsten A F T, Jentsch J.D. (1996) The alpha-1 adrenergic agonist, cirazoline, impairs spatial working memory performance in aged monkeys. Pharmac Biochem Behav in press
10.
Arnsten Aft, Leslie F.M. (1991) Behavioral and receptor binding analysis of the alpha-2 adrenergic agonist, UK-14304 (5 bromo-6 [2-imidazoline-2-yl amino] quinoxaline): Evidence for cognitive enhancement at an α2 adrenoceptor subtype. Neuropharmacology30: 1279-1289
11.
Arnsten Aft, Cai J.X., Goldman-Rakic P.S. (1988) The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: Evidence for alpha-2 receptor subtypes. J Neurosci8: 4287-4298
12.
Arnsten A F T, Cai J.X., Murphy B., Goldman-Rakic, P.S. (1994) Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys. Psychopharmacology116: 143-151
13.
Arnsten A F T, Cai J.X., Steere JC, Goldman-Rakic PS (1995) Dopamine D2 receptor mechanisms contribute to age-related cognitive decline: The effects of quinpirole on memory and motor performance in monkeys. J Neurosci15: 3429-3439
14.
Arnsten Aft, Steere JC, Hunt RD ( 1996) The contribution of alpha-2 noradrenergic mechanisms to prefrontal cortical cognitive function: Potential significance to attention deficit hyperactivity disorder. Arch Gen Psychiat53: 448-455
15.
Baddeley AD (1972) Selective attention and performance in dangerous environments. Br J Psychol63: 537-546
16.
Barkley RA, Grodzinsky G., DuPaul GJ (1992) Frontal lobe functions in attention deficit disorder with and without hyperactivity: a review and research report. J Abnorm Child Psychol20:163-188
17.
Bartus RT (1979) Effects of aging on visual memory, sensory processing and discrimination learning in a nonhuman primate. In Ordy JM, Brizzee K (eds), Sensory systems and communication in the elderly. Raven Press, New York, pp. 85-114
18.
Bebbington P., Wilkins S., Jones P., Foerster A., Murray R., Toone B., Shon L. ( 1993) Life events and psychosis. Initial results from the Camberwell collaborative psychosis study. Br J Psychol162 : 72-79
19.
Benson D.F. (1991) The role of frontal dysfunction in attention deficit hyperactivity disorder. J Child Neurol6: S9-S12
20.
Bergson C., Mrzljak L., Smiley J.F., Goldman-Rakic P.S., Levenson R. (1994) Differential distribution of D1 and D5 dopamine receptors in spines and shafts ofprojection neurons. Soc Neurosci Abstr20: 643
21.
Berridge CW, Foote S.L. (1991) Effects of locus coeruleus activation on electroencephalographic activity in neocortex and hippocampus. J Neurosci11: 3135-3145
22.
Birnbaum S., Arnsten Aft (1996) The alpha-2A noradrenergic agonist, guanfacine, reverses the working memory deficits induced by pharmacological stress (FG7142) . Soc Neurosci Abstr22: 1126
23.
Bourdelais AJ, Deutch AY (1994) The effects of haloperidol and clozapine on extracellular GABA levels in the prefrontal cortex of the rat: An in vivo microdialysis study. Cerebral Cortex4: 69-77
24.
Bourgeois J-P., Goldman-Rakic, P.S., Rakic P. (1994) Synaptogenesis in the prefrontal cortex of rhesus monkeys. Cerebral Cortex4: 78-96
25.
Boyajian C.L., Leslie F.M. (1987) Pharmacological evidence for alpha-2 adrenoceptor heterogeneity: differential binding properties of [3H]rauwolscine and [3H]idazoxan in rat brain. J Pharmac Exp Ther241: 1092-1098
26.
Boyajian C.L., Loughlin S.E., Leslie F.M. (1987) Anatomical evidence for alpha-2 adrenoceptor heterogeneity: differential autoradiographic distributions of [3H]rauwolscine and [3H]idazoxan in rat brain. J Pharmac Exp Ther241: 1079-1091
27.
