Over the past century, the polypeptide oxytocin has played an important role in medicine with major highlights including the identification of its involvement in parturition and the milk let-down reflex. Oxytocin is now implicated in an extensive range of psychological phenomena including reward and memory processes and has been investigated as a treatment for several psychiatric disorders including addiction, anxiety, autism, and schizophrenia. In this review, we first provide an historical overview of oxytocin and describe key aspects of its physiological activity. We then outline some pharmacological limitations in this field of research before highlighting the role of oxytocin in a wide range of behavioral and neuronal processes. Finally, we review evidence for a modulatory role of oxytocin with regard to psychostimulant effects. Key findings suggest that oxytocin attenuates a broad number of cocaine and methamphetamine induced behaviors and associated neuronal activity in rodents. Evidence also outlines a role for oxytocin in the prosocial effects of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) in both rodents and humans. Clinical trials should now investigate the effectiveness of oxytocin as a novel intervention for psychostimulant addiction and should aim to determine its specific role in the therapeutic properties of MDMA that are currently being investigated.
AhmedSH (2012) The science of making drug-addicted animals. Neuroscience211: 107–125.
2.
Al-AyadhiLY (2005) Altered oxytocin and vasopressin levels in autistic children in Central Saudi Arabia. Neurosciences (Riyadh)10: 47–50.
3.
AlfirevicZKellyAJDowswellT (2009) Intravenous oxytocin alone for cervical ripening and induction of labour. Cochrane Database Syst Rev4: CD003246.
4.
AlizadehAMFaghihiMSadeghipourHR. (2010) Oxytocin protects rat heart against ischemia reperfusion injury via pathway involving mitochondrial ATP-dependent potassium channel. Peptides31: 1341–1345.
5.
AndariEDuhamelJ-RZallaT. (2010) Promoting social behavior with oxytocin in high-functioning autism spectrum disorders. Proc Natl Acad Sci U S A107: 4389–4394.
6.
AntoniFA (1993) Vasopressinergic control of pituitary adrenocorticotropin secretion comes of age. Front Neuroendocrinol14: 76–122.
7.
ArmstrongWEHattonGI (2006) The puzzle of pulsatile oxytocin secretion during lactation: Some new pieces. Am J Physiol Regul Integr Comp Physiol291: R26–R28.
8.
AyersLWMissigGSchulkinsJ. (2011) Oxytocin reduces background anxiety in a fear-potentiated startle paradigm: Peripheral vs central administration. Neuropsychopharmacology36: 2488–2497.
9.
BalinBJBroadwellRDSalcmanM. (1986) Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey. J Comp Neurol251: 260–280.
10.
BaraczSJRourkePIPardeyMC. (2011) Oxytocin directly administered into the nucleus accumbens core or subthalamic nucleus attenuates methamphetamine-induced conditioned place preference. Behav Brain Res228: 185–193.
11.
BaraczSJCornishJL (in press) Oxytocin modulates dopamine-mediated reward in the rat subthalamic nucleus. Horm Behav.
12.
BargmannV (1949) Üeber die neurosekretorische verknüpfung von hypothalamus und neurophypophyse. Klin Wochenschr27: 617–622.
13.
BargmannWScharrerE (1951) The site of origin of the hormones of the posterior pituitary. Am Sci39: 255–259.
14.
BaskervilleTADouglasAJ (2010) Dopamine and oxytocin interactions underlying behaviors: potential contributions to behavioral disorders. CNS Neurosci Ther16: e92–e123.
15.
BaumgartnerTHeinrichsMVonlanthenA. (2008) Oxytocin shapes the neural circuitry of trust and trust adaptation in humans. Neuron58: 639–650.
16.
BediGHymanDde WitH (2010) Is ecstasy an “empathogen”? Effects of +/- 3,4-methylenedioxymethamphetamine on prosocial feelings and identification of emotional states in others. Biol Psychiatry68: 1134–1140.
17.
BellWB (1909) The pituitary body and the therapeutic value of the infundibular extract in shock, uterine atony, and intestinal paresis. Br Med J2: 1609–1613.
18.
BohusBUrbanIWimersmagreidanusTBV. (1978) Opposite effects of oxytocin and vasopressin on avoidance behaviour and hippocampal theta rhythm in the rat. Neuropharmacology17: 239–247.
19.
BornJLangeTKernW. (2002) Sniffing neuropeptides: A transnasal approach to the human brain. Nat Neurosci5: 514–516.
