The 5-HT1A receptor has been studied using quantitative tritium film auto radiography in post-mortem frontal cortex of 15 cases suffering from major depression and controls matched for age, sex, post-mortem delay and storage time. 5-HT1A receptor binding in the depressive cohort was not significantly different from control values. No consistent effects of antidepressant medication or mental state at death were seen on the results.
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