The psychopharmacological profiles of 15 psychotropic drugs used as antidepressants are reviewed, and their relative behavioural toxicity ratings are compared. The pharmacodynamic activity of these drugs was assessed using a standardized test battery which included critical flicker fusion threshold (CFF), choice reaction time (CRT), tracking and subjective rating scales. It is reported that there is a wide range of behavioural toxicity exhibited by these compounds, although there is little measurable difference in their clinical efficacy. Drugs which have low behavioural toxicity should therefore be preferred as they are less disruptive of patients' everyday activities, produce better quality of life and are not counter-therapeutic.
Alford C., Hindmarch I. (1989) Measuring the effects of psychoactive drugs, with particular reference to antidepressants. In West R (ed.), Microcomputers, psychology and medicine. John Wiley and Sons, Chichester, pp. 85-95
2.
Baldessarini R.J. (1985) Drugs and the treatment of psychiatric disorders . In Goodman A, Gilman L S (eds), The pharmacological basis of therapeutics . Macmillan, New York
3.
Birren J.E., Woods A.M., Williams M.V. (1980) Behavioural slowing with age: causes, organisation and consequences. In Pook, L W (ed.), Aging in the 1980s: psychological issues. APA, Washington DC
4.
Bobon D.P., Lecoq A., Von Frenckell R., Mormont I., Laverque G., Lottin T. (1982) La frequence critique de fusion visuelle en psychopathologie et en pharmacologie. Acta Med Belge82: 1-112
5.
Cohen R.M., Weingartner H., Smalberg S.A. et al. (1982) Effort and cognition in depression. Arch Gen Psychiatr39: 593
6.
Curran H.V., Sakulsriprong M., Lader M. (1988) Antidepressants and human memory: An investigation of four drugs with different sedative and anticholinergic profiles. Psychopharmacology95: 520-527
7.
Curran S., Wattis J.P., Robertson C., Baksi A.K., Hindmarch I. (1990) A possible role for two psychometric measures, critical flicker fusion threshold (CFFT) and choice reaction time (CRT) in the assessment of primary degenerative dementia—a preliminary report . Pharmacopsychoecologia3: 17-24
8.
Gilburt S., Hindmarch I. (1989) An investigation of the CNS effects of nizatidine, with and without alcohol on psychomotor functioning in the elderly. Pharmacopsychoecologia2: 13-20
9.
Glass G.V., Kliegl R.M. (1983) An apology for research integration in the study of psychotherapy. J Consult Clin Psychol51: 28
10.
Hanks GW (1984) The effects of amitriptyline and nomifensine on critical flicker fusion threshold in an elderly patient population. In Linford-Rees W, Priest R G (eds), Nomifensine: a pharmacological and clinical profile. Royal Society of Medicine International Congress and Symposium Series, No. 70. Oxford University Press, Oxford, pp. 87-94
11.
Hindmarch I. (1975) A 1,4-benzodiazepine, temazepam (K 3917), its effect on some psychological parameters of sleep and behaviour. Arzn-Forsch (Drug Res)11: 1836Hindmarch I. (1980) Psychomotor function and psychoactive drugs. Br J Clin Pharmacol10: 189-209
12.
Hindmarch I. (1981) Measuring the effects of drugs on higher brain function. In Burrows G D, Werry J S (eds), Advances in human psychopharmacology II. JAI, Connecticut, pp.99-128
13.
Hindmarch I. (1982) Critical flicker fusion frequency (CFFF): the effects of psychotropic compounds. Pharmacopsychiatrica15 Suppl. 1: 44-48
14.
Hindmarch I. (1986) The effects of psychoactive drugs on car handling and related psychomotor ability: A review. In O'Hanlon J F, de Gier J J (eds), Drugs and driving. Taylor and Francis, London, pp. 71-79
15.
Hindmarch I. (1987a) Antidepressant drugs and cognitive function. In Biziere K, Garattini S, Simon P (eds), Quo vadis—diagnosis and treatment of depression. Medsi/ McGraw, Paris, pp. 355-364
16.
Hindmarch I. (1987b) Three antidepressants (amitriptyline, dothiepin, fluoxetine), with and without alcohol, compared with placebo on tests of psychomotor ability related to car driving. Hum Psychopharmacol2: 177
17.
Hindmarch I. (1988a) Information processing, critical flicker fusion threshold and benzodiazepines: results and speculations. In Hindmarch I, Ott H (eds), Benzodiazepine receptor ligands, memory and information processing . Springer-Verlag, Heidelberg, pp. 78-89
18.
Hindmarch I. (1988b) Lofepramine and psychomotor function. Int Clin Psychopharmacol3 Suppl. 2: 71-77
19.
Hindmarch I., Parrott A.C. (1977) Repeated dose comparisons of nomifensine, imipramine and placebo on subjective assessments of sleep and objective measures of psychomotor performance. Br J Clin Pharmacol4: 167S-173S
20.
Hindmarch I., Parrot A.C. (1978) A repeated dose comparison of the side effects of five antihistamines on objective assessments of psychomotor performance, central nervous system arousal and subjective appraisals of sleep and early morning behaviour. Arzn-Forsch (Drug Res)28 Suppl. 1: 483
21.
Hindmarch I., Gudgeon A.C. (1980) The effects of clobazam and lorazepam on aspects of psychomotor performance and car handling ability. Br J Clin Pharmacol10: 145Hindmarch I., Subhan Z. (1986) The effects of antidepressants taken with and without alcohol on information processing, psychomotor performance and car handling ability. In O'Hanlon, J F , de Gier, J J (eds), Drugs and driving. Taylor and Francis, London, pp. 231-239
22.