CarmichaelMSHumbertRDixenJ. (1987) Plasma oxytocin increases in the human sexual-response. J Clin Endocrinol Metab64: 27–31.
27.
CarsonDSBosanquetDPCarterCS. (2012a) Preliminary evidence for lowered basal cortisol in a naturalistic sample of methamphetamine polydrug users. Exper Clin Psychopharmacol20: 497–503.
28.
CarsonDSCornishJLGuastellaAJ. (2010a) Oxytocin decreases methamphetamine self-administration, methamphetamine hyperactivity, and relapse to methamphetamine-seeking behaviour in rats. Neuropharmacology58: 38–43.
29.
CarsonDSHermensDFGuastellaAJ. (2012b) Neurocognitive effects of amphetamine-type stimulants and implications for intervention. In: Perspectives on Amphetamine-Type (eds., AllsopSteveLeeNicole).Melbourne, Australia: IP Communications.
30.
CarsonDSHuntGEGuastellaAJ. (2010b) Systemically administered oxytocin decreases methamphetamine activation of the subthalamic nucleus and accumbens core and stimulates oxytocinergic neurons in the hypothalamus. Addict Biol15: 448–463.
31.
CarterCSPournajafi-NazarlooHKramerKM. (2007) Oxytocin - behavioral associations and potential as a salivary biomarker. Annals of the New York Academy of Sciences1098: 312–322.
32.
CarterCSWilliamsJRWittDM. (1992) Oxytocin and social bonding. Ann NY Acad Sci652: 204–211.
33.
ChangSWCBarterJWEbitzRB. (2012) Inhaled oxytocin amplifies both vicarious reinforcement and self reinforcement in rhesus macaques (Macaca mulatta). Proc Natl Acad Sci U S A109: 959–964.
34.
ClevaRMGassJTWidholmJJ. (2010) Glutamatergic targets for enhancing extinction learning in drug addiction. Curr Neuropharmacol8: 394–408.
35.
CoboE (1973) Effect of different doses of ethanol on the milk-ejecting reflex in lactating women. Am J Obstet Gynecol115: 817–821.
36.
ColeJCSumnallHR (2003) The pre-clinical behavioural pharmacology of 3,4-methylenedioxymethamphetamine (MDMA). Neurosci Biobehav Rev27: 199–217.
37.
CruickshankCCDyerKR (2009) A review of the clinical pharmacology of methamphetamine. Addiction104: 1085–1099.
38.
DaleHH (1906) On some physiological actions of ergot. J Physiol34: 163–206.
39.
DaleHH (1909) The action of extracts of the pituitary body. Biochem J4: 427–447.
40.
DeblonNVeyrat-DurebexCBourgoinL. (2011) Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats. PLoS One6: e25565.
41.
DegenhardtLBrunoRToppL (2010) Is ecstasy a drug of dependence?Drug Alcohol Depend107: 1–10.
42.
DitzenBNaterUMSchaerM. (in press) Sex-specific effects of intranasal oxytocin on autonomic nervous system and emotional responses to couple conflict. Soc Cogn Affect Neurosci.
43.
DonaldsonZRYoungLJ (2008) Oxytocin, Vasopressin, and the neurogenetics of sociality. Science322: 900–904.
44.
DumontGJHSweepFCGJvan der SteenR. (2009) Increased oxytocin concentrations and prosocial feelings in humans after ecstasy (3,4-methylenedioxymethamphetamine) administration. Soc Neurosci4: 359–366.
45.
du VigneaudV (1955) Oxytocin, the principal oxytocic hormone of the posterior pituitar gland: Its isolation, structure, and synthesis. Experientia (Suppl 2): 9–26.
46.
du VigneaudVResslerCSwanJM. (1954) The synthesis of oxytocin. J Am Chem Soc76: 3115–3121.
47.
du VigneaudVResslerCTrippettS (1953) The sequence of amino acids in oxytocin, with a proposal for the structure of oxytocin. J Biol Chem205: 949–957.
48.
DyerRAButwickAJCarvalhoB (2011) Oxytocin for labour and caesarean delivery: Implications for the anaesthesiologist. Curr Opin Anesthesiol24: 255–261.
49.
EagleDMBaunezC (2010) Is there an inhibitory-response-control system in the rat? Evidence from anatomical and pharmacological studies of behavioral inhibition. Neurosci Biobehav Rev34: 50–72.
50.
