Positron-emitting radioligands for studies in vivo-probes for human psychopharmacology

Ariens E.J. (1986) Chirality in bioactive agents and its pitfalls . Trends Pharmacol Sci 7: 200-205

Arnett C.D. , Fowler J.S. , Wolf A.P. , Shiue C.Y. , McPherson D.W. (1985) [18F]-N-methylspiperone: the radioligand of choice for PETT studies of the dopamine receptor in human brain. Life Sci 36: 1359-1366

Arnett C.D. , Fowler J.S. , MacGregor R R. , Schlyer D.G. , Wolf A.P. , Langström B. , Halldin C. (1987) Turnover of brain monoamine oxidase measured in vivo by positron emission tomography using L- [11C ] deprenyl. J Neurochem 49: 522-527

Aquilonius S-M. , Bergström K. , Eckernäs S.A. , Hartvig P. , Leenders K.L. , Lundqvist H. , Antoni G. , Gee A. , Rimland A. , Uhlin J. , Langström B. (1987) In vivo evaluation of striatal dopamine reuptake sites using 11C-nomifensine and positron emission tomography. Acta Neurol Scand 76: 283-287

Barrio J.R. , Satyamurthy N. , Huang S-C. , Keen R.E. , Nissenson C H K , Hoffman J.M. , Ackerman R.F. , Bahn M.M. , Mazziotta J.C. , Phelps M.E. (1989) 3-(2'- [18F] fluoroethyl)spiperone: in vivo biochemical and kinetic characterisation in rodents, non human primates, and humans. J Cerebr Blood Flow Metab 9: 830

Bartenstein P.A. , Duncan J.S. , Fish DR , Sawle G.V. , Luthra S.K. , Frackowiak R S F (1991) 11C-Diprenorphine in generalised absence seizures. J Nucl Med 32: 960 (Abstract)

Belliveau J.W. , Kennedy D.N. , McKinstry R.C. , Buchbinder B.R. , Weiskoff R.M. , Cohen M.S. , Verea J.M. , Brady T.J. , Rosen B.R. (1991) Functional mapping of the human visual cortex by magnetic resonance imaging. Science 254: 716-719

Bench C.J. , Price G.W. , Lammertsma A.A. , Cremer J.C. , Luthra S.K. , Turton D. , Dolan R.J. , Kettler R. , Dingemanse J. , Da Prada M. , Biziere K. , McClelland G.R. , Jamieson V.L. , Wood N.D. , Frackowiak R.S. (1991) Measurement of human cerebral monoamine oxidase type B (MAO-B) activity with positron emission tomography (PET): a dose ranging study with the reversible inhibitor Ro 19-6327. Eur J Clin Pharmacol 40: 169-173

Blin J. , Pappata S. , Kiyosawa M. , Crouzel C. , Baron J.C. (1988) [18F ] Setoperone: a new high affinity ligand for positron emission tomography. Eur J Pharmacol 147: 73-82

Bottlaender M. , Brouillet E. , Varaste M. , Sitbon R. , Fournier D. , Mazière B. , Mazière M. (1992) In vivo interaction of triazolam with central type benzodiazepine receptors in baboons; a PET study. J Nucl Med 33: 973 (Abstract)

Chi D.Y. , Kilbourn M.R. , Katzenellenbogen J.A. , Brodack J.W. , Welch M.J. (1986) Synthesis of no-carrier-added N-( [18F] fluoroalkyl)-spiperone derivatives. Int J Appl Radiat Isot 37: 1173-1180

Chugani D.C. , Ackermann R.F. , Phelps M.E. (1988) In vivo [3H] spiperone binding: evidence for accumulation in corpus striatum by agonist-mediated receptor internalization . J Cerebr Blood Flow Metab 8: 291-303

Coenen H.H. , Laufer P. , Stöcklin G. , Wienhard K. , Pawlik G. , Böcher-Schwartz H.G. , Heiss W. -D (1987) 3-N-(2'[18F]-fluoroethyl)-spiperone : a novel ligand for cerebral dopamine receptor studies with PET. Life Sci 40: 81-88