Breier A., Wolkowitz OM, Pickar D. (1991) Stress and schizophrenia. In Tamminga C A, Schult S C (eds), Advances in neuropsychiatry and psychopharmacolog , Vol. 1, Schizophrenia research . Raven Press, New York
28.
Broadbent D.E. (1971) Decision and stress. Academic Press, London
29.
Broersen L.M., Heinsbroek R P W, de Bruin J P C, Uylings H B M, Olivier B. (1995) The role of the medial prefrontal cortex of rats in short-term memory functioning: further support for involvement of cholinergic, rather than dopaminergic mechanisms. Brain Res674: 221-229
30.
Brozoski T., Brown R.M., Rosvold H.E., Goldman P.S. (1979) Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. Science205: 929-931
31.
Bubser M., Schmidt WJ (1990) 6-OHDA lesions of the rat prefrontal cortex increases locomotor activity, impairs acquisition of delayed alternation tasks, but does not affect uninterrupted tasks in the radial maze. Behav Brain Res37:157-168
32.
Buzsaki G., Kennedy B., Solt V.B., Ziegler M. (1991) Noradrenergic control of thalamic oscillation: the role of alpha-2 receptors. Eur J Pharmac3: 222-229
Cahill L. (1997) Interactions between catecholamines and the amygdala in emotional memory: sub-clinical and clinical evidence. Proceedings of the Eighth International Catecholamine Symposium, Catecholamines: bridging basic science with clinical medicine. Adv Pharmac , in press
35.
Cai J.X., Ma Y., Xu L., Hu X. (1993) Reserpine impairs spatial working memory performance in monkeys: reversal by the α-2-adrenergic agonist clonidine. Brain Res614:191-196
36.
Carli M., Robbins T.W., Evenden J.L., Everitt B.J. (1983) Effect of lesions to ascending noradrenergic neurons on performance of a 5-choice serial reaction task in rats: implications for theories of dorsal noradrenergic bundle function based on selective attention and arousal. Behav Brain Res9: 361-380
37.
Carlson S., Tanila H., Rama P., Mecke E., Pertovaara A. (1992) Effects of medetomidine, an α-2 adrenoceptor agonist, and atipamezole, and α-2 antagonist, on spatial memory performance in adult and aged rats. Behav Neural Biol58: 113-119
38.
Chappell P.B., Riddle M.A., Scahill L., Lynch K., Schultz R., Arnsten A F T, Leckman J.F., Cohen D.L. (1995) Guanfacine treatment of comorbid attention deficit hyperactivity disorder and Tourette's syndrome: preliminary clinical experience . J Am Acad Child Adol Psychiat34: 1140-1146
39.
Chelune G.J., Ferguson W., Koon R., Dickey TO (1986) Frontal lobe disinhibition in attention deficit disorder. Child Psychol Hum Devel16: 221-234
40.
Cook E.H., Stein M.A., Krasowski M.D., Cox N.J., Olkon D.M., KiefferJ.E., Leventhal B.L. (1995) Association of attention-deficit disorder and the dopamine transporter gene. Am J Hum Genet56: 993-998
41.
Coull JT (1994) Pharmacological manipulations of the α-2 noradrenergic system: Effects on cognition. Drugs and Aging5: 116-126
42.
Coull JT, Middleton HC, Robbins T.W., Sahakian BJ (1995) Contrasting effects of clonidine and diazepam on tests of working memory and planning. Psychopharmacology120: 311-321
43.
Daniel D.G., Weinberger D.R., Jones D.W., Zigun J.R., Cippola R., Handel S., Bigelow L.B., GoldbergT.E., Berman K.F., KleinmanJ.E. (1991) The effect of amphetamine on regional cerebral blood flow during cognitive activation in schizophrenia. J Neurosci11:1907-1917
44.
Davies B.T., Wellman PJ (1992) Effects on ingestive behavior in rats of the alpha-1-adrenoceptor agonist cirazoline. Eur J Pharmac210: 11-16
45.
Davis KL, Kahn RS, Ko G., Davidson M. (1991) Dopamine in schizophrenia: A review and reconceptualization . Am J Psychiat148: 1474-1486
46.
Deutch AY, Roth R.H. (1990) The determinants of stress-induced activation of the prefrontal cortical dopamine system. Prog Brain Res85: 367-403
47.
Dohrenwend B.P., Shrout P.E., Link B.G., Skodol A.E., Stueve A. (1995) Life events and other possible psychosocial risk factors for episodes of schizophrenia and major depression: A case-control study. In Mazure C M (ed.), Does stress cause psychiatric illness? Progress in psychiatry, Vol. 46. American Psychiatric Press, Washington, pp. 43-65
48.
Dolan R.J., Fletcher P., Frith C.D., Friston K.J., Frackowiak R S J, Grasby PM (1995) Dopaminergic modulation of impaired cognitive activation in the anterior cingulate in schizophrenia. Nature378: 180-182
49.
Ennis M., Shipley M.T., Aston-Jones G., Williams J.T. (1997) Afferent control of nucleus locus coeruleus: Differential regulation by "shell" and "core" inputs. Proceedings of the Eighth International Catecholamine Symposium, Catecholamines: bridging basic science with clinical medicine. Adv Pharmac, in press
50.
Famularo R., Kinscherff R., Fenton T. (1992) Psychiatric diagnoses of maltreated children: Preliminary findings. J Am Acad Child Adolesc Psychiat31: 863-867
51.
Feldman M.L., Dowd C. ( 1975) Loss of dendritic spines in aged cerebral cortex. Anat Embryol148: 279-301
52.
Fields R.B., Van Kammen D.P., Peters J.L., Rosen J., Van Kammen W.B., Nugent A., Stipetic S., Linnoila M. (1988) Clonidine improves memory function in schizophrenia independently from change in pyschosis. Schizophr Res1: 417-423
53.
Garey L.J., Ong W.Y., Patel T.S., Kanani M., Davis A., Hornstein C., Bauer M. (1995) Reduction in spine number on cortical pyramidal neurons in schizophrenia. Soc Neurosci Abstr21: 237
54.
Gaspar P., Berger B., Febvret A., Vigny A., Henry J.P. (1989) Catecholamine innervation of the human cerebral cortex as revealed by comparative immunohistochemistry of tyrosine hydroxylase and dopamine-beta-hydroxylase. J Comp Neurol279: 249-271
55.
Gaspar P., Duyckaerts C., Alvarez C., Javoy-Agid F., Berger B. (1991) Alterations of dopaminergic and noradrenergic innervations in motor cortex in Parkinson's disease. Ann Neurol30: 365--374
56.
German D.C., Walker B.S., Manaye K., Smith W.K., Woodward D.J., North AJ (1988) The human locus coeruleus: Computer reconstruction of the cellular distribution. J Neurosci8:1776-1788
57.
Glantz LA, Lewis DA (1995) Assessment of spine density on layer III pyramidal cells in the prefrontal cortex of schizophrenic subjects. Soc Neurosci Abstr21: 239
58.
Goldman-Rakic PS, Brown, RM (1981) Regional changes of monoamines in cerebral cortex and subcortical structures of aging rhesus monkeys. Neuroscience6:177-187
59.
Goldstein L.E., Rasmussen A.M., Bunney B.S., Roth R.H. (1995) Role of the amygdala in the coordination of behavioral, neuroendocrine, and prefrontal cortical monoamine responses to conditioned stress in the rat. J Neurosci16: 4787-4798
60.
Grace A.A. (1993) Cortical regulation of subcortical dopamine systems and its possible relevance to schizophrenia. J Neural Transm91: 111-134
61.
Grenhoff J., Svensson T.H. (1989) Clonidine modulates dopamine cell firing in rat ventral tegmental area. Eur J Pharmac165: 11-18
62.
Hadfield M.G., Milio C. (1990) Regional brain monoamine levels and utilization in middle-aged rats. Life Sci46: 295-299
63.
Hartley L.R., Adams R.G. (1974) Effect of noise on the Stroop test. J Exp Psychol102 : 62-66
64.
Hochanadel G., Kaplan E. (1984) Neuropsychology of normal aging. In Albert M L (ed.), Clinical neurology of aging . New York, Oxford University Press , pp. 231-244
65.
Hockey G R J (1970) Signal probability and spatial location as possible bases for increased selectivity in noise. Q J Exp Psychol22: 37-42
66.
Horrigan J.P., Barnhill L.J. (1995) Guanfacine for treatment of attention-deficit hyperactivity disorder in boys. J Child Adolesc Psychopharm5: 215-223
67.
Hunt R.D., Minderaa R.B., Cohen D.J. (1985) Clonidine benefits children with attention deficit disorder and hyperactivity: report of a double-blind placebo-crossover therapeutic trial. J Am Acad Adolesc Child Psychiat24: 617-629
68.
Hunt RD, Arnsten, Aft, Asbell, MD (1995) An open trial of guanfacine in the treatment of attention deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiat34: 50-54
69.
Iversen L.L., Rossor M.N., Reynolds G.P. et al. (1983) Loss of pigmented dopamine beta hydroxylase positive cells from locus coeruleus in senile dementia of Alzheimer's type . Neurosci Letts39: 95-100
70.
Jackson WJ, Buccafusco JJ (1991) Clonidine enhances delayed matching-to-sample performance by young and aged monkeys. Pharmac Biochem Behav39: 79-84
71.
Kobilka BK, Matsui H., Kobilka T.S. et al. (1987) Cloning, sequencing, and expression of the gene encoding for the human platelet α-2-adrenergic receptor. Science238: 650-656
72.
Leslie F.M., Loughlin S.E., Sternberg D.B., McGaugh J.L., Young L.E., Zornetzer S.F. (1985) Noradrenergic changes in senescent memory loss . Brain Res359: 292-299
73.
Levin S. (1984) Frontal lobe dysfunction in schizophrenia. II. Impairments of psychological and brain functions. J Psychiat Res18: 27-55
74.
Li B-M., Mei Z-T. (1994) Delayed response deficit induced by local injection of the α2 adrenergic antagonist yohimbine into the dorsolateral prefrontal cortex in young adult monkeys. Behav Neural Biol62:134-139
75.
Li B-M., Hu X-T., Mei Z-T. (1994) Prefrontal injection of the alpha-2 adrenergic antagonist yohimbine impairs performance of a delayed go/no-go task in monkeys . Acta Physiol Sin46: 249-257
76.
Li B-M., Mei Z-T. (1995) Alpha-2 adrenergic modulation of prefrontal neuronal activity related to working memory in monkeys. Abstracts of the 3rd Congress of Federation of Asian and Oceanian Physiological Societies: 96
77.
Loge D.V., Staton R.D., Beatty W.W. (1989) Performance of children with ADHD on tests sensitive to frontal lobe dysfunction. J Am Acad Child Adolesc Psychiat29: 540-545
78.
Lomasney J.W., Lorenz W., Allen L.F. et al. (1990) Expansion of the alpha-2 adrenergic family: Cloning and characterization of a human alpha-2-adrenergic receptor subtype, the gene for which is located on chromosome 2. Proc Nat Acad Sci USA87: 5094-5098
79.
Luine V., Bowling D., Hearns M. (1990) Spatial memory deficits in aged rats: contributions of monoaminergic systems. Brain Res537: 271-278
80.
Mair RG, McEntee WJ (1986) Cognitive enhancement in Korsakoff's psychosis by clonidine: A comparison with 1-dopa and ephedrine. Psychopharmacology88: 374-380
81.
Marjamaki A., Luomala K., Ala-Uotila S., Scheinin M. (1993) Use of recombinant human α-2-adrenoceptors to characterize subtype selectivity of antagonist binding. Eur J Pharmac246: 219-226
82.
Mattes JA (1980) The role of frontal lobe dysfunction in childhood hyperkinesis. Comp Psychiat21: 358-369
83.
Matthysse S. (1973) Antipsychotic drug actions: a clue to the neuropathology of schizophrenia? Fed Proc32: 200-205
84.
McEntee WJ, Mair RG ( 1990) The Korsakoff syndrome: a neurochemical perspective. Trends Neurosci13: 340-344
85.
Merry SN, Andrews LK (1994) Psychiatric status of sexually abused children 12 months after disclosure of abuse. J Am Acad Child Adolesc Psychiat33: 939-944
86.
Mervis RF, Pope D., Lewis R., Dvorak RM, Williams LR (1991) Exogenous nerve growth factor reverses age-related structural changes in neocortical neurons in the aging rat. Ann NY Acad Sci640: 95-101
87.
Moffoot A., O'Carroll R.E., Murray C., Dougall N., Ebmeier K., Goodwin G.M. (1994) Clonidine infusion increases uptake of Tcexametazamine in anterior cingulate cortex in Korsakoff's psychosis. Psychol Med24: 53-61
88.
Mrzljak L., Bergson C., Pappy M., Levenson R., Huff R., Goldman-Rakic PS (1996) Localization of dopamine D4 receptors in GABAergic neurons of the primate brain. Nature381: 245-248
89.
Murphy BL, Roth RH, Arnsten Aft (1994) The effects of FG7142 on prefrontal cortical dopamine and spatial working memory in rat and monkey. Soc Neurosci Abstr20:1019
90.
Murphy B.L., Arnsten A F T, Goldman-Rakic, P.S., Roth R.H. (1996a) Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys. Proc Nat Acad Sci USA93:1325-1329
91.
Murphy BL, Arnsten A F T, Jentsch J.D., Roth R.H. (1996b) Dopamine and spatial working memory in rats and monkeys: Pharmacological reversal of stress-induced impairment. J Neurosci16: 7768-7775
92.
Murphy B., Roth R., Arnsten A F T (1996c) Clozapine reverses the spatial working memory deficits induced by FG7142 in monkeys. Neuropsychopharmacology , in press
93.
Nicholas A.P., Pieribone V., Hokfelt T. (1993) Distributions of mRNAs for α-2-adrenergic receptor subtypes in rat brain: an in situ hybridization study. J Comp Neurol328: 575-594
94.
Penit-Soria J., Audinat E., Crepel F. (1987) Excitation of rat prefrontal cortical neurons by dopamine: an in vitro electrophysiological study. Brain Res425: 263-274
95.
Pirot S., Glowinski J., Thierry AM (1996) Mediodorsal thalamic evoked responses in the rat prefrontal cortex: influence of the mesocortical DA system. NeuroReport7:1437-1441
96.
Rajkowski J., Kubiak P., Ivanova S., Aston-Jones G. (1997) State-related activity and reactivity of locus coeruleus neurons in behaving monkeys. Proceedings of the Eighth International Catecholamine Symposium, Catecholamines: bridging basic science with clinical medicine. Adv Pharmac, in press
97.
Rapp P.R., Amaral D.G. (1989) Evidence for task-dependent memory dysfunction in the aged monkey. J Neurosci9: 3568-3576
98.
Regan J.W., Kobilka T.S., Yang-Feng T.L., Caron M.G., Lefkowitz R.J., Kobilka B.K. (1988) Cloning and expression of a human kidney cDNA for an α-2 adrenergic receptor subtype. Proc Nat Acad Sci USA85: 6301-6305
99.
Reis D.J., Granata A.R., Joh T.H., Ross C.A., Ruggiero D.A., Park D.H. (1984) Brain stem catecholamine mechanisms in tonic and reflex control of blood pressure. Hypertension SII6(5): 7-15
100.
Retaux S., Besson MJ, Penit-Soria J. (1991) Opposing effects of dopamine D2 receptor stimulation on the spontaneous and electrically evoked release of 3[H]GABA on rat PFC slices. Neuroscience42: 61-71
101.
Roberts A.C., De Salvia M.A., Wilkinson L.S., Collins P., Muir J.L., Everitt B.J., Robbins T.W. (1994) 6-Hydroxydopamine lesions of the prefrontal cortex in monkeys enhance performance on an analog of the Wisconsin Card Sort Test: possible interactions with subcortical dopamine. J Neurosci14: 2531-2544
102.
Roberts D C S, Price M T C, Fibiger H.C. (1976) The dorsal tegmental noradrenergic projection: an analysis of its role in maze learning. J Comp Physiol Psychol90: 363-372
103.
Rosenberg DR, Lewis DA (1994) Changes in the dopaminergic innervation of monkey prefrontal cortex during late postnatal development: a tyrosine hydroxylase immunohistochemical study. Biol Psychiat36: 272-277
104.
Roth R.H., Tam S-Y., Ida Y., Yang J-X., Deutch AY (1988) Stress and the mesocorticolimbic dopamine systems . Ann NY Acad Sci537: 138-147
105.
Sara S.J., Herve-Minvielle A. (1995) Inhibitory influence of frontal cortex on locus coeruleus. Proc Nat Acad Sci USA92: 6032-6036
106.
Sawaguchi T., Goldman-Rakic PS (1991) D1 dopamine receptors in prefrontal cortex: Involvement in working memory. Science251: 947-950
107.
Sawaguchi T., Matsumura M., Kubota K. (1990) Catecholaminergic effects on neuronal activity related to a delayed response task in monkey prefrontal cortex. J Neurophys63: 1385-1400
108.
Scheinin M., Lomasney J.W., Hayden-Hixson DM, Schambra U.B., Caron M.G., Lefkowitz R.J., Fremeau R.T. (1994) Distribution of α-2-adrenergic receptor subtype gene expression in rat brain. Mol Brain Res21:133-149
109.
Schneider J.S., Kovelowski C.J. (1990) Chronic exposure to low doses of MPTP. I Cognitive deficits in motor asymptomatic monkeys. Brain Res519: 122-128
110.
Seamans JK, Floresco SB, Phillips AG (1995) Selective impairment on a delayed radial arm task following local administration of a D1, but not a D2, antagonist into the prefrontal cortex. Soc Neurosci Abstr21: 1942
111.
Sesack SR, Bunney BS (1989) Pharmacological characterization of the receptor mediating electrophysiological responses to dopamine in the rat medial prefrontal cortex: a microiontophoretic study. J Pharmac Exp Ther248:1323-1333
112.
Siddiqi Z.A., KemperT.L., Rosene D.L., Feldman M. (1995) Age related changes in the rhesus monkey: Neuronal loss in substantia nigra-pars compacta and ventral tegmental area. Soc Neurosci Abstr21:1565
113.
Simon H. (1981) Dopaminergic A10 neurons and the frontal system . J Physiol77: 81-95
114.
Sirvio J., Riekkinen P., Vajanto I., Koivisto E., Riekkinen PJ (1991) The effects of guanfacine, α-2 agonist, on the performance of young and aged rats in spatial navigation task. Behav Neural Biol56:101-107
115.
Sladek J.R., Sladek C.D. (1979) Relative quantification of monoamine histofluorescence in young and old nonhuman primates. In Finch CE, Potter DE, Kenny AD (eds), Parkinson's disease II. Plenum Press, New York, pp. 231-239
116.
Smiley J.F., Goldman-Rakic P.S. (1993) Heterogeneous targets of dopamine synapses in monkey prefrontal cortex demonstrated by serial section electron microscopy. Cerebral Cortex3: 223-238
117.
Smiley J.F., Levey A.I., Ciliax B.J., Goldman-Rakic P.S. (1994) D1 dopamine receptor immunoreactivity in human and monkey cerebral cortex: predominant localization in dendritic spines. Proc Nat Acad Sci USA91: 5720-5724
118.
Snyder S.H., Bannerjee S., Yamamura H., Greenberg D. (1974) Drugs, neurotransmitters and schizophrenia: phenothiazines, amphetamine and enzymes synthesizing psychotomimetic drugs and schizophrenia research. Science184: 1243-1253
119.
Sokolowski J.D., Salamone J.D. (1994) Effects of dopamine depletions in the medial prefrontal cortex on DRL performance and motor activity in the rat. Brain Res642: 20-28
120.
Sokolowski J.D., Cousins M.S., Nelson J., Salamone J.D. (1995) A neurochemical and behavioral investigation of the effects of prefrontal cortical dopamine antagonism in the rat.
121.
Steere J.C., Arnsten A F T (1994) The alpha-2A agonist, guanfacine, improves delayed response performance and calms behavior in young monkeys: relevance to attention deficit disorder. Soc Neurosci Abstr20: 831
122.
Steere J.C., Li B-M., Jentsch J.D., Mathew R., Taylor J.R., Arnsten A F T (1996) Alpha-1 noradrenergic stimulation impairs, while α 2 stimulation improves, prefrontal cortex spatial working memory function . Soc Neurosci Abstr22: 1126
123.
Svensson T.H., Bunney B.S., Aghajanian G.K. (1975) Inhibition of both noradrenergic and serotonergic neurons in brain by the alpha-adrenergic agonist clonidine. Brain Res92: 291-306
124.
Tanila H., Rama P., Carlson S. (1996). The effects of prefrontal intracortical microinjections of an α-2 agonist, α-2 antagonist and lidocaine on the delayed alternation performance of aged rats. Brain Res Bull40: 117-119
125.
Thierry A.M. (1997) Dopamine function in the prefrontal cortex. Proceedings of the Eighth International Catecholamine Symposium, Catecholamines: bridging basic science with clinical medicine. Adv Pharmac, in press
126.
Thierry AM, Tassin JP, Blanc G., Glowinski J. (1976) Selective activation of the mesocortical DA system by stress. Nature263: 242-244
127.
Thierry A.M., Le Douarin C., Penit J., Ferron A., Glowinski J. (1986) Variation in the ability of neuroleptics to block the inhibitory influence of dopaminergic neurons on the activity of cells in the rat prefrontal cortex. Brain Res Bull16: 155-160
128.
Uhlen S., Wikberg J E S (1991) Delineation of rat kidney α-2A and α-2B-adrenoceptors with [3H]RX821002 radioligand binding: Computer modeling reveals that guanfacine is an α-2A-selective compound. Eur J Pharmac202: 235-243
129.
Verma A., Moghaddam B. (1996) NMDA receptor antagonists impair prefrontal cortex function as assessed by spatial delayed alternation performance in rats: modulation by dopamine. J Neurosci16: 373-379
130.
Vijayashankar N., Brody H. (1979) A quantitative study of the pigmented neurons in the nuclei locus coeruleus and subcoeruleus in man as related to aging. J Neuropath Exp Neurol38: 490-497
131.
Weinberger D.R., Berman K.F., Zec R.F. (1986) Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. Arch Gen Psychiat43:114-124
132.
Wenk G.L., Pierce D.J., Struble R.G., Price D.L., Cork L.C. (1989) Age-related changes in multiple neurotransmitter systems in the monkey brain. Neurobiol Aging10: 11-19
133.
West RL ( 1996) An application of prefrontal cortex function theory to cognitive aging. Psychol Bull120: 272-292
134.
Williams G.V., Goldman-Rakic P.S. (1995) Modulation of memory fields by dopamine D1 receptors in prefrontal cortex. Nature376: 572-575
135.
Yang C.R., Seamans J.K. (1996) Dopamine D1 receptor actions in layer V-VI rat prefrontal cortex neurons in vitro: Modulation of dendritic-somatic signal integration. J Neurosci16: 1922-1935
136.
Yang CR, Seamans J.K., Gorelova N. (1996) Focal dendritic D1 receptor stimulation differentially modulates layers I-II and V-VI glutamate inputs to deep layer prefrontal cortical pyramidal neurons in vitro. Soc Neurosci Abstr22: 1770
137.
Zahrt J., Taylor J.R., Arnsten A F T (1996) Supranormal stimulation of dopamine D1 receptors in the prefrontal cortex impairs spatial working memory in rats. Soc Neurosci Abstr22:1128