EckertovaMOndrejcakovaMKrskovaK. (2011) Subchronic treatment of rats with oxytocin results in improved adipocyte differentiation and increased gene expression of factors involved in adipogenesis. Br J Pharmacol162: 452–463.
51.
EngelmannMEbnerKLandgrafR. (1999) Emotional stress triggers intrahypothalamic but not peripheral release of oxytocin in male rats. J Neuroendocrinol11: 867–872.
52.
EngelmannMLandgrafRWotjakCT (2004) The hypothalamic-neurohypophysial system regulates the hypothalamic–pituitary–adrenal axis under stress: An old concept revisited. Front Neuroendocrinol25: 132–149.
53.
EngelmannMWotjakCTNeumannI. (1996) Behavioral consequences of intracerebral vasopressin and oxytocin: Focus on learning and memory. Neurosci Biobehav Rev20: 341–358.
54.
EppersonCNMcDougleCJPriceLH (1996) Intranasal oxytocin in obsessive–compulsive disorder. Biol Psychiatry40: 547–549.
55.
ErmischABarthTRuhleHJ. (1985) On the blood–brain barrier to peptides: Accumulation of labelled vasopressin, DesGlyNH2-vasopressin and oxytocin by brain regions. Endocrinol Exp19: 29–37.
FergusonJKW (1941) A study of the motility of the intact uterus at term. Surg Gynecol Obstet73: 359–366.
60.
FewtrellMSLohKLBlakeA. (2006) Randomised, double blind trial of oxytocin nasal spray in mothers expressing breast milk for preterm infants. Arch Dis Child Fetal Neonatal Ed91: F169–F174.
61.
ForslingMLFallonJKShahD. (2002) The effect of 3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’) and its metabolites on neurohypophysial hormone release from the isolated rat hypothalamus. Br J Pharmacol135: 649–656.
62.
FrancisHHFrancisWJA (1956) Clinial trial of synthetic oxytocin. Br Med J1: 1136–1137.
63.
FuchsARWagnerG (1963) Effect of alcohol on release of oxytocin. Nature198: 92–94.
64.
GershI (1939) The structure and function of the parenchymatous glandular cells in the neurohypophysis of the rat. Am J Anat64: 407–443.
65.
GimplGFahrenholzF (2001) The oxytocin receptor system: Structure, function, and regulation. Physiol Rev81: 629–683.
66.
GingrichBLiuYCascioC. (2000) Dopamine D2 receptors in the nucleus accumbens are important for social attachment in female prairie voles (Microtus ochrogaster). Behav Neurosci114: 173–183.
67.
GoldmanMB (2009) The mechanism of life-threatening water imbalance in schizophrenia and its relationship to the underlying psychiatric illness. Brain Res Rev61: 210–220.
68.
GomoriG (1939) A differential stain for cell types in the pancreatic islets. Am J Pathol15: 497–U437.
69.
GreenLAFeinDModahlC. (2001) Oxytocin and autistic disorder: Alterations in peptide forms. Biol Psychiatry50: 609–613.
70.
GreenARMechanAOElliottJM. (2003) The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”). Pharmacol Rev55: 463–508.
71.
GuastellaAJMacLeodC (2012) A critical review of the influence of oxytocin nasal spray on social cognition in humans: Evidence and future directions. Horm Behav61: 410–418.
72.
GuastellaAJEinfeldSLGrayKM. (2010) Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders. Biol Psychiatry67: 692–694.
73.
GuastellaAJHowardALDaddsMR. (2009) A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder. Psychoneuroendocrinology34: 917–923.
74.
GuastellaAJMitchellPBDaddsMR (2008a) Oxytocin increases gaze to the eye region of human faces. Biol Psychiatry63: 3–5.
75.
GuastellaAJMitchellPBMathewsF (2008b) Oxytocin enhances the encoding of positive social memories in humans. Biol Psychiatry64: 256–258.
76.
GuzekJWSwiderskaZMotylewskaA (1978) The adrenergic influences on the hypothalamic and neurohypophysial oxytocic activity in long-term dehydrated male white rats. Acta Physiol Pol29: 221–230.
77.
HammenC (2005) Stress and depression. Ann Rev Clin Psychol1: 293–319.
78.
HammockEVeenstra-VanderWeeleJYanZ. (2012) Examining autism spectrum disorders by biomarkers: Example from the oxytocin and serotonin systems. J Am Acad Child Adolesc Psychiatry51: 712–721.
79.
HargreavesGAHuntGECornishJL. (2007) High ambient temperature increases 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”)-induced Fos expression in a region-specific manner. Neuroscience145: 764–774.