Coenen H.H. , Wienhard K. , Stöcklin G. , Laufer P. , Heboldt I. , Pawlik G. , Heiss W-D. (1988) PET measurement of D2 and S2 receptor binding of 3-N-(2'-18F] fluoroethylspiperone in baboon brain. Eur J Nucl Med 14: 80-87

Crouzel C. , Guillaume M. , Barré L. , Lemaire C. , Pike V.W. (1992) Ligands and tracers for PET studies of the 5HT system—Current status. J Nucl Med Biol 19: 857-870

Cunningham V.J. , Pike V.W. , Bailey D. , Freemantle C A J , Page B.C. , Jones A K P , Kensett M.J. , Bateman D. , Luthra S.K. , Jones T. (1991) A method for studying pharmacokinetics in man at picomolar drug concentrations. Br J Clin Pharmacol 32: 167-172

de Paulis T. , Schmidt D. , Clanton J.A. , Ansari M.S. , Holdeman KP , Pfeffer R. , Manning RG (1990a) [I123]Labelled epidepride SPECT studies of dopamine D2 receptors in man. J Nucl Med 31: 779 (Abstract)

de Paulis T. , Schmidt D. , Ansari M.S. , Kessler R.M. (1990b) [18F] Fluvepride: the design and synthesis of PET ligands for the dopamine D2 receptor. J Nucl Med 31: 786-787 (Abstract)

de Paulis T. , Bingham R. , Manning R.G. , Mason N.S. , Ansari M.S. , Schmidt D.E. , Kessler R.M. (1991) Design and radiofluorination of benzamide dopamine D2 receptor ligands. In Emran A M (ed.), New trends in radiopharmaceutical synthesis, quality assurance and regulatory control. Plenum Press, New York, pp. 97-107

Doble A. , Martin I.L. (1992) Multiple benzodiazepine receptors: no reason for anxiety. Trends Pharmacol Sci 13: 76-81

Eckelman W.C. (1982) Receptor specific radiopharmaceuticals. In Ell P J , Holman B L J (eds), Computed emission tomography. Oxford University Press, p. 263

Farde L. , Ehrin E. , Eriksson L. , Greitz T. , Hall H. , Hedstrom C-G. , Litton J-E. , Sedvall G. (1985) Substituted benzamides as ligands for visualization of dopamine receptors in the human brain by positron emission tomography. Proc Natl Acad Sci USA 82: 3863-3867

Farde L. , Hall H. , Ehrin E. , Sedvall G. (1986) Quantitative analysis of dopamine D2 receptor binding in the living brain by positron emission tomography. Science 231: 258-261

Farde L. , Halldin C. , Stone-Elander S. , Sedvall G. (1987a) PET analysis of human dopamine receptor subtypes using 11C-SCH 23390 and 11C-raclopride. Psychopharmacology 92: 278-284

Farde L. , Wiesel F-A. , Hall H. , Halldin C. , Stone Elander S. , Sedvall G. (1987b) No D2 receptor increase in PET study of schizophrenia . Arch Gen Psychiatr 44: 671-672 Farde L. , Wiesel F-A. , Halldin C. , Sedvall G. (1988) Central D2-dopamine receptor occupancy in schizophrenic patients treated with antipsychotic drugs. Arch Gen Psychiatr 45: 71-78

Farde L. , Eriksson L. , Blomquist G. , Halldin C. (1989a) Kinetic analysis of central [11C]raclopride binding to D2-dopamine receptors studied by PET-a comparison to the equilibrium analysis. J Cerebr Blood Flow Metab 9: 696-708

Farde L. , Wiesel F-A. , Nordström A.L. , Sedvall G. (1989b) D1 and D2-dopamine receptor occupancy during treatment with conventional and atypical neuroleptics. Psychopharmacology 99: S28-S31