Hindmarch I., Bhatti J.Z. (1987) Psychomotor effects of astemizole and chlorpheniramine, alone and in combination with alcohol. Int Clin Psychopharmacol2: 117Hindmarch I., Bhatti J.Z. (1988) Psychopharmacological effects of sertraline in normal, healthy volunteers. Eur J Clin Pharmacol35: 221-223
23.
Hindmarch I., Harrison C. (1988a) Three antidepressants (amitriptyline, dothiepin, fluoxetine) with and without alcohol, compared with placebo on tests of psychomotor ability related to car driving. Hum Psychopharmacol2: 177-183
24.
Hindmarch I., Harrison C. (1988b) The effects of paroxetine and other antidepressants in combination with alcohol, in psychomotor activity related to car driving . Hum Psychopharmacol3: 13-20
25.
Hindmarch I., Kerr J.S. (1991) The behavioural toxicity of antidepressants with particular reference to moclobemide. Psychopharmacology (in press)
26.
Hindmarch I., Subhan Z., Stoker M.J. (1983) The effects of zimeldine and amitriptyline on car driving and psychomotor performance. Acta Psychiatr Scand68 (Suppl. 308): 141Hindmarch I., Harrison C., Shillingford C.A. (1988) An investigation of the effects of lofepramine, nomifensine, amitriptyline and placebo on aspects of memory and psychomotor performance related to car driving. Int Clin Psychopharmacol3: 157
27.
Hindmarch I., Kerr J.S., Sherwood N. (1990a) Psychopharmacological aspects of psychoactive substances. In Warburton, D (ed.), Addiction controversies. Harwood Academic, London, pp. 36-44
28.
Hindmarch I., Baksi A., Shillingford C., Guillon Y. (1990b) Effects of JO 1017, a new 5HT reuptake inhibitor, on psychoperformance and cognitive function. Unpublished Report, The Robens Institute, University of SurreyJacobs D. (1986) Noradrenergic mechanisms in the response to dextroamphetamine in humans. Int Clin Pharmacol1: 199-209
29.
Joanny P., Azorin J.M., Piron J.J., Tomei C., Oppenheim G., Millet Y., Papy J.J. (1991) Effect of acute and subchronic treatment with trimipramine, atricyclic antidepressant, on sleep-waking cycle in rat. Sleep Res20A: 143
30.
Khan M.C., Mahapatra S.N., Stonier P.D., Thomas E.M. (1984) Nomifensine and mianserin: non-tricyclic antidepressants with distinct clinical profiles: a randomised double-blind study. In Linford Rees W, Priest R G (eds), Nomifensine: a pharmacological and clinical profile. Royal Society of Medicine International Congress and Symposium Series No. 70. Oxford University Press, Oxford, pp. 71-76
31.
Kielholz P. (1965) Psychiatrische pharmakotherapie in Klinik und Praxis . Verlag Huber, Stuttgart
32.
Kielholz P. (1984) Die Pharmakotherapie von somatisierter Angst und Depression. In Poldinger R W (ed.), Karger, Basel, pp. 416-420
33.
Millichap J.G. (1968) Drugs in management of hyperkinetic and perceptually handicapped children. J Am Med Assoc206: 1527-1530
34.
Molle J-P., Quarré J.-P, Gilbert P., Ligny C., Machowski R., Schittecatte M., Wilmotte J. (1991) Influence of zopiclone on nocturnal oxygen saturation in patients with mild chronic obstructive pulmonary disease. Sleep Res20A: 161
35.
Mullen B., Rosenthal R. (1985) Basic meta-analysis: procedures and programs. Lawrence Erlbaum Associates, New Jersey
36.
Parrott A.C. (1982) Critical flicker fusion thresholds and their relationship to other measures of alertness. Pharmacopsychiatrica15: 39-44
37.
Pinder R.M. (1987) Psychopharmacological profiling of antidepressants . In Hindmarch I, Stonier P D (eds), Human psychopharmacology: vol I—measures and methods. John Wiley and Sons, Chichester, pp. 219-234
38.
Rosenthal R., Rosnow R. (1985) Contrast analysis: focused comparisons in the analysis of variance. Cambridge University Press, Cambridge
39.
Siegfried K. (1989) Towards a clinical classification of antidepressant profiles. In Hindmarch I, Stonier P D (eds), Human psychopharmacology: volume 2—measures and methods. John Wiley and Sons , Chichester, pp. 141-154
40.
Siegfried K., Jansen W., Pahnke K. (1984) Cognitive dysfunction in depression. Drug Dev Res4: 533
41.
Thomson P.J. (1991) Antidepressants and memory: A review. Hum Psychopharmacol6: 79-90
42.
Weckowics T.E., Tam C., Mason J., Bay V.S. (1978) Speed in the test performance in depressed patients . J Abnormal Psychol87: 578
43.
Widlocher D.J. (1983a) Psychomotor retardation: clinical, theoretical and psychometric aspects. In Akiskal H S (ed.), The psychiatric clinics of North America, Vol 6. W B Saunders, Philadelphia , pp. 27-40
44.
Widlocher D.J. (1983b) Retardation: a basic emotional response? In Davis J, Maas J (eds), The affective disorders. American Psychiatric Press, New York.
45.
Widlocher D.J., Ghozlan A. (1989) The measurement of retardation in depression. In Hindmarch I, Stonier P D (eds), Human psychopharmacology: Volume 2—measures and methods. John Wiley and Sons, Chichester, pp. 1-22
46.
Yerkes R.M., Dodson J.M. (1908) The relation of strength of stimulus to rapidity of habit formation. J Comp Neurol Psychol18: 459-482