80.
HeimCYoungLJNewportDJ. (2009) Lower CSF oxytocin concentrations in women with a history of childhood abuse. Mol Psychiatry14: 954–958.
81.
HermensDFLubmanDIWardPB. (2009) Amphetamine psychosis: A model for studying the onset and course of psychosis. Med J Aust190: S22–S25.
82.
HicksCJorgensenWBrownC. (2012) The nonpeptide oxytocin receptor agonist WAY 267,464: Receptor-binding profile, prosocial effects and distribution of c-Fos expression in adolescent rats. J Neuroendocrinol24: 1012–1029.
83.
HollanderEBartzJChaplinW. (2007) Oxytocin increases retention of social cognition in autism. Biol Psychiatry61: 498–503.
84.
HollanderENovotnySHanrattyM. (2003) Oxytocin infusion reduces repetitive behaviors in adults with autistic and Asperger’s disorders. Neuropsychopharmacology28: 193–198.
85.
HuberDVeinantePStoopR (2005) Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Science308: 245–248.
86.
HullEMDominguezJM (2007) Sexual behavior in male rodents. Horm Behav52: 45–55.
87.
HuntGEMcGregorISCornishJL. (2011) MDMA-induced c-Fos expression in oxytocin-containing neurons is blocked by pretreatment with the 5-HT-1A receptor antagonist WAY 100635. Brain Research Bulletin86: 65–73.
88.
HysekCMDomesGLiechtiME (2012) MDMA enhances “mind reading” of positive emotions and impairs “mind reading” of negative emotions. Psychopharmacology222: 293–302.
89.
IvellRRichterD (1984) Structure and comparison of the oxytocin and vasopressin genes from rat. Proc Natl Acad Sci U S A81: 2006–2010.
90.
JarrettTMMcMurrayMSWalkerCH. (2006) Cocaine treatment alters oxytocin receptor binding but not mRNA production in postpartum rat dams. Neuropeptides40: 161–167.
91.
JeromeLSchusterSYazar-KlosinskiBB (in press) Can MDMA play a role in the treatment of substance abuse?Curr Drug Abuse Rev.
92.
JodogneCTirelliEKlingbielP. (1991) Oxytocin attenuates tolerance not only to the hypothermic but also to the myorelaxant and akinesic effects of ethanol in mice. Pharmacol Biochem Behav40: 261–265.
93.
JohnsJMLubinDAWalkerCH. (1997a) Chronic gestational cocaine treatment decreases oxytocin levels in the medial preoptic area, ventral tegmental area and hippocampus in Sprague-Dawley rats. Neuropeptides31: 439–443.
94.
JohnsJMNoonanLRZimmermanLI. (1997b) Effects of short- and long-term withdrawal from gestational cocaine treatment on maternal behavior and aggression in Sprague-Dawley rats. Dev Neurosci19: 368–374.
95.
KalantH (2001) The pharmacology and toxicology of “ecstasy” (MDMA) and related drugs. Can Med Assoc J165: 917–928.
96.
KayeSDarkeSDuflouJ. (2008) Methamphetamine-related fatalities in Australia: Demographics, circumstances, toxicology and major organ pathology. Addiction103: 1353–1360.
97.
KimuraTSajiFNishimoriK. (2003) Molecular regulation of the oxytocin receptor in peripheral organs. J Mol Endocrinol30: 109–115.
98.
KimuraTTanizawaOMoriK. (1992) Structure and expression of a human oxytocin receptor. Nature356: 526–529.
99.
KlavidievaMM (1996) The history of Neuropeptides III. Frontiers in Neuroendocrinology17: 155–179.
100.
KnoblochHSCharletAHoffmannLC. (2012) Evoked axonal oxytocin release in the central amygdala attenuates fear response. Neuron73: 553–566.
101.
KosfeldMHeinrichsMZakPJ. (2005) Oxytocin increases trust in humans. Nature435: 673–676.
102.
KovacsGLHorvathZSarnyaiZ. (1985) Oxytocin and a C-terminal derivative (Z-prolyl-D-leucine) attenuate tolerance to and dependence on morphine and interact with dopaminergic neurotransmission in the mouse brain. Neuropharmacology24: 413–419.
103.
KovacsGLSarnyaiZBabarcziE. (1990) The role of oxytocin–dopamine interactions in cocaine-induced locomotor hyperactivity. Neuropharmacology29: 365–368.
104.