Farde L. , Wiesel F-A. , Stone-Elander S. , Halldin C. , Nordström A-L. , Hall H. , Sedvall G. (1990) D2 Dopamine receptors in neuroleptic-naive schizophrenic patients—a PET study with [11C]raclopride. Arch Gen Psychiatr 47: 213-219

Farde L. , Nordström A-L. , Wiesel F-A. , Pauli S. , Halldin C. , Sedvall G. (1992) Positron emission tomography analysis of central D1 and D2-dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine— relation to extrapyramidal side effects. Arch Gen Psychiatr 49: 538-544

Firnau G. , Garnett E.S. , Chirakal R. , Sood S. , Nahmias C. , Schrobilgen G. (1986) [18F] Fluoro-L-dopa for the in vivo study of intracerebral dopamine. Appl Radiat Isot 37: 669-676

Fowler J.S. , Wolf A.P. (1986) 2-Deoxy-2- [18F] fluoro-D-glucose for metabolic studies: current status. Appl Radiat Isot 37: 663-668

Fowler J.S. , MacGregor R R. , Wolf A.P. , Arnett C.D. , Dewey S.L. , Schlyer D. , Christman D. , Logan J. , Smith M. , Sachs H. , Aquilonius S.M. , Bjurling P. , Halldin C. , Hartvig P. , Leenders K.L. , Ludqvist H. , Oreland L. , Stalnacke C-G. , Långström B. (1987) Mapping human brain monoamine oxidase A and B with 11C-labelled suicide inactivators and PET. Science 235: 481-485

Fowler J.S. , Volkow N.D. , Wolf A.P. , Dewey S.L. , Schlyer D.J. , MacGregor R R. , Hitzemann R. , Logan J. , Bendriem B. , Gatley J. , Christman D. (1989) Mapping cocaine binding sites in human and baboon brain in vivo. Synapse 4: 371-377

Fowler J.S. , Volkow N.D. , Logan J. , MacGregor R R. , Wang G-J. , Wolf A.P. (1992) Alcohol intoxication does not change the distribution and kinetics of cocaine in human brain and heart. J Nucl Med 33: 946 (Abstract)

Frost J.J. , Wagner H.N. , Dannals R.F. , Ravert H Y T , Limbs J.M. , Wilson A.A. , Burns H.D. , Wong D.F. (1985) Imaging opiate receptors in the human brain by positron tomography. J Comput Assist Tomogr 9: 231-236

Gibson R.E. , Eckelman W.C. , Rzeszotarski W.J. , Jiang V. , Mazaitis A. , Paik C. , Komai T. , Reba R.C. (1979) Radiotracer localization by receptor-ligand interactions . In Colombetti L G (ed.), Principles of pharmacology Vol. II. CRC Press, Boca Raton, FL, USA, p. 17

Halldin C. (1991) Radioligands for dopamine receptor PET studies: benzamides and ligands for the dopamine D-1 receptors. In Baron J C , Comar D , Farde L , Martinot J L , Mazoyer B (eds), Brain dopaminergic systems with positron tomography. Kluwer Academic Publishers, Netherlands, pp. 23-38

Halldin C. , Stone-Elander S. , Farde L. , Ehrin E. , Fasth K-J. , Långström B. , Sedvall G. (1986) Preparation of 11C-labelled SCH 23390 for the in vivo study of dopamine D-1 receptors using positron emission tomography . Appl Radiat Isot 37: 1039-1043

Halldin C. , Farde L. , Hogberg T. , Hall H. , Ohlberger A. , Solin O. (1991) A comparative PET-study of five carbon-11 or fluorine-18 labelled salicylamides. Preparation and in vitro dopamine D-2 receptor binding . Nucl Med Biol 18: 871-881

Halldin C. , Farde L. , Litton J.E. , Hall H. , Sedvall G. (1992) [11C] Ro 15-4513, a ligand for visualization of benzodiazepine receptor binding. Preparation, autoradiography and positron emission tomography. Psychopharmacology 108: 16-22

