Evidence-based guidelines for management of attention-deficit/hyperactivity disorder in adolescents in transition to adult services and in adults: recommendations from the British Association for Psychopharmacology
Restricted accessResearch articleFirst published online January, 2007
Evidence-based guidelines for management of attention-deficit/hyperactivity disorder in adolescents in transition to adult services and in adults: recommendations from the British Association for Psychopharmacology
Attention-deficit/hyperactivity disorder (ADHD) is an established diagnosis in children, associated with a large body of evidence on the benefits of treatment. Adolescents with ADHD are now leaving children’s services often with no readily identifiable adult service to support them, which presents problems as local pharmacy regulations often preclude the prescription of stimulant drugs by general practitioners (GPs). In addition, adults with ADHD symptoms are now starting to present to primary care and psychiatry services requesting assessment and treatment. For these reasons, the British Association for Psychopharmacology (BAP) thought it timely to hold a consensus conference to review the body of evidence on childhood ADHD and the growing literature on ADHD in older age groups. Much of this initial guidance on managing ADHD in adolescents in transition and in adults is based on expert opinion derived from childhood evidence. We hope that, by the time these guidelines are updated, much evidence will be available to address the many directions for future research that are detailed here.
Adler L A, Kessler R C, Spencer T (2004) Adult ADHD Self-Report Scale-v 1.1 (ASRS-v1.1) Symptom Checklist. New York, NY. Available at: www.med.nyu.edu/psych/assets/adhdscreen18.pdf
2.
Adler L A , Resnick S , Kunz M , Devinsky O (1995) Open-label trial of venlafaxine in adults with attention deficit disorder . Psychopharmacol Bull31: 785-788
3.
Adler L A , Spencer T J , Milton D R , Moore R J , Michelson D (2005a) Long-term, open-label study of the safety and efficacy of atomoxetine in adults with attention-deficit/hyperactivity disorder: an interim analysis . J Clin Psychiatry66: 294-299
4.
Adler L A , Spencer T , Faraone S V , Reimherr F W , Kelsey D , Michelson D , Biederman J (2005b) Training raters to assess adult ADHD: reliability of ratings . J Atten Disord8: 121-126
5.
Allen A J , Kurlan R M , Gilbert D L , Coffey B J , Linder S L , Lewis D W , Winner P K , Dunn D W , Dure L S , Sallee F R , Milton D R , Mintz M I , Ricardi R K , Erenberg G , Layton L L , Feldman P D , Kelsey D K , Spencer T J (2005) Atomoxetine treatment in children and adolescents with ADHD and comorbid tic disorders . Neurology65: 1941-1949
6.
Alsop M (2005) Equality in Justice, ADHD Across the Lifespan. Dorset ADHD Support Group, Weymouth (www.dorsetadhd.org.uk)
7.
Aman M G , Buican B , Arnold L E (2003) Methylphenidate treatment in children with borderline IQ and mental retardation: analysis of three aggregated studies . J Child Adolesc Psychopharmacology13: 29-40
8.
Aman M G , Smedt G D , Derivan A , Lyons B , Findling R L (2002) Double-blind, placebo-controlled study of risperidone for the treatment of disruptive behaviours in children with subaverage intelligence . Am J Psychiatry159: 1337-1346
9.
American Association on Mental Retardation , Rush A J , Frances A (2000) Expert Consensus Guidelines Series: Treatment of psychiatric and behavioral problems in mental retardation . Am J Mental Retardation105: 178-188
10.
American Psychiatric Association (2000) Diagnostic and Statistical Manual of Mental Disorders version IV text revision. American Psychiatric Association, Washington DC
11.
Andersen P H (1989) The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action . Eur J Pharmacol166: 493-504
12.
Anderson I M , Nutt D J , Deakin J F (2000) Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 1993 British Association for Psychopharmacology guidelines. British Association for Psychopharmacology . J Psychopharmacol14: 3-20
13.
