Female hooded-Lister rats received either subchronic phencyclidine (PCP) (2 mg/kg, n = 20) or vehicle (1 ml/kg, n = 20) intraperitoneally twice daily for 7 days, followed by a 7-day washout period. Rats were challenged with acute PCP or vehicle and tested for locomotor activity to ensure hyperactivity was observed in the subchronic PCP-treated rats. Rats were then tested on the elevated plus maze and in an open field for 10 min. Subchronic PCP did not significantly affect behaviour on the elevated plus maze or in the open field. In conclusion, subchronic PCP does not induce anxiety-like behaviour.
Abdul-Monim, Z., Reynolds, GP, Neill, JC ( 2006) The effect of atypical and classical antipsychotics on sub-chronic PCP-induced cognitive deficits in a reversal-learning paradigm . Behav Brain Res169: 263-273.
2.
Abdul-Monim, Z., Reynolds, GP, Neill, JC ( 2007) Sub-chronic psychotomimetic phencyclidine induces deficits in reversal learning and alteration in parvalbumin-immunoreactive expression in the rat. J Psychopharmacol21: 198-205.
3.
Abekawa, T., Ito, K., Nakagawa, S., Koyama, T. ( 2007) Prenatal exposure to an NMDA receptor antagonist, MK-801 reduces density of parvalbumin-immunoreactive GABAergic neurons in the medial prefrontal cortex and enhances phencyclidine-induced hyperlocomotion but not behavioral sensitization to methamphetamine in postpubertal rats. Psychopharmacology192: 303-316.
4.
Audet, M-C., Goulet, S., Doré, FY ( 2007) Enhanced anxiety follows withdrawal from subchronic exposure to phencyclidine in rats. Behav Brain Res176: 358-361.
5.
Becker, A., Grecksch, G. ( 1996) Illumination has no effect on rats’ behavior in the elevated plus-maze. Physiol Behav59: 1175-1177.
6.
Bowman, RE, MacLusky, NJ, Sarmiento, Y., Frankfurt, M., Gordon, M., Luine, VN ( 2004) Sexually dimorphic effects of prenatal stress on cognition, hormonal responses, and central neurotransmitters. Endocrinology145: 3778-3787.
7.
Cochran, SM, Kennedy, M., McKerchar, CE, Steward, LJ, Pratt, JA, Morris, BJ ( 2003) Induction of metabolic hypofunction and neuro-chemical deficits after chronic intermittent exposure to phencyclidine: differential modulation by antipsychotic drugs. Neuropsychopharmacology28: 265-275.
8.
Cole, BJ, Hillmann, M., Seidelmann, D., Klewer, M., Jones, GH ( 1995) Effects of benzodiazepine receptor partial inverse agonists in the elevated plus maze test of anxiety in the rat. Psychopharmacology121: 118-126.
9.
du Bois, TM, Huang, X-F., Deng, C. ( 2008) Perinatal administration of PCP alters adult behaviour in female Sprague-Dawley rats. Behav Brain Res188: 416-419.
10.
Gentsch, C., Lichtsteiner, M., Feer, H. ( 1987) Open field and elevated plus maze: a behavioural comparison between spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats and the effects of chlordiazepoxide. Behav Brain Res25: 101-107.
11.
Gray, JA ( 1979) Emotionality in male and female rodents: a reply to Archer . Br J Psychol70: 425-440.
12.
Grayson, B., Idris, NF, Neill, JC ( 2007) Atypical antipsychotics attenuate a sub-chronic PCP-induced cognitive deficit in the NOR task in the rat. Behav Brain Res184: 31-38.
13.
Hall, FS, Huang, S., Fong, GW, Sundstrom, JM, Pert, A. ( 2000) Differential basis of strain and rearing effects on open-field behaviour in Fawn Hooded and Wistar rats. Physiol Behav71: 525-532.
14.
Javitt, DC, Zukin, SR ( 1991) Recent advances in the phencyclidine model of schizophrenia . Am J Psychiatry148: 1301-1308.
15.
Jentsch, JD, Roth, RH ( 1999) The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia. Neuropsychopharmacology20: 201- 225.
16.
Johnston, AL, File, SE ( 1991) Sex differences in animal tests of anxiety. Physiol Behav49: 245-250.
17.
Kalinichev, M., Robbins, MJ, Hartfield, EM, Maycox, PR, Moore, SH, Savage, KM, et al. (2008) Comparison between intraperitoneal and subcutaneous phencyclidine administration in Sprague-Dawley rats: a locomotor activity and gene induction study. Prog Neuropsychopharmacol Biol Psychiatry32: 414-422.
18.
McLean, SL, Beck, JP, Woolley, ML, Neill, JC ( 2008) A preliminary investigation into the effects of antipsychotics on sub-chronic phencyclidine-induced deficits in attentional set-shifting in female rats. Behav Brain Res189: 152-158.
19.
Olney, JW, Newcomer, JW, Farber, NB ( 1999) NMDA receptor hypofunction model of schizophrenia. J Psychiatr Res33: 523-533.
20.
Pellow, S., Chopin, P., File, SE, Briley, M. ( 1985) Validation of open, closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods14: 149-167.
21.
Rex, A., Voigt, J-P., Gustedt, C., Beckett, S., Fink, H. ( 2004) Anxiolyticlike profile in Wistar, but not Sprague-Dawley rats in the social interaction test. Psychopharmacology177: 23-34.
22.
Reynolds, LM, Cochran, SM, Morris, BJ, Pratt, JA, Reynolds, GP ( 2005) Chronic phencyclidine administration induces schizophrenia-like changes in N-acetylaspartate and N-acetylaspartylglutamate in rat brain. Schizophr Res73: 147-152.
23.
Rodefer, JS, Murphy, ER, Baxter, MG ( 2005) PDE10A inhibition reverses subchronic PCP-induced deficits in attentional set-shifting in rats. Eur J Neurosci21: 1070-1076.
24.
Rodgers, RJ, Cole, JC ( 1993) Anxiety enhancement in the murine elevated plus maze by immediate prior exposure to social stressors. Physiol Behav53: 383-388.
25.
Schwabe, K., Klein, S., Koch, M. ( 2006) Behavioural effects of neonatal lesions of the medial prefrontal cortex and sub-chronic pubertal treatment with phencyclidine of adult rats. Behav Brain Res168: 150-160.
26.
Snigdha, S., Neill, J., Shahid, M., Cruise, L., Henry, B. ( 2007) Brain-derived neurotrophic factor downregulation in rat brain following sub-chronic phencyclidine administration. Eur Neuropsychopharmacol17 (Suppl. 4): S258.
27.
Snigdha, S., Neill, JC ( 2008) Efficacy of antipsychotics to reverse phencyclidine-induced social interaction deficits in female rats - a preliminary investigation. Behav Brain Res187: 489-494.
28.
Sutcliffe, JS, Marshall, KM, Neill, JC ( 2007) Influence of gender on working and spatial memory in the novel object recognition task in the rat. Behav Brain Res177: 117-125.
29.
Toufexis, DJ, Myers, KM, Davis, M. ( 2006) The effect of gonadal hormones and gender on anxiety and emotional learning. Horm Behav50: 539-549.
30.
Walsh, RN, Cummins, RA ( 1976) The open field test: a critical review. Psychol Bull83: 481-504.
31.
Yonezawa, Y., Kuroki, T., Kawahara, T., Tashiro, N., Uchimura, H. ( 1998) Involvement of γ-aminobutyric acid neurotransmission in phencyclidine-induced dopamine release in the medial prefrontal cortex . Eur J Pharmacol341: 45-56.