Hamacher K. , Coenen HH , Stöcklin G. (1986) N.c.a. radiofluorination of spiperone and N-methylspiperone via aminopolyether supported direct nucleophilic substitution. J Label Compounds Radiopharm 23: 1047 (Abstract)

Hansch C. , Leo A.J. (1979) The FRAGMENT method of calculating partition coefficients. In Substituent constants for correlation analysis in chemistry and biology . John Wiley, New York, pp. 18-43

Hansch C. , Bjorkroth J.P. , Leo A. ( 1987) Hydrophobicity and central nervous system agents: the principle of minimal hydrophobicity in drug design. J Pharm Sci 76: 663-687

Jones A K P , Luthra S.K. , Pike V.W. , Herold S. , Brady F. (1985) New labelled ligand for in-vivo studies of opioid physiology. Lancet ii: 665-666

Jones A K P , Luthra S.K. , Mazière B. , Pike V.W. , Loc'h C. , Crouzel C. , Syrota A. , Jones T. (1988) Regional cerebral opioid receptor studies with [11C] diprenorphine in normal volunteers. J Neurosci Methods 23: 121-129

Jones A K P , Friston K.J. , Qi L.Y. , Harris M. , Cunningham V.J. , Jones T. , Feinman C. , Frackowiak R S J (1991) Sites of action of morphine in the brain. Lancet ii: 338, 825

Jones A K P , Kawa S K H , Fujiwara T. , Li Q. , Luthra S.K. , Ashburner J. , Osman S. , Jones T. (1992) Quantification of 11C-diprenorphine cerebral kinetics in man acquired by PET using presaturation, pulse dose and tracer alone protocols. J Cerebr Blood Flow Metab (in press)

Kilbourn M.R. (1990) Fluorine-18 labelling of radiopharmaceuticals. Nuclear Science Series NAS-NS3203, National Academy Press , Washington DC

Lannoye G.S. , Moerlein S.M. , Parkinson D. , Welch M.J. (1990) N-Fluoroalkylated and N-alkylated analogues of the dopaminergic D-2 receptor antagonist raclopride. J Med Chem 33: 2430-2437

Lee M.C. , Wagner H.N. , Tanada S. , Frost J.J. , Bice A.N. , Dannals R.F. (1988) Duration of occupancy of opiate receptors by naltrexone . J Nucl Med 29: 1207-1211

Leenders K.L. , Aquilonius S.M. , Bergström K. , Bjurling P. , Crossman A.R. , Eckernås S.A. , Gee A. , Hartvig P. , Lundquist H. , Langström B. , Rimland A. , Tedroff J. (1988) Unilateral MPTP lesion in a rhesus monkey, effect on the striatal dopaminergic system measured in vivo with PET using various novel tracers. Brain Res 445: 61-67

Leo A. , Hansch C. , Elkins D. (1971) Partition coefficients and their uses. Chem Rev 71: 525-616

Leysen J.E. , Gommeren W. (1984) The dissociation rate of unlabelled dopamine antagonists and agonists from the dopamine-D receptor, application of an original filter method. J Receptor Res 4: 817-845

Litton J. , Farde L. , Neiman J. , Halldin C. , Sedvall G. (1991) Positron emission tomography of benzodiazepine receptors binding in alcoholics—equilibrium quantification. J Cerebr Blood Flow Metab 11 (Suppl.): 617

Logan J. , Fowler J.S. , Volkow N.D. , Wolf A.P. , Dewey S.L. , Schlyer D.J. , MacGregor R R. , Hitzmann R. , Bendriem B. , Gatley S.J. , Christman DR (1990) Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-methyl-11C]-(-)cocaine PET studies in human subjects. J Cerebr Blood Flow Metab 10: 740-747

London E.R. , Fanelli R. , Sziksy M. , Jasinski D. (1987) Effects of opioid analgesics on local cerebral glucose utilization. In Holladay J , Law P-Y , Henz A (eds), Progress in opioid research. NIDA Research monograph 75. pp. 379-381

