Antipsychotic action and symptom specificity – down the bioinformatic rabbit hole

Abstract

Get full access to this article

View all access options for this article.

References

Huhn

Nikolakopoulou

Schneider-Thoma

, et al. (2019) Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: A systematic review and network meta-analysis. Lancet 394(10202): 939–951.

Wang

Sampson

(2014) Sulpiride versus placebo for schizophrenia. Cochrane Database of Systematic Reviews 2014(4): CD007811.

Wright

McKenna

Tice

, et al. (2024) A network meta-analysis of KarXT and commonly used pharmacological interventions for schizophrenia. Schizophrenia Research 274: 212–219.

Zhuo

, et al. (2025) KarXT combines the partial benefits of haloperidol for positive symptoms and sulpiride for negative symptoms: Evidence from computational biology. Journal of Psychopharmacology 39(11): 1307–1319.