Arcos-Burgos M , Castellanos F X , Pineda D , Lopera F , Palacio J D , Palacio L G , Rapoport J L , Berg K , Bailey-Wilson J E , Muenke M (2004) Attention-deficit/hyperactivity disorder in a population isolate: linkage to loci at 4q13.2, 5q33.3, 11q22, and 17p11 . Am J Hum Genet75: 998-1014
14.
Arnold L E , Kleykamp D , Votolato N A , Taylor W A , Kontras S B , Tobin K (1989) Gamma-linolenic acid for attention-deficit hyperactivity disorder: placebo-controlled comparison to D-amphetamine . Biol Psychiatry25: 222-228
15.
Asherson P (2005) Clinical assessment and treatment of attention deficit hyperactivity disorder in adults . Expert Rev Neurotherapeutics5: 525-539
16.
Asherson P , Kuntsi J , Taylor E (2005) Unravelling the complexity of attention-deficit hyperactivity disorder: a behavioural genomic approach . Brit J Psychiatry187: 103-105
17.
Ashton C H , Gallagher P , Moore B (2006) The adult psychiatrist’s dilemma: psychostimulant use in attention deficit/hyperactivity disorder . J Psychopharmacol20: 602-610
18.
Avery R A , Franowicz J S , Studholme C , van Dyck C H , Amsten A F (2000) The alpha-2A-adrenoceptor agonist, guanfacine, increases regional cerebral blood flow in dorsolateral prefrontal cortex of monkeys performing a spatial working memory task . Neuropsychopharmacology23: 240-249
19.
Bakker S C , van der Meulen E M , Buitelaar J K , Sandkuijl L A , Pauls D L , Monsuur A J , van’t Slot R , Minderaa R B , Gunning W B , Pearson P L , Sinke R J (2003) A whole-genome scan in 164 Dutch sib pairs with attention-deficit/hyperactivity disorder: suggestive evidence for linkage on chromosomes 7p and 15q . Am J Hum Genet72: 1251-1260
20.
Baldwin D S , Anderson I M , Nutt D J , Bandelow B , Bond A , Davidson J R T , den Boer J A , Fineberg N A , Knapp M , Scott J , Wittchen H-U (2005) Evidence-based guidelines for the pharmacological treatment of anxiety disorders: recommendations from the British Association of Psychopharmacology . J Psychopharm19: 567-596
21.
Bambinski L M , Hartsough C S , Lambert N M (1999) Childhood conduct problems, hyperactivity-impulsivity, and inattention as predictors of adult criminal activity . J Child Psychol Psychiatry40: 347-355
22.
Banaschewski T , Coghill D , Santosh P , Zuddas A , Asherson P , Buitelaar J , Danckaerts M , Dopfner M , Faraone S V , Rothenberger A , Sergeant J , Steinhausen H-C , Sonuga-Barke E J S , Taylor E (2006) Long-acting medications for the hyperkinetic disorders -a systematic review and European treatment guidelineEur Child Adolesc Psychiatry [Epub ahead of print, May]
23.
Barkley R A (2002) Major life activity and health outcomes associated with attention-deficit/hyperactivity disorder . J Clin Psychiatry63 (suppl. 12): 10-15
24.
Barkley R A (2006) Attention Deficit Hyperactivity Disorder: A Handbook for Diagnosis and Treatment, 3rd edn.Guilford Press, New York
25.
Barkley R A , Murphy K (2006) Attention Deficit Hyperactivity Disorder: A Clinical Workbook, 3rd edn.Guilford Press, New York
26.
Barkley R A , Grodzinsky G , DuPaul G J (1992) Frontal lobe functions in attention deficit disorder with and without hyperactivity: a review and research report . J Abnorm Child Psychol20: 163-188
27.
Barkley R A , Fischer M , Edelbrock C S , Smallish L (1990) The adolescent outcome of hyperactive children diagnosed by research criteria: I. An 8-year prospective follow-up study . J Am Acad Child Adolesc Psychiatry29: 546-557
28.