Luthra S.K. , Pike V.W. , Brady F. (1985) The preparation of carbon-11 labelled diprenorphine: a new radioligand for the study of the opiate receptor system in vivo. J Chem Soc Chem Commun 1423-1425

Luthra S.K. , Turton DR , Dowsett K. , Bateman D.M. , Kensett M.J. , Waters S.L. , Pike V.W. (1989) Improved and automated one-pot radiosynthesis of [11C] diprenorphine and [11C] buprenorphine. J Label Compounds Radiopharm 30: 258-259 (Abstract)

Mazière B. , Coenen H.H. , Halldin C. , Någren K. , Pike V.W. (1992) PET radioligands for dopamine receptors and reuptake sites: chemistry and biochemistry. Nucl Med Biol 19: 497-512

Mazoyer B.M. (1991) Investigation of the dopamine system with positron emission tomography: general issues in modelling. In Baron J C , Comar D , Farde L , Martinot J L , Mazoyer B (eds), Brain dopaminergic systems: imaging with positron tomography. Kluwer Academic Publishers , Netherlands, pp. 181-189

Moerlein S.M. , Laufer P. , Stöcklin G. (1985) Effect of lipophilicity on the in vivo localization of radiolabelled spiperone analogues. Int J Nucl Med 12: 353-356

Nordström A-L. (1991) Measurement of dopamine receptor occupancy; clinical issues. In Baron J C , Comar D , Farde L , Martinot J L , Mazoyer B (eds), Brain dopaminergic systems: imaging with positron tomography . Kluwer Academic Publishers, Netherlands, pp. 191-198

Nordström A-L. , Farde L. , Halldin C. (1992a) Time course of D2-dopamine receptor occupancy examined by PET after single oral doses of haloperidol. Psychopharmacology 106: 433-438

Nordström A-L. , Farde L. , Wiesel F-A. , Orslund K. , Halldin C. , Uppfeldt G. (1992b) D2-Dopamine receptor occupancy and antipsychotic effect in raclopride treated schizophrenics. Ann Univ Turkuensis Ser D88: A97-A98 (Abstract)

Nyberg S. , Farde L. , Halldin C. , Eriksson B. (1992a) PET examination of central D2 dopamine and 5HT2 receptor occupancy by risperidone. CINP XVIIIth Congress, Nice, July 1992

Nyberg S. , Farde L. , Halldin C. , Eriksson L. , Eriksson B. (1992b) Determination of 5-HT2 receptor occupancy in the living human brain [11C] NMSP—a PET study with risperidone . Submitted to 2nd International Symposium on Serotonin from Cell Biology to Pharmacology and Therapeutics, Houston , USA, September 1992

Ogawa S. , Tank T.W. , Menon R. , Ellerman J.R. , Kim S-G. , Merkle H. , Uginbil K. (1992) Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci USA: 89: 5951-5955

Pauli S. , Farde L. , Halldin C. , Sedvall G. (1992) Benzodiazepine receptor occupancy during benzodiazepine treatment measured by PET in the living brain. Ann Univ Turkuensis Ser D88: A101-A102

Persson A. , Ehrin E. , Eriksson L. , Farde L. , Hedström C-G. , Litton J-E. , Mindus P. , Sedvall G. (1985) Imaging of 11C-labelled Ro 15-1788 binding to benzodiazepine receptors in the human brain by positron emission tomography . J Psychiatr Res 19: 609-622

Pike V.W. (1988) Organic synthesis with short-lived positron-emitting radioisotopes. In Jones J R (ed.), Isotopes: essential chemistry and applications II. Special Publication No 68, Royal Society of Chemistry, London, 1988, pp. 1-39

Pike V.W. , Halldin C. , Crouzel C. , Barré L. , Nutt D.J. , Osman S. , Shah F. , Turton D.R. , Waters S.L. (1992) Radioligands for PET studies of central benzodiazepine receptors and PK (peripheral benzodiazepine) binding sites—Current status . J Nucl Med Biol (in press)

