MDMA as a clinical tool: a note of caution. A response to Sessa and Nutt

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Bull, EJ , Hutson, PH , Fone, KCF (2004) Decreased social behaviour following 3,4-methylenedioxymethamphetamine (MDMA) is accompanied by changes in 5-HT2A receptor responsivity. Neuro-pharmacology 46: 202-210.

Chance, MRA (1946) Aggregation as a factor influencing the toxicity of sympathomimetic amines in mice. J Pharmacol Exp Ther 87: 214-219.

Chance, MRA (1947) Factors influencing the toxicity of sympathomimetic amines to solitary mice. J Pharmacol Exp Ther 89: 289-296.

Colado, MI , O'Shea, E. , Green, AR (2004) Acute and long-term effects of MDMA on cerebral dopamine biochemistry and function. Psychopharmacology 173: 249-263.

Colado, MI , O'Shea, E. , Granados, R. , Esteban, B. , Martin, AB , Green, AR (1999) Studies on the role of dopamine in the degeneration of rat brain 5-HT following administration of 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy"). Br J Pharmacol 126: 911-924.

Costain, DW , Green, AR , Grahame-Smith, DG (1979) Enhanced 5-hydroxytryptamine mediated behavioural responses in rats following repeated electroconvulsive shock: relevance to the mechanism of the antidepressive effect of electroconvulsive therapy. Psychopharmacology 11: 167-170.

Esteban, B. , O'Shea, E. , Camarero, J. , Sanchez, V. , Green, AR , Colado, MI (2001) 3,4-Methylenedioxymethamphetamine induces monoamine release, but not toxicity, when administered centrally at a concentration occurring following a peripherally injected neurotoxic dose. Psychopharmacology 154: 251-260.

Evans, JPM , Grahame-Smith, DG , Green, AR , Tordoff, AFC (1976) Electroconvulsive shock increases the behavioural responses of rats to brain 5-hydroxytryptamine accumulation and central nervous system stimulant drugs. Br J Pharmacol 56: 193-199.

Fantegrossi, WE , Godlewski, T. , Karabenick, RL , Stephens, JM , Ullrich, T. , Rice, KC , et al. (2003) Pharmacological characterization of the effects of 3,4-methylenedioxymethamphetamine ("ecstasy") and its enantiomers on lethality, core temperature, and locomotor activity in singly housed and crowded mice. Psychopharmacology 166: 202-211.

10.

Gough, B. , Ali, SF , Slikker, W. , Holson, RR (1991) Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate. Pharmacol Biochem Behav 38: 339-344.

11.

Grahame-Smith, DG (1967) The biosynthesis of 5-hydroxytryptamine in brain . Biochem J 105: 351-360.

12.

Green, AR (2004) MDMA: fact and fallacy, and the need to increase knowledge in both the scientific and popular press. Psychopharmacology 173: 231-233.

13.

Green, AR , Heal, DJ , Grahame-Smith, DG (1977) Further observations on the effect of repeated electro-convulsive shock on the behavioural responses of rats produced by increases in the functional activity of brain 5-hydroxytryptamine and dopamine . Psychopharmacology 52: 195-200.

14.

Green, AR , Nutt, DJ (1987) Psychopharmacology of electroconvulsive therapy . Handbook of Psychopharmacology 19: 375-420 (Eds: Iversen, LL, Iversen, SD & Snyder, SH) Plenum Press, New York.

15.

Green, AR , Mechan, AO , Elliott, JM , O'Shea, E. , Colado, MI (2003) The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy"). Pharmacol Rev 55: 463-508.

16.

Gunn, JA , Gurd, MR (1940) The action of some amines related to adrenaline. Cyclohexylalkylamines. J Physiol (Lond ) 97: 453-470.

17.

Jones, DC , Duvauchelle, C. , Ikegami, A. , Olsen, CM , Lau, SS , Torre, R de la , et al. (2005) Serotonergic neurotoxic metabolites of ecstasy identified in rat brain. J Pharmacol Exp Ther 313: 422-431.

18.

Koch, S. , Galloway, MP (1997) MDMA-induced dopamine release in vivo: role of endogenous serotonin. J Neural Transm 104: 135-146.