Berlin L , Bohlin G , Nyberg L , Janols L O (2004) How well do measures of inhibition and other executive functions discriminate between children with ADHD and controls?Neuropsychol Dev Cogn C Child Neuropsychol10: 1-13
29.
Biederman J , Mick E , Faraone S V (1998) Normalized functioning in youths with persistent attention-deficity/hyperactivity disorder . J Pediatr Oct133(4): 544-551
30.
Biederman J (2004) Impact of comorbidity in adults with attention-deficit/hyperactivity disorder . J Clin Psychiatry65 (suppl. 3): 3-7
Biederman J , Spencer T J (2001) Psychopharmacology of adults with attention-deficit/hyperactivity disorder . Primary Psychiatry11: 57-62
33.
Biederman J , Mick E , Faraone S V (2000) Age-dependent decline of symptoms of attention deficit hyperactivity disorder: impact of remission definition and symptom type . Am J Psychiatry157: 816-818
34.
Biederman J , Spencer T J , Wilens T E , Weisler R H , Read S C , Rulloch S J , SLI381.304 study group (2005) Long-term safety and effectiveness of mixed amphetamine salts extended release in adults with ADHD . CNS Spectr10 (suppl. 20): 16-25
35.
Biederman J , Faraone S V , Milberger S , Jetton J G , Chen L , Mick E , Greene R W , Russell R L (1996a) Is childhood oppositional defiant disorder a precursor to adolescent conduct disorder? Findings from a four-year follow-up study of children with ADHD . J Am Acad Child Adolesc Psychiatry35: 1193-1204
36.
Biederman J , Faraone S , Milberger S , Guite J , Mick E , Chen L , Mennin D , Marrs A , Ouellette C , Moore P , Spencer T , Norman D , Wilens T , Kraus I , Perrin J (1996b) A prospective 4-year follow-up study of attention-deficit hyperactivity and related disorders . Arch Gen Psychiatry53: 437-446
37.
Bloom B , Dey A N (2004) Summary health statistics for U.S. children: National Health Interview Survey . Vital Health Stat10: 1-85
38.
Boris M , Mandel F S (1994) Foods and additives are common causes of the attention deficit hyperactive disorder in children . Ann Allergy72: 462-468
39.
Brandon C L , Marinelli M , Baker L K , White F J (2001) Enhanced reactivity and vulnerability to cocaine following methylphenidate treatment in adolescent rats . Neuropsychopharmacology25: 651-661
40.
Brassett-Grundy A , Butler N (2004a) Attention-Deficit/Hyperactivity Disorder: An overview and review of the literature relating to the correlates and lifecourse outcomes for males and females. Bedford Group for Lifecourse and Statistical Studies Occasional Paper: No. 1. Institute of Education, University of London
41.
Brassett-Grundy A , Butler N (2004b) Prevalence and Adult Outcomes of Attention-Deficit/Hyperactivity Disorder: Evidence from a 30-year prospective longitudinal study. Bedford Group for Lifecourse and Statistical Studies Occasional Paper: No. 2. Institute of Education, University of London
42.
Brookes K , Mill J , Guindalini C , Curran S , Xu X , Knight J , Chen C K , Huang Y S , Sethna V , Taylor E , Chen W , Breen G , Asherson P (2006) A common haplotype of the dopamine transporter gene associated with attention deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy . Arch Gen Psychiatry63: 74-81
43.
Brown T E (1996) Brown Attention-Deficit Disorder Scales. The Psychological Corporation, San Antonio, TX
44.
Burt S A , McGue M , Krueger R F , Iacono W G (2005) Sources of covariation among the child-externalizing disorders: informant effects and the shared environment . Psychol Med35: 1133-1144
45.
Bush G , Valera E M , Seidman L J (2005) Functional neuroimaging of attention-deficit/hyperactivity disorder: a review and suggested future directions . Biol Psychiatry57: 1273-1284
46.
