Forty-four patients given midazolam prior to day-care urological surgery had the benzodiazepine antagonist, flumazenil, or placebo administered postoperatively. Flumazenil reversed the psychomotor impairments induced by midazolam but not its amnesic effects. There was no evidence of resedation for up to 6 h following the use of flumazenil.
Get full access to this article
View all access options for this article.
References
1.
Birch B R P, Anson K.M., Gelister J., Parker C., Bell J., Little S., Miller R.A. (1990) The role of midazolam and flumazenil in urologyActa Anaesthesiol Scand32 (supplement 1), 25-32
2.
Curran H.V. (1986) Tranquillising memories: a review of the effects of benzodiazepines on human memoryBiol Psychol23, 179-213.
3.
Curran H.V., Schiwy W., Lader M. (1987) Differential amnesic properties of benzodiazepines: a dose-response comparison of two drugs with similar elimination half-livesPsychopharmacology92, 358-364.16
4.
Curran H.V., Allen D., Lader M. (1987) The effects of single doses of alpidem and lorazepam on memory and psychomotor performance in normal humansJ Psychopharmacol1, 81-89.
5.
Darragh A., Lambe R., Kenny M., Brick I., Taafe W.O., Boyle C. (1982) Rol5-1788 antagonises the central effects of diazepam in man without altering diazepam bioavailabilityBrit J Clin Pharmacol14, 677-682.
6.
Dorow R., Duka T. ( 1986) Anxiety: its generation by drugs and their withdrawal In Bggio G, Costa E (eds) GABAergic transmission and anxiety, Raven, New York, pp 221-225.
7.
Dorow R., Berenberg D., Duka T., Sauerbreg N. (1987) Amnestic effects of lormetazepam and their reversal by the benzodiazepine antangonist Rol5-1788Psychopharmacology93 (4), 507-514.
8.
Dundee J.W., Halliday N.J., Harper K.W., Brogden R.N. (1984) Midazolam: a review of its pharmacological properties and therapeutic useDrugs28, 519-543
9.
Dunton A.W., Schwam E., Pitman V., McGrath J., Hendler J., Siegel J. (1988) Flumazenil: US clinical pharmacology studiesEur J AnaethesiolS2, 81-95
10.
Frith C.D. (1967) The effects of nicotine on tappingLife Sci6, 321-326
11.
Haefely, W. (1985) Tranquillisers In Graham-Smith D G, Cowen P J Psychopharmacology 2, Part 1, Preclinical psychopharmacology , Elsevier, Amsterdam
12.
Hanno P.M., Wein A.E. (1983) Anaesthetic techniques for cystoscopy in menJ Urol130, 1070-1072
13.
Hommer D.W., Breier A., Paul S.M., Davis M., Weingartner H. (1986) Rol5-1788, a specific benzodiazepine antagonist, blocks and sedative, anxiolytic and attentional but not the amnestic effects of diazepam in humansAbstracts of the 25th ACNP Annual Meeting in Washington
14.
Langlois S., Kreeft J., Chouinard G., Ross-Chouinard, A., East S., Ogilvie R. (1987) Mixazolam: kinetics and effects on memory, sensorium and haemodynamicsBrit J Clin Pharmacol23, 273-278
15.
Morre M., Bachy A., Keane P.E. (1985) Differential CNS binding of benzodiazepinesSuppl Actual Méd Inter Psychiatr2, 28-32
16.
O'Boyle C., Lambe R., Darragh A., Taffe W., Brick I., Kenny M. (1983) Rol5-1788 antagonizes the effects of diazepam in man without affecting its bioavailabilityBr J Anaesth55, 349-355
17.
Reitan J.A., Porter W., Braunstein M. (1986) Comparison of psychomotor skills and amnesia after induction of anaesthesia with midazolam and hisopentalAnesth Analg65, 933-937
18.
Rodrigo M.C., Clark R N W (1986) A study of intravenous sedation with diazepam and midazolam for dentistry in Hong Kong ChineseAnaesth Intensive Care14, 404-411.
19.
Rosenbaum N.L., Hopper P.A. (1988) The effects of flumazenil, a new benzodiazepine antagonist, on the reversal of midazolam sedation and amnesia in dental patientsBrit Dent J165, 400-402
20.
Wesnes K., Simpson P.M., Christmas L. (1987) The assessment of human information procession abilities in psychopharmacology In Hindmarch I, Stonier P D (eds). Human psychopharmacology: measures and methods, volume 1, John Wiley, Chichester , pp. 79-92