KovacsGLSarnyaiZSzaboG (1998) Oxytocin and addiction: A review. Psychoneuroendocrinology23: 945–962.
105.
KovacsGLVecseiLTelegdyG (1978) Opposite action of oxytocin to vasopressin in passive avoidance behavior in rats. Physiol Behav20: 801–802.
106.
LabuschagneIPhanKLWoodA. (2010) Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder. Neuropsychopharmacology35: 2403–2413.
107.
LabuschagneIPhanKLWoodA. (2011) Medial frontal hyperactivity to sad faces in generalized social anxiety disorder and modulation by oxytocin. Int J Neuropsychopharmacol14: 1–14.
108.
LandgrafRNeumannID (2004) Vasopressin and oxytocin release within the brain: A dynamic concept of multiple and variable modes of neuropeptide communication. Front Neuroendocrinol25: 150–176.
109.
LandgrafRErmischAHessJ (1979) Indications for a brain uptake of labelled vasopressin and ocytocin and the problem of the blood–brain barrier. Endokrinologie73: 77–81.
110.
LeeVHL (1988) Enzymatic barriers to peptide and protein absorption. Crit Rev Ther Drug Carrier Syst5: 69–97.
111.
LeeNKRawsonRA (2008) A systematic review of cognitive and behavioural therapies for methamphetamine dependence. Drug Alcohol Rev27: 309–317.
112.
LeeRFerrisCVan de KarLD. (2009) Cerebrospinal fluid oxytocin, life history of aggression, and personality disorder. Psychoneuroendocrinology34: 1567–1573.
113.
LiCWangWSummerSN. (2008) Molecular mechanisms of antidiuretic effect of oxytocin. J Am Soc Nephrol19: 225–232.
114.
LightKCGrewenKMAmicoJA. (2004) Deficits in plasma oxytocin responses and increased negative affect, stress, and blood pressure in mothers with cocaine exposure during pregnancy. Addict Behav29: 1541–1564.
115.
LischkeABergerCPrehnK. (2012) Intranasal oxytocin enhances emotion recognition from dynamic facial expressions and leaves eye-gaze unaffected. Psychoneuroendocrinology37: 475–481.
116.
LiuYAragonaBJYoungKA. (2010) Nucleus accumbens dopamine mediates amphetamine-induced impairment of social bonding in a monogamous rodent species. Proc Natl Acad Sci U S A107: 1217–1222.
LukasMNeumannI (in press) Oxytocin and vasopressin in rodent behaviors related to social dysfunctions in autism spectrum disorders. Behav Brain Res.
119.
Lutz-BucherBKochB (1980) Evidence for a direct inhibitory effect of morphine on the secretion of posterior pituitary hormones. Eur J Pharmacol66: 375–378.
120.
MacDonaldEDaddsMRBrennanJL. (2011) A review of safety, side-effects and subjective reactions to intranasal oxytocin in human research. Psychoneuroendocrinology36: 1114–1126.
121.
McGrawLAYoungLJ (2010) The prairie vole: An emerging model organism for understanding the social brain. Trends Neurosci33: 103–109.
122.
McGregorISBowenMT (2012) Breaking the loop: Oxytocin as a potential treatment for drug addiction. Horm Behav61: 331–339.
123.
McGregorISCallaghanPDHuntGE (2008) From ultrasocial to antisocial: A role for oxytocin in the acute reinforcing effects and long-term adverse consequences of drug use?Br J Pharmacol154: 358–368.
124.
MackenzieK (1911) An experimental investigation of the mechanism of milk secretion, with special reference to the action of animal extracts. Q J Exper Physiol4: 305–330.
125.
McMurrayMSJoynerPWMiddletonCW. (2008) Intergenerational effects of cocaine on maternal aggressive behavior and brain oxytocin in rat dams. Stress11: 398–410.
126.
ManningMMisickaAOlmaA. (2012) Oxytocin and vasopressin agonists and antagonists as research tools and potential therapeutics. J Neuroendocrinol24: 609–628.
127.
ManningMStoevSChiniB. (2008) Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V(1a), V(1b), V(2) and OT receptors: Research tools and potential therapeutic agents. Progress in Brain Research170: 473–512.
128.
MarshAAYuHHPineDS. (2010) Oxytocin improves specific recognition of positive facial expressions. Psychopharmacology209: 225–232.
129.
MithoeferMWagnerMMithoeferA. (2013) Durability of improvement in post-traumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3,4-methylenedioxymethamphetamineassisted psychotherapy: A prospective longterm follow-up study. J Psychopharmacol27: 28–39.