Rajeswaren S. , Bailey DL , Hume S.P. , Townsend D.W. , Geissbuhler A. , Young J. , Jones T. (1992) 2-D and 3-D Imaging of small animals and the human radial artery with a high resolution detector for PET. IEEE Trans Med Imaging 11: 386-391

Sadzot B. , Lemaire C. , Cantineau R. , Salmon E. , Plenevaux A. , Maquet P. , Hermanne J.P. , Frank G. , Guillaume M. (1990) Imaging serotonin-S2 receptors in humans with PET and the selective S2 antagonist [18F] altanserine. J Nucl Med 31: 1584 (Abstract)

Salmon E. , Brooks D.J. , Leenders K.L. , Turton D.R. , Hume S.P. , Cremer J.E. , Jones T. , Frackowiak R S J (1990) A two compartmental description and kinetic procedure for measuring regional cerebral [11C] nomifensine uptake using positron emission tomography. J Cerebr Blood Flow Metab 10: 307-316

Samson Y. , Hantraye P. , Baron J.C. , Soussaline F. , Comar C. , Maziere M. (1985) Kinetics and displacement of 11C-Ro 15-1788, a benzodiazepine antagonist, studied in human brain in vivo by positron tomography. Eur J Pharmacol 110: 274-251

Satymurthy N. , Barrio J.R. , Bida G.T. , Huang S-C. , Mazziotta J.C. , Phelps M.E. (1990) 3-(2'- [18F] fluorethyl)spiperone, a potent dopamine antagonist: synthesis, structural analysis and in-vivo utilization in humans. Appl Radiat Isot 41: 113-129

Schlyer D.J. , Volkow N.D. , Fowler J.S. , Wolf A.P. , Shiue C-Y. , Dewey S.L. , Bendriem B. , Logan J. , Raulli R. , Hitzemann R. , Brodie J. , Alavi A.A. , MacGregor R R. (1992) Regional distribution and kinetics of haloperidol binding in human brain: a PET study with [18F] haloperidol. Synapse 11: 10-27

Sedvall G. (1991) PET scanning as a tool in clinical psychopharmacology . Triangle 30: 11-20

Shinotoh H. , Yamasaki T. , Inoue E. , Itoh T. , Suzuki K. , Hashimoto K. , Tateno Y. , Ikehira H. (1986) Visualization of specific binding sites of benzodiazepine in human brain. J Nucl Med 27: 1593-1599

Shinotoh H. , Iyo M. , Yamada T. , Inoue O. , Susuki K. , Itoh T. , Fukuda H. , Yamasaki T. , Tateno Y. , Hirayama K. (1989) Detection of benzodiazepine receptor occupancy in the human brain by positron emission tomography. Psychopharmacology 99: 202-207

Simonyi M. , Fitos I. , Visy J. ( 1986) Chirality of bioactive agents in protein binding storage and transport processes. Trends Pharmacol Sci 7: 112-116

Smith M. , Wolf A.P. , Brodie J.D. , Arnett C.D. , Barouche I.F. , Shiue C-Y. , Fowler J.S. , Russel J A G , MacGregor R R. , Wolkin A. , Angrist B. , Rotrosen J. , Peselow E. (1988) Serial [18F] N-methylspiperone PET studies to measure changes in antipsychotic drug D-2 receptor occupancy in schizophrenic patients. Biol Psychiatr 23: 653-663

Sokoloff P. , Giros B. , Martres M.P. , Bouthenet M.L. , Schwartz J-C. (1990) Molecular cloning and characterisation of a novel dopamine receptor (D3) as a target for neuroleptics. Nature 347: 146-151

Stöcklin G. (1991) Radioligands for PET studies of D2-receptors : butyrophenones and ergot derivatives. In Baron J C , Comar D , Farde L , Martinot J L , Mazoyer B (eds), Brain dopaminergic systems: imaging with positron tomography. Kluwer Academic Publishers , Netherlands, pp. 5-22

Stöcklin G. (1992) Tracers for metabolic imaging of brain and heart. Radiochemistry and radiopharmacology. Eur J Nucl Med 19: 527-551

Suhara T. , Fukuda H. , Inoue O. , Itoh T. , Suzukiu K. , Yamasaki T. , Tateno Y. (1991) Age-related changes in human D1 dopamine receptors measured by positron emission tomography. Psychopharmacology 103: 41

Testa B. (1986) Chiral aspects of drug metabolism. Trends Pharmacol Sci 7: 60-64

Van Tol H H M , Bunzow J.R. , Guan H-C. , Sunahara R.K. , Seeman P. , Niznik H.B. , Civello O. (1991) Cloning of the gene for a human dopamine D 4 receptor with high affinity for the antipsychotic clozapine. Nature 350: 610-614

Van Tol H H M , Caren M.W. , Guan H-C. , Ohara K. , Bunzow J.R. , Civelli O. , Kennedy J. , Seeman P. , Niznik H.B. , Joanovic V. (1992) Multiple dopamine D4 receptor variants in the human population. Nature 358: 149-152

Verhoeff N P L G (1991) Pharmacological implications for neuroreceptor imaging. Eur J Nucl Med 18: 482-502

Volkow N.D. , Fowler J.S. , Logan J. , Wang G-J. , Hitzemann R. , MacGregor R. , Dewey S.L. , Wolf A.P. (1992) Decreased binding of [11C] cocaine in the brain of cocaine addicts. J Nucl Med 33: 888 (Abstract)

Wagner HN , Burns HD , Dannals RF , Wong DF , Långstrom B. , Duelfer T. , Frost J.J. , Ravert H.T. , Links J.M. , Rosenbloom S.B. , Lukas S.E. , Kramer A.V. , Kuhar M.J. (1983) Imaging dopamine receptors in the human brain by positron tomography. Science 221: 1264-1266

Walle T. , Walle U.K. (1986) Pharmacokinetic parameters obtained with racemates . Trends Pharmacol Sci 7: 155-158

Wienhard K. , Coenen H.H. , Pawlik G. , Rudolf J. , Laufer P. , Jovkar S. , Stöcklin G. , Heiss W-D. (1990) PET studies of dopamine receptor distribution using [18F ] fluoroethylspiperone ; findings in disorders related to the dopaminergic system. J Neural Transm 81: 195-213

Wolkin A. , Barouche F. , Wolf A.P. , Rotrosen J. , Fowler J.S. , Shiue C. Y, Cooper T.B. , Brodie J.D. (1989a) Dopamine blockade and clinical response: evidence for two biological subgroups of schizophrenia. Am J Psychiatr 46: 905-908

Wolkin A. , Brode J.D. , Barouche F. , Rotrosen J. , Wolf A.P. , Smith M. , Fowler J.S. , Cooper T.B. (1989b) Dopamine receptor occupancy and plasma haloperidol levels. Arch Gen Psychiatr 46: 482-483

Wong DF , Wagner H.N. Jr, Tune L.E. , Dannals RF , Pearlson G.D. , Links JM , Tamminga A.A. , Broussolle E.P. , Ravert H.T. , Wilson A.A. , Toung J K T , Malat J. , Williams J.A. , O'Tuama L.A. , Snyder S.H. , Kuhar M.J. , Gjedde A. (1986) Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. Science 234: 1558-1563

Zijlstra S. , Louwerens J.W. , Buddingh J.A. , Paans A M J , Visser G. , Sloof C.J. , Vaalburg W. , Korf J. ( 1991) The assessment of central D2-dopamine receptor occupancy with positron emission tomography in long-term medicated schizophrenic patients . In Baron J C , Comar D , Farde L , Martinot J L , Mazoyer B (eds), Brain dopaminergic systems: imaging with positron tomography . Kluwer Academic Publishers, Netherlands, pp. 181-189