The effects of sulpiride, dothiepin, diazepam and placebo were compared in out-patients who were suffering from depressive states of moderate severity. No major differences were found between the regimens after 4 weeks administration. A notable finding was the high recovery rate among those patients who received the placebo. The need for drug treatment in the milder depressive states is discussed.
Get full access to this article
View all access options for this article.
References
1.
Åsberg M., Cronholm B., Sjöquist F., Task D. ( 1970) Correlation of subjective side effects with plasma concentrations of nortriptyline. Br Med J4: 18-21
2.
Aylward M., Maddock J., Dewland P.M., Lewis P.A. (1981) Sulpiride in depressive illnessAdv Biol Psychiatr7: 154-165
3.
Blashki T.G., Mowbray R., Davies B. (1971) A controlled trial of an antidepressant (Amitryptyline) in general practiceBr Med J1: 133-138
4.
Catalan J., Gath D., Edmonds G., Ennis J. (1984) The effects of non-prescribing of anxiolytics in general practiceBr J Psychiatr144: 593-610
5.
Frølund F. (1974) Treatment of depression in general practice: a controlled trial of flupenthixolCurr Med Res Opinion2: 78-89
6.
Jenner P., Marsden C.D. (1979) The substituted benzamides—a novel class of dopamine antagonistsLife Sci25: 479-486
7.
Johnson D A W (1983) Benzodiazepine in depression In Trimble M R (ed.), Benzodiazepines divided.Chichester , Wiley, pp. 247-259
8.
Merskey H. (1971) FlupenthixolBr J Psychiatr119: 230
9.
Montgomery S.A., Åsberg M. (1979) A new depression scale designed to be sensitive to changeBr J Psychiatr134: 382-389
10.
Ovhed I. (1976) A double-blind study of flupenthixol in general practiceCurr Med Res Opinion4: 144-150
11.
Paykel E.S., Price J.S., Gillan R.N., Palmai G., Chesser E.S. (1968) A comparative trial of imipramine and chlorpromazine in depressed patientsBr J Psychiatr114:1281-1287
12.
Reiter P.J. (1969) On flupenthixol, an antidepressant of a new chemical groupBr J Psychiatr115: 1399-1401
13.
Robertson M.M., Trimble M.R. (1981) The antidepressant action of flupenthixolPractitioner225: 761-763
14.
Snaith R.P., Bridge G W K, Hamilton M. (1976) The Leeds Scales for the self-assessment of anxiety and depressionBr J Psychiatr128: 156-165
15.
Snaith R.P., Harrop F.M., Newby D.A., Teale C. (1986) Grade scores of the Montgomery-Åsberg depression and the clinical anxiety scalesBr J Psychiatr148: 599-601
16.
Standish-Barry H M S, Bouras N., Bridges P.K., Watson J.P. (1983) A randomized double blind comparative study of sulpiride and amitriptyline in affective disorderPsychopharmacology81: 258-260
17.
Tiller J., Schweitzer I., Maguire K., Davies B. (1989) Is diazepam an anti-depressant?Br J Psychiatr155: 483-489
18.
Young J P R, Hughes W.C., Lader M.H. (1976) A controlled comparison of flupenthixol and amitriptyline in depressed out-patientsBr Med J1: 1116-1118
