Little is known about the use of antipsychotics in pregnancy and the corresponding plasma levels in the newborn child. We report on a woman with schizophrenia treated with olanzapine during pregnancy. Plasma levels of olanzapine were assessed both from the mother and from umbilical cord. The plasma level of the newborn (11 ng/mL) was about one third compared to the mother (range 25—34 ng/mL).The development of the fetus, delivery and the development of the child during the first six months were normal.
Barnas C., Bergant A., Hummer M., Saria A., Fleischhacker W.W. (1994) Clozapine concentrations in maternal and fetal plasma, amniotic-fluid, and breast-milk. Am J Psychiatry151: 945
2.
Kirchheiner J., Berghofer A., Bolk-Weischedel D. (2000) Healthy outcome under olanzapine treatment in a pregnant woman. Pharmacopsychiatry33: 78-80
3.
Kirk L., Jorgensen A. (1980) Concentrations of Cis(Z)-flupentixol in maternal serum, amniotic fluid, umbilical cord serum, and milk. Psychopharmacology (Berl) 72: 107-108