MoosFFreundmercierMJGuerneY. (1984) Release of oxytocin and vasopressin by magnocellular nuclei in vitro: Specific facilitatory effect of oxytocin on its own release. J Endocrinol102: 63–72.
132.
MorganCJAMuetzelfeldtLMuetzelfeldtM. (2010) Harms associated with psychoactive substances: Findings of the UK National Drug Survey. J Psychopharmacol24: 147–153.
133.
NeumannID (2007) Stimuli and consequences of dendritic release of oxytocin within the brain. Biochem Soc Trans35: 1252–1257.
134.
NeumannIDLandgrafR (2012) Balance of brain oxytocin and vasopressin: Implications for anxiety, depression, and social behaviors. Trends Neurosci35: 649–659.
135.
NeumannIDouglasAJPittmanQJ. (1996) Oxytocin released within the supraoptic nucleus of the rat brain by positive feedback action is involved in parturition-related events. J Neuroendocrinol8: 227–233.
136.
NeumannILudwigMEngelmannM. (1993) Simultaneous microdialysis in blood and brain: Oxytocin and vasopressin release in response to central and peripheral osmotic stimulation and suckling in the rat. Neuroendocrinol58: 637–645.
137.
NickersonKBonsnesRWDouglasRG. (1954) Oxytocin and milk ejection. Am J Obstet Gynecol67: 1028–1034.
138.
NuttDJ (2009) Equasy – an overlooked addiction with implications for the current debate on drug harms. J Psychopharmacol23: 3–5.
139.
OehenPTraberRWidmerV. (2013) Pilot study of MDMA-assisted psychotherapy for treatment-resistant PTSD. J Psychopharmacol27: 40–52.
140.
OhlssonBTruedssonMBengtssonM. (2005) Effects of long-term treatment with oxytocin in chronic constipation; a double blind, placebo-controlled pilot trial. Neurogastroenterol Motil17: 697–704.
141.
OttIScottJC (1910) The action of infundibulum upon mammary secretion. Proc Soc Exper Biol Med8: 48–49.
142.
ParkerKJBuckmasterCLSchatzbergAF. (2005) Intranasal oxytocin administration attenuates the ACTH stress response in monkeys. Psychoneuroendocrinology30: 924–929.
143.
ParkerKJKennaHAZeitzerJM. (2010) Preliminary evidence that plasma oxytocin levels are elevated in major depression. Psychiatry Res178: 359–362.
144.
PedersenCAPrangeAJ (1979) Induction of maternal behavior in virgin rats after intracerebroventricular administration of oxytocin. Proc Natl Acad Sci U S A76: 6661–6665.
PedersenCAGibsonCMRauSW. (2011) Intranasal oxytocin reduces psychotic symptoms and improves Theory of Mind and social perception in schizophrenia. Schizophr Res132: 50–53.
147.
PedersenCASmedleyKLLesermanJ. (in press) Intranasal oxytocin blocks alcohol withdrawal in human subjects. Alcohol Clin Exp Res.
148.
QiJHanWYYangJY. (2012) Oxytocin regulates changes of extracellular glutamate and GABA levels induced by methamphetamine in the mouse brain. Addict Biol17: 758–769.
149.
QiJYangJYSongM. (2008) Inhibition by oxytocin of methamphetamine-induced hyperactivity related to dopamine turnover in the mesolimbic region in mice. Naunyn Schmiedebergs Arch Pharmacol376: 441–448.
150.
QiJYangJYWangF. (2009) Effects of oxytocin on methamphetamine-induced conditioned place preference and the possible role of glutamatergic neurotransmission in the medial prefrontal cortex of mice in reinstatement. Neuropharmacology56: 856–865.
151.
QuirinMKuhlJDuesingR (2011) Oxytocin buffers cortisol responses to stress in individuals with impaired emotion regulation abilities. Psychoneuroendocrinology36: 898–904.
152.
RimmeleUHedigerKHeinrichsM. (2009) Oxytocin makes a face in memory familiar. J Neurosci29: 38–42.
153.
RingRHSchechterLELeonardSK. (2010) Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist. Neuropharmacology58: 69–77.
154.
RodriguezEMBlazquezJLGuerraM (2010) The design of barriers in the hypothalamus allows the median eminence and the arcuate nucleus to enjoy private milieus: The former opens to the portal blood and the latter to the cerebrospinal fluid. Peptides31: 757–776.
155.
RoseMEGrantJE (2008) Pharmacotherapy for methamphetamine dependence: A review of the pathophysiology of methamphetamine addiction and the theoretical basis and efficacy of pharmacotherapeutic interventions. Ann Clin Psychiatry20: 145–155.
RuisHRollandRDoesburgW. (1981) Oxytocin enhances onset of lactation among mothers delivering prematurely. Br Med J283: 340–342.
158.
SarnyaiZ (1993) Measurement of cocaine-induced stereotyped behavior in response to neuropeptides. In: ConnP.M. (ed) Methods in Neuroscience, Vol 14, Paradigms for the Study of Behavior. San Diego: Academic Press, pp. 153–165.
159.
SarnyaiZ (1998) Oxytocin and neuroadaptation to cocaine. Prog Brain Res119: 449–466.
160.
SarnyaiZKovacsGL (1994) Role of oxytocin in the neuroadaptation to drugs of abuse. Psychoneuroendocrinology19: 85–117.
161.
SarnyaiZBabarczyEKrivanM. (1991) Selective attenuation of cocaine-induced stereotyped behaviour by oxytocin: Putative role of basal forebrain target sites. Neuropeptides19: 51–56.
162.
SarnyaiZBiroEBabarczyE. (1992) Oxytocin modulates behavioral adaptation to repeated treatment with cocaine in rats. Neuropharmacology31: 593–598.
163.
SarnyaiZSzaboGKovacsGL. (1990) Oxytocin attenuates the cocaine-induced exploratory hyperactivity in mice. Neuroreport1: 200–202.
164.
SasayamaDHattoriKTeraishiT. (2012) Negative correlation between cerebrospinal fluid oxytocin levels and negative symptoms of male patients with schizophrenia. Schizophr Res139: 201–206.
165.
ScantamburloGHansenneMFuchsS. (2007) Plasma oxytocin levels and anxiety in patients with major depression. Psychoneuroendocrinology32: 407–410.
166.
SchaferEA (1913) On the effect of pituitary and corpus luteum extracts on the mammary gland in the human subject. Q J Exp Physiol6: 17–19.
167.
SchaferEAMackenzieK (1911) The action of animal extracts on milk secretion. Proc R Soc Lond Series B84: 16–22.
168.
ScharrerEScharrerB (1937) Über drüsen-nervenzellen und neurosekretorische organe be1 wirbellosen und wirbeltieren. Biol Rev12: 185–216.
169.
SchulzHKovacsGLTelegdyG (1979) Action of posterior pituitary neuropeptides on the nigrostriatal dopaminergic system. Eur J Pharmacol57: 185–190.
170.
SessaB (2007) Is there a case for MDMA-assisted psychotherapy in the UK?J Psychopharmacol21: 220–224.
171.
SkuseDHGallagherL (2009) Dopaminergic-neuropeptide interactions in the social brain. Trends Cogn Sci13: 27–35.
172.
SofroniewMV (1980) Projections from vasopressin, oxytocin, and neurophysin neurons to neural targets in the rat and human. J Histochem Cytochem28: 475–478.
173.
SofroniewMV (1983) Morphology of vasopressin and oxytocin neurones and their central and vascular projections. Prog Brain Res60: 101–114.
174.
SofroniewMVWeindlASchrellU. (1981) Immunohistochemistry of vasopressin, oxytocin and neurophysin in the hypothalamus and extrahypothalamic regions of the human and primate brain. Acta Histochem Suppl24: 79–95.
SulzerDSondersMSPoulsenNW. (2005) Mechanisms of neurotransmitter release by amphetamines: A review. Prog Neurobiol75: 406–433.
177.
SzaboGKovacsGLTelegdyG (1987) Neurohypophyseal peptides and ethanol tolerance and dependence. Front Horm Res15: 128–137.
178.
SzaboGKovacsGLTelegdyG (1989) Intraventricular administration of neurohypophyseal hormones interferes with the development of tolerance to ethanol. Acta Physiol Hung73: 97–103.
179.
SzetoAMcCabePMNationDA. (2011) Evaluation of enzyme immunoassay and radioimmunoassay methods for the measurement of plasma oxytocin. Psychosom Med73: 393–400.
180.
TamashiroKLSakaiRRShivelyCA. (2011) Chronic stress, metabolism, and metabolic syndrome. Stress14: 468–474.
181.
