Nineteen patients resistant to paroxetine monotherapy were treated by lithium augmentation for 6 weeks to assess tolerability. Although the addition of lithium increased the number of adverse events, none were serious. The combination of lithium and paroxetine is safe enough to warrant further investigation as a treatment for resistant depression.
Apseloff G., Wilner K., von Deutsch D., Henry E., Tremaine L., Gerber N., Lazar J. (1992) Sertraline does not alter steady state concentrations or renal clearance of lithium in healthy volunteers. J Clin Pharmacol32: 643-646
2.
Committee on Safety of Medicines (1989) Current problems. Fluvoxamine and fluoxetine—interaction with monoamine oxidase inhibitors, lithium and tryptophan. May
3.
Delgado P., Price L., Charney D., Heninger G. (1988) Efficacy of fluvoxamine in treatment of refractory depression. J Affective Disord15: 55-60
4.
Dinan T.G. (1993) Lithium augmentation in sertraline-resistant depression: a preliminary dose-response study. Acta Psychiatr Scand88: 300-301
5.
Haenen J. (1991) An interaction study of paroxetine on lithium plasma levels in depressed patients stabilised on lithium therapy. Abstract. 5th World Congress of Biological Psychiatry. Florence, June
6.
Hawley C.J., Roberts A.G., Baldwin D.S. (1994) Tolerability of combined treatment with lithium and fluoxetine: 14 cases treated under open conditions. Int Clin Psychopharmacol9: 31-33
7.
Hendrickx B., Floris M. (1991) A controlled pilot study of the combination of fluvoxamine and lithium. Curr Ther Res49: 106-110
8.
Katona C., Robertson M., Abou-Saleh M., Nairac B., Edwards D., Lock T., Burns R., Harrison D., Taylor N. (1993) A placebo controlled trial of lithium augmentation of fluoxetine and lofepramine. Int Clin Psychopharmacol8: 323
9.
Stein G., Bernadt M. (1993) Lithium augmentation therapy in tricyclic resistant depression. A controlled study using lithium in low and normal doses. Br J Psychiatr162: 634-640
10.
Sternbach H. (1991) The serotonin syndrome. Am J Psychiatr148: 705-713
