The effect on slow wave sleep (SWS) of 5-HT antagonists with different affinities for 5-HT1 and 5-HT2 receptors was investigated using ambulatory EEG monitoring in normal volunteers. The selective 5-HT 2 antagonists, ritanserin and cypropheptadine, increased SWS while the non-selective 5-HT antagonist metergoline did not. The histamine H 1-receptor antagonist, mepyramine, was similarly without effect on SWS. These findings suggest that home ambulatory monitoring with automatic sleep stage analysis may be useful in detecting the effect of selective 5-HT 2 receptor antagonists on SWS.
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