19.

Liechti, ME , Vollenweider, FX (2001) Which neuroreceptors mediate the subjective effects of MDMA in humans? A summary of the mechanistic studies. Hum Psychopharmacol 16: 589-598.

20.

Lew, R. , Sabol, KE , Chou, C. , Vosmer, GL , Richards, JB , Seiden, LS (1996) Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52 week period. Part II: radioligand binding and autoradiography studiessynaptosomal uptake and tissue concentrations. J Pharmacol Exp Ther 276: 855-865.

21.

Malberg, JE , Seiden, LS (1998) Small changes in ambient temperature cause large changes in 3,4-methylenedioxymethamphetamine (MDMA)-induced serotonin neurotoxicity and core body temperature in the rat. J Neurosci 18: 5086-5094.

22.

McGregor, IS , Clemens, KJ , Van der Plasse, G. , Li, KM , Hunt, GE , Chen, F. , et al. (2003) Increased anxiety 3 months after brief exposure to MDMA ('Ecstasy') in rats: Association with altered 5-HT transporter and receptor density. Neuropsychopharmacology 28: 1472-1484.

23.

Mechan, AO , Esteban, B. , O'Shea, E. , Elliott, JM , Green, AR (2002) The pharmacology of the acute hyperthermic response that follows administration of 3,4-methylenedioxymethamphetamine (MDMA, `ecstasy') to rats. Br J Pharmacol 135: 170-180.

24.

Modigh, K. (1975) Electroconvulsive shock and post-synaptic catecholamine effects: increased psychomotor stimulant action of apomorphine and clonidine in reserpine-treated mice by repeated ECS. J Neural Transm 36: 19-32.

25.

Nutt, D. , Demyttenaere, K. , Janka, Z. , Aarre, T. , Bourin, M. , Canonico, PL , et al. (2007) The other face of depression, reduced positive affect: the role of catecholamines in causation and cure. J Psychopharmacol 21: 461-471.

26.

Sabol, KE , Lew, R. , Richards, JB , Vosmer, GL , Seiden, LS (1996) Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52 week period. Part I: synaptosomal uptake and tissue concentrations. J Pharmacol Exp Ther 276: 846-854.

27.

O'Shea, E. , Escobedo, I. , Orio, L. , Sanchez, V. , Navarro, M. , Green, AR , et al. (2005) Elevation of ambient room temperature has differential effects on MDMA-induced 5-HT and dopamine release in striatum and nucleus accumbens of rats. Neuropsychopharmacology 30: 1312-1323.

28.

O'Shea, E. , Granados, R. , Estaban, B. , Colado, MI , Green, AR (1998) The relationship between the degree of neurodegeneration of rat brain 5-HT terminals and the dose and frequency of administration of MDMA ("ecstasy"). Psychopharmacology 37: 919-926.

29.

O'Shea, E. , Orio, L. , Escobedo, I. , Sanchez, V. , Camarero, J. , Green, AR , et al. (2006) MDMA-induced neurotoxicity: long-term effects on 5-HT biosynthesis and the influence of ambient temperature. Br J Pharmacol 148: 778-785.

30.

Parrott, AC (2007) The psychotherapeutic potential of MDMA (3,4-methylenedioxymethamphetamine): an evidence-based review. Psychopharmacology 191: 181-193.

31.

Sanchez, V. , Camarero, J. , Esteban, B. , Peter, MJ , Green, AR , Colado, MI (2001) The mechanisms involved in the long-lasting neuroprotective effect of fluoxetine against MDMA (`ecstasy')-induced degeneration of 5-HT nerve endings in rat brain. Br J Pharmacol 134: 46-57.

32.

Sessa, B. , Nutt, DJ (2007) MDMA, politics and medical research: have we thrown the baby out with the bathwater?. J Psychopharmacol 21: 787-791.

33.

White, SR , Duffy, P. , Kalivas, PW (1994) Methylenedioxymethamphetamine depresses glutamate-evoked neuronal firing and increases extracellular dopamine and serotonin in the nucleus accumbens in vivo. Neuroscience 62: 41-50.