TammaRColaianniGZhuL-l. (2009) Oxytocin is an anabolic bone hormone. Proc Natl Acad Sci U Sf A106: 7149–7154.
182.
TheodosisDTTrailinAPoulainDA (2006) Remodeling of astrocytes, a prerequisite for synapse turnover in the adult brain? Insights from the oxytocin system of the hypothalamus. Am J Physiol Regul Integr Comp Physiol290: R1175–R1182.
183.
ThompsonMRCallaghanPDHuntGE. (2007) A role for oxytocin and 5-HT1A receptors in the prosocial effects of 3,4-methylenedioxymethamphetamine ("ecstasy"). Neuroscience146: 509–514.
184.
UhlGRHallFSSoraI (2002) Cocaine, reward, movement and monoamine transporters. Mol Psychiatry7: 21–26.
185.
Uvnäs-MobergKAhleniusSHillegaartV. (1994) High doses of oxytocin cause sedation and low doses cause an anxiolytic-like effect in male rats. Pharmacol Biochem Behav49: 101–106.
186.
VaccariCLolaitSJOstrowskiNL (1998) Comparative distribution of vasopressin V1b and oxytocin receptor messenger ribonucleic acids in brain. Endocrinology139: 5015–5033.
187.
Van IjzendoornMHBakermans-KranenburgMJ (2012) A sniff of trust: Meta-analysis of the effects of intranasal oxytocin administration on face recognition, trust to in-group, and trust to out-group. Psychoneuroendocrinology37: 438–443.
188.
van NieuwenhuijzenPSLongLEHuntGE. (2010) Residual social, memory and oxytocin-related changes in rats following repeated exposure to gamma-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination. Psychopharmacology212: 663–674.
189.
VieroCShibuyaIKitamuraN. (2010) Oxytocin: Crossing the bridge between basic science and pharmacotherapy. CNS Neurosci Ther16: e138–e156.
190.
VivianiDStoopR (2008) Opposite effects of oxytocin and vasopressin on the emotional expression of the fear response. Progress in Brain Research170: 207–218.
191.
VivianiDTerrettazTMagaraF. (2010) Oxytocin enhances the inhibitory effects of diazepam in the rat central medial amygdala. Neuropharmacology58: 62–68.
192.
WilliamsJRCarterCSInselT (1992) Partner preference development in female prairie voles is facilitated by mating or the central infusion of oxytocin. Ann NY Acad Sci652: 487–489.
193.
WilliamsJRInselTRHarbaughCR. (1994) Oxytocin administered centrally facilitates formation of a partner preference in female prairie voles (Microtus ochrogaster). J Neuroendocrinol6: 247–250.
194.
WittDMCarterCSWaltonDM (1990) Central and peripheral effects of oxytocin administration in prairie voles (Microtus ochrogaster). Pharmacol Biochem Behav37: 63–69.
195.
WittDMWinslowJTInselTR (1992) Enhanced social interactions in rats following chronic, centrally infused oxytocin. Pharmacol Biochem Behav43: 855–861.
196.
WolffKTsapakisEMWinstockAR. (2006) Vasopressin and oxytocin secretion in response to the consumption of ecstasy in a clubbing population. J Psychopharmacol20: 400–410.
197.
WotjakCTGansterJKohlG. (1998) Dissociated central and peripheral release of vasopressin, but not oxytocin, in response to repeated swim stress: New insights into the secretory capacities of peptidergic neurons. Neuroscience85: 1209–1222.
198.
YoshimuraRKiyamaHKimuraT. (1993) Localization of oxytocin receptor messenger ribonucleic acid in the rat brain. Endocrinology133: 1239–1246.
199.
YoungWSGainerH (2003) Transgenesis and the study of expression, cellular targeting and function of oxytocin, vasopressin and their receptors. Neuroendocrinology78: 185–203.
200.
YoungLJLimMMGingrichB. (2001) Cellular mechanisms of social attachment. Horm Behav40: 133–138.
201.
ZahniserNRSorkinA (2009) Trafficking of dopamine transporters in psychostimulant actions. Semin Cell Dev Biol20: 411–417.
202.
ZhangGZhangYFastDM. (2011) Ultra sensitive quantitation of endogenous oxytocin in rat and human plasma using a two-dimensional liquid chromatography-tandem mass spectrometry assay. Anal Biochem416: 45–52.
203.
ZhuJHJiangYJXuGL. (2012) Intranasal administration: a potential solution for cross-BBB delivering neurotrophic factors. Histol Histopathol27: 537–548.
