Effective treatment with pimozide of a male patient with secondary de Clérambault's syndrome (DCS) and schizophrenia is reported. There was no evidence of relapse at 24-month follow-up. Pimozide is suggested to be the drug of choice in DCS and may be in other disorders in which symptoms of erotomania are prominent. The unique anti-erotomanic activity of pimozide may be due to its calcium channel antagonist activity, a property which is not shared by the other antipsychotic drugs.
American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders (3rd edn, revised) (DSM-III-R), American Psychiatric Association , Washington , DC
2.
De Clérambault (1942) Les psychoses passionelles. In Oevre psychiatrique. Presses Universitaires de France, Paris
3.
Ellis P., Mellsop G. (1985) De Clérambault's syndrome—a nosological entity?Br J Psychiatr146: 90-93
Peroutka S.J., Snyder S.H. (1980) Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic and histamine receptors to clinical potency. Am J Psychiatr137: 1518-1522
6.
Segal J.H. (1989) Erotomania revisited: From Kraepelin to DSM-III-R . Am J Psychiatr146: 1261-1266
7.
Wagner J.A., Guggino S.E., Reynolds I.J., Snowman A.M., Biswas A., Olivera B.M., Snyder S.H. (1988) Calcium antagonist receptors. Ann NY Acad Sci522: 116-133