Bymaster F P , Katner J S , Nelson D L , Hemrick-Luecke S K , Threlkeld P G , Heiligenstein J H , Morin S M , Gehlert D R , Perry K W (2002) Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder . Neuropsychopharmacology27: 699-711
47.
Carlezon WA Jr , Mague S D , Andersen S L (2003) Enduring behavioral effects of early exposure to methylphenidate in rats . Biol Psychiatry54: 1330-1337
48.
Carter C M , Urbanowicz M , Hemsley R , Mantilla L , Strobel S , Graham P J , Taylor E (1993) Effects of a few food diet in attention deficit disorder . Arch Dis Child69: 564-568
49.
Castellanos F X , Lee P P , Sharp W , Jeffries N O , Greenstein D K , Clasen L S , Blumenthal J D , James R S , Ebens C L , Walter J M , Zijdenbos A , Evans A C , Giedd J N , Rapoport J L (2002) Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder . JAMA288: 1740-1748
50.
Castellanos X , Sonuga-Barke E J S , Tannock R , Milham M (2006) Characterising cognition in ADHD: beyond executive dysfunction . Trends Cogn Sci10: 117-123
51.
Cheon K A , Ryu Y H , Kim Y K , Namkoong K , Kim C H , Lee J D (2003) Dopamine transporter density in the basal ganglia assessed with [123I]IPT SPET in children with attention deficit hyperactivity disorder . Eur J Nucl Med Mol Imaging30: 306-311
52.
Coghill D (2006) Making the most of scant resources. In Yule W (ed.), The ADHD Spectrum. ACAMH Occasional papers 24, ACAMH, London
53.
Coghill D , Nigg J , Rothenberger A , Sonuga-Barke E , Tannock R (2005) Whither causal models in the neuroscience of ADHD?Dev Sci8: 105-114
54.
Conners C K , Erhardt D , Sparrow E , Conners M A (1998) CAARS Adult ADHD Rating Scales. Multi Health Systems Inc., New York
55.
Craney J L , Geller B (2003) A prepubertal and early adolescent bipolar disorder-I phenotype: review of phenomenology and longitudinal course . Bipolar Disord5: 243-256
56.
Dalteg A , Levander S (1998) Twelve thousand crimes by 75 boys: a 20-year follow-up study of childhood hyperactivity . J Forensic Psychiatry9: 39-57
57.
Dalteg A , Lindgren M , Levander S (1999) Retrospectively rated ADHD is linked to specific personality characteristics and deviant alcohol reaction . J Forensic Psychiatry10: 623-634
58.
DelBello M P , Soutullo C A , Niemeier R T , Wigh W L , McElroy S L , Strakowski S M (2001) Prior stimulant treatment in adolescents with bipolar disorder: association with age at onset . Bipolar Disord3: 53-57
59.
Department of Health (2004) National Service Framework for Children, Young People and Maternity Services. Department of Health Publications . Available at: http://www.dh.gov.uk/PolicyAndGuidance/HealthAndSocialCareTopics/ChildrenServices/fs/en
60.
Dick D M , Viken R J , Kaprio J , Pulkkinen L , Rose R J (2005) Understanding the covariation among childhood externalizing symptoms: genetic and environmental influences on conduct disorder, attention deficit hyperactivity disorder, and oppositional defiant disorder symptoms . J Abnorm Child Psychol33: 219-229
61.
Dickerson Mayes S , Calhoun S L , Crowell E W (2001) Clinical validity and interpretation of the Gordon Diagnostic System in ADHD assessments . Neuropsychol Dev Cogn C Child Neuropsychol7: 32-41
62.
Dougherty D D , Bonab A A , Spencer T J , Rauch S L , Madras B K , Fischman A J (1999) Dopamine transporter density in patients with attention deficit hyperactivity disorder . Lancet354: 2132-2133
63.
Doyle A E , Biederman J , Siedman L J , Weber W , Faraone S V (2000) Diagnostic efficiency of neuropsychological test scores for discriminating boys with and without attention deficit-hyperactivity disorder . J Consult Clin Psychol68: 477-488
64.
Doyle A E , Willcutt E G , Siedman L J , Biederman J , Chouinard V A , Silva J , Faraone S V (2005) Attention-deficit/hyperactivity disorder endophenotypes . Biol Psychiatry57: 1324-1335
65.
Dresel S , Krause J , Krause K H , LaFougere C , Brinkbaumer K , Kung H F , Hahn K , Tatsch K (2000) Attention deficit hyperactivity disorder: binding of [99mTc]TRODAT-1 to the dopamine transporter before and after methylphenidate treatment . Eur J Nucl Med27: 1518-1524
66.
Dykman K D , Dykman R A (1998) Effect of nutritional supplements on attentional-deficit hyperactivity disorder . Integr Physiol Behav Sci33: 49-60
67.
Egger J , Carter C M , Graham P J , Gumley D , Soothill J F (1985) Controlled trial of oligoantigenic treatment in the hyperkinetic syndrome . Lancet9(1): 540-545
68.
Eyestone L L , Howell R J (1994) An epidemiological study of attention-deficit hyperactivity disorder and major depression in a male prison population . Bull Am Acad Psychiatry Law22: 181-193
69.
Faraone S V , Biederman J (2005) What is the prevalence of adult ADHD? Results of a population screen of 966 adults . J Atten Disord9: 384-391
70.
Faraone S V , Biederman J , Mick E (2006) The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies . Psychol Med36: 159-165
71.
Faraone S V , Biederman J , Monuteaux M C (2000) Toward guidelines for pedigree selection in genetic studies of attention deficit hyperactivity disorder . Genet Epidemiol18: 1-16
72.
Faraone S V , Biederman J , Mennin D , Gershon J , Tsuang M T (1996) A prospective four-year follow-up study of children at risk for ADHD: psychiatric, neuropsychological, and psychosocial outcome . J Am Acad Child Adolesc Psychiatry35: 1449-1459
73.
Faraone S V , Spencer T , Aleardi M , Pagano C , Biederman J (2004) Meta-analysis of the efficacy of methylphenidate for treating adult attention-deficit/hyperactivity disorder . J Clin Psychopharmacol24: 24-29
74.
Faraone S V , Biederman J , Spencer T , Michelson D , Adler L , Reimherr F , Glatt S J (2005a) Efficacy of atomoxetine in adult attention-deficit/hyperactivity disorder: a drug-placebo response curve analysis . Behav Brain Funct1: 16-16
75.
Faraone S V , Perlis R H , Doyle A E , Smoller J W , Goralnick J J , Holm-gren M A , Sklar P (2005b) Molecular genetics of attention-deficit/hyperactivity disorder . Biol Psychiatry57: 1313-1323
76.
Farrington D P (1995) The Twelfth Jack Tizard Memorial Lecture. The development of offending and antisocial behaviour from childhood: key findings from the Cambridge Study in Delinquent Development . J Child Psychol Psychiatry36: 929-964
77.
Ferris R M , Tang F L (1979) Comparison of the effects of the isomers of amphetamine, methylphenidate and deoxypipradrol on the uptake of l-[3H]norepinephrine and [3H]dopamine by synaptic vesicles from rat whole brain, striatum and hypothalamus . J Pharmacol Exp Ther210: 422-428
78.
Findling R , Schwartz M A , Flannery D J , Manos M J (1996) Venlafaxine in adults with attention-deficit/hyperactivity disorder: an open clinical trial . J Clin Psychiatry57: 184-189
79.
Fisher S E , Francks C , McCracken J T , McGough J J , Marlow A J , MacPhie I L , Newbury D F , Crawford L R , Palmer C G , Woodward J A , Del’Homme M , Cantwell D P , Nelson S F , Monaco A P , Smalley S L (2002) A genomewide scan for loci involved in attention-deficit/hyperactivity disorder . Am J Hum Genet70: 1183-1196
80.
Fleckenstein A E , Hanson G R (2003) Impact of psychostimulants on vesicular monoamine transporter function . Eur J Pharmacol479: 283-289
81.
Fone K C , Nutt D J (2005) Stimulants: use and abuse in the treatment of attention deficit hyperactivity disorder . Curr Opin Pharmacol5: 87-93
82.
Frazier T M , Demaree H A , Youngstrom E A (2004) Meta-analysis of intellectual and neuropsychological test performance in ADHD . Neuropsychology18: 543-555
83.
Gadow K , Sprafkin J , Weiss M (1999) Adult Inventories-4. Available at: www.checkmateplus.com
84.
Gadow K D , Nolan E E , Sprafkin J , Sverd J (1995) School observations of children with attention deficit hyperactivity disorder and comorbid tic disorder: effects of methylphenidate treatment . J Dev Behav Pediatr16: 167-177
85.
Galanter C A , Carlson G A , Jensen P S , Greenhill L L , Davies M , Li W , Chuang S Z , Elliott G R , Arnold L E , March J S , Hechtman L , Pelham W E , Swanson J M (2003) Response to methylphenidate in children with attention deficit hyperactivity disorder and manic symptoms in the multimodal treatment study of children with attention deficit hyperactivity disorder titration trial . J Child Adolesc Psychopharmacol13: 123-136
86.
Gallagher R , Blader J (2001) The diagnosis and neuropsychological assessment of adult attention deficit/hyperactivity disorder. Scientific study and practical guidelines . Ann N Y Acad Sci931: 148-171
87.
Gehlert D R , Schober D A , Hemrick-Luecke S K , Krushinski J , Howbert J J , Roberston D W , Fuller R W , Wong D T (1995) Novel halogenated analogs of tomoxetine that are potent and selective inhibitors of norepinephrine uptake in brain . Neurochem Int26: 47-52
88.
Geller B , Zimerman B , Williams M , Bolhofner K , Craney J L , DelBello M P , Soutullo C A (2000a) Six month stability and outcome of a prepubertal and early adolescent bipolar disorder phenotype . J Child Adolesc Psychopharm10: 165-174
89.
Geller B , Zimerman B , Williams M , Bolhofner K , Craney J L , DelBello M P , Soutullo C A (2000b) Diagnostic characteristics of 93 cases of a prepubertal and early adolescent bipolar disorder phenotype by gender, puberty, and comorbid ADHD . J Child Adolesc Psychopharmacol10: 157-164
90.
Gjone H , Stevenson J , Sundet J M (1996) Genetic influence on parent-reported attention-related problems in a Norwegian general population twin sample . J Am Acad Child Adolesc Psychiatry35: 588-596
91.
Gordon M , Antshel K , Faraone S , Barkley R , Lewandowski L , Hudziak J J , Biederman J , Cunningham C (2006) Symptoms versus impairment: the case for respecting DSM-IV’s Criterion D . J Atten Disord9: 465-475
92.
Goodwin G M for the Consensus Group of the British Association of Psychopharmacology (2003) Evidence-based guidelines for treating bipolar disorder: recommendations from the British Association for Psychopharmacology . J Psychopharmacol17: 149-173
93.
Grodzinsky G M , Barkley R A (1999) Predictive power of frontal lobe tests in the diagnosis of attention deficit hyperactivity disorder . Clin Neuropsychol13: 12-21
94.
Gross-Tsur V , Manor O , van der Meere J , Joseph A , Shalev R S (1997) Epilepsy and attention deficit hyperactivity disorder: is methylphenidate safe and effective?J Pediatr130: 40-44
95.
Gucuyener K , Erdemoglu A K , Senol S , Serdaroglu A , Soysal S , