Regional differences in the effect of haloperidol and atypical neuroleptics on interstitial levels of DOPAC in the rat forebrain: an in vivo microdialysis study
Restricted accessResearch articleFirst published online March, 1996
Regional differences in the effect of haloperidol and atypical neuroleptics on interstitial levels of DOPAC in the rat forebrain: an in vivo microdialysis study
The effect of 'typical' and 'atypical' neuroleptics on interstitial levels of the dopamine metabolite 3,4- dihydroxyphenylacetic acid ([DOPAC]e) in the dorsolateral striatum (DLSt), the nucleus accumbens (NAc) and the medial prefrontal cortex (PFC) was investigated in awake rats by use of the microdialysis technique. All neuroleptics increased [DOPAC]e in the DLSt, NAc and in PFC. However, the 'atypical' neuroleptics clozapine, risperidone, sertindole and NNC 22-0031 showed an apparent cortical selectivity by preferentially elevating [DOPAC]e in the PFC compared with the DLSt and NAc, a feature which was not observed with the 'typical' neuroleptic haloperidol. Our data suggest that 'atypical' neuroleptics can be differentiated from the 'typical' neuroleptic, haloperidol, with respect to their ability to increase [DOPAC]e in PFC relative to DLSt and NAc.
Andén N.E., Grabowska-Andén M., Liljenberg B. (1983) On the presence of autoreceptors on dopamine neurons in different brain regions. J Neural Transm57: 129-137
Bannon M.J., Reinhard Jr J.F., Bunney E.B., Roth R.H. (1982) Unique response to antipsychotic drugs is due to absence of terminal autoreceptors in mesocortical dopamine neurons. Nature296: 444-446
4.
Benveniste H., Huttemeier P.C. (1990) Microdialysis—theory and application. Progr Neurobiol35:195-215
5.
Borison R.L., Diamond B.I., Pathiraja A., Meibach R.C. (1992) Clinical overview of risperidone. In Meltzer H Y (ed.), Novel antipsychotic drugs . Raven Press, New York, pp. 233-239
6.
Carlsson A., Lindquist M. (1963) Effects of chlorpromazine or haloperidol on formation of 3-methoxytyramine and normetanephrine in mouse brain. Acta Pharmacol Toxicol20:140-144
7.
Chen J., Paredes W., van Praag H.M., Gardner E.L. (1992) Serotonin denervation enhances responsiveness of presynaptic dopamine efflux to acute clozapine in nucleus accumbens but not in caudate-putamen. Brain Res582:173-179
8.
Chiodo L.A., Bunney B.S. (1985) Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons. J Neurosci5: 2539-2544
9.
Chiodo L.A., Bannon M.J., Grace A.A., Roth R.H., Bunney B.S. (1984) Evidence for the absence of impulse-regulating somatodendritic and synthesis-modulating nerve terminal autoreceptors on subpopulations of mesocortical dopamine neurons. Neuroscience12: 1-16
10.
Creese I., Burt D.R., Snyder S.H. (1976) Dopamine receptor binding predicts clinical and pharmacological potencies of anti-schizophrenic drugs. Science192: 481-483
11.
Drew K.L., O'ConnorW.T., KehrJ., Ungerstedt U. (1990) Regional specific effects of clozapine and haloperidol on GABA and dopamine release in rat basal ganglia. Eur J Pharmacol187: 385-397
12.
Essig E.C., Kilpatrick I.C. (1991) Influence of acute and chronic haloperidol treatment on dopamine metabolism in the rat caudateputamen, prefrontal cortex and amygdala . Psychopharmacology104: 194-200
13.
Fink-Jensen A., Kristensen P. (1994) Effects of typical and atypical neuroleptics on Fos protein expression in the rat forebrain. Neurosci Lett182:115-118
14.
Galloway M.P., Wolf M.E., Roth R.H. (1986) Regulation of dopamine synthesis in the medial prefrontal cortex is mediated by release modulating autoreceptors: studies in vivo. J Pharmacol Exp Ther236:689-698
15.
Hernandez L., Hoebel B.G. (1989) Haloperidol given chronically decreases basal dopamine in the prefrontal cortex more than the striatum or nucleus accumbens as simultaneously measured by microdialysis. Brain Res Bull22: 763-769
16.
Hyttel J., Nielsen J.B., Nowak G. (1992) The acute effect of sertindole on brain 5-HT 2, D2 and d1 receptors (ex vivo radiocepter binding studies). J Neural Transm89: 61-69
17.
Imperato A., Di Chiara G. (1985) Dopamine release and metabolism in awake rats after systematic neuroleptics as studied by trans-striatal dialysis. J Neurosci5: 297-306
18.
Invernizzi R., Morali F., Pozzi L., Samanin R. (1990) Effects of acute and chronic clozapine on dopamine release and metabolism in the striatum and nucleus accumbens of conscious rats. Br J Pharmacol100: 774-778
19.
Kane J., Honigfeld G., Singer J., Meltzer H., The Clozaril Collaborative Study Group (1988) Clozapine for the treatment-resistant schizophrenic. Arch Gen Psychiatr45: 789-796
20.
Karoum F., Egan M.F. (1992) Dopamine release and metabolism in the rat frontal cortex nucleus accumbens, and striatum: a comparison of acute clozapine and haloperidol. Eur J Pharmacol105: 703-707
21.
Leysen J.E., Janssen P M F, Gommeren W., Wynants J., Pauwels P.J., Janssen P A J (1992) In vitro and in vivo receptor binding and effects on monoamine turnover in rat brain regions of the novel antipsychotics risperidone and ocaperidone. Mol Pharmacol41: 494-508
22.
Leysen J.E., Janssen P M F, Schotte A., Luyten W H M L, Megens A A H P (1993) Interaction of antipsychotic drugs with neurotransmitter receptor sites in vitro and in vivo in relation to pharmacological and clinical effects: role of 5HT2 receptors. Psychopharmacology112: S40-S54
Martin P.T., Grebb J.A., Schmitz P., Sebree T., Kashkin K. (1994) Efficacy and safety of sertindole in double-blind, placebo-controlled trials of schizophrenic patients. Schizophrenia Res11(2): 107 (abstract)
25.
Meltzer H.Y. (1991) The mechanism of action of novel antipsychotic drugs. Schizophrenia Bull17: 263-287
26.
Meltzer H.Y. (1992) The mechanism of action of clozapine in relation to its clinical advantages. In Meltzer H Y (ed.), Novel antipsychotic drugs. Raven Press, New York, pp.1-13
27.
Moghaddam B., Bunney B.S. (1990) Acute effects of typical and atypical antipsychotic drugs on the release of dopamine from prefrontal cortex, nucleus accumbens, and striatum of the rat: an in vivo microdialysis study. J Neurochem54:1755-1760
28.
Morgan J., Curran T. (1989) Stimulus-transcription coupling in neurons : role of cellular immediate-early genes. Trends Neurosci12: 459-462
29.
Seeman P., Lee T., Chau-Wong M., Wong K. ( 1976) Antipsychotic drug doses and neuroleptic/dopamine receptors . Nature261: 717-719Skarsfeldt T. (1992) Electrophysiological profile of the new atypical neuroleptic, sertindole, on midbrain dopamine neurones in rats: acute and repeated treatment. Synapse10: 25-33
30.
Sánchez C., Arnt J., Dragsted N., Hyttel J., Lembol H.L., Meier E., Perregaard J., Skarsfeldt T. (1991) Neurochemical and in vivo pharmacological profile of sertindole, a limbic-selective neuroleptic compound. Drug Devel Res22: 239-250
31.
Talmaciu R.K., Hoffmann I.S., Cubeddu L.X. (1986) Dopamine autoreceptors modulate dopamine release from the prefrontal cortex. J Neurochem47: 865-870
32.
Waldemeier P.C., Maitre L. (1976) On the relevance of preferential increases of mesolimbic versus striatal dopamine turnover for the prediction of antipsychotic activity of psychotropic drugs. J Neurochem27: 589-597
33.
Weinberger D.R. (1988) Schizophrenia and the frontal lobe. Trends Neurosci11: 367-370
34.
Westerink B H C, Korf J. ( 1976) Acidic dopamine metabolites in cortical areas of the rat brain: localization and effects of drugs. Brain Res113: 429-434
35.
Zetterström T., Sharp T., Ungerstedt U. (1985) Effect of neuroleptic drugs on striatal dopamine release and metabolism in the awake rat studied by intracerebral dialysis . Eur J Pharmacol106: 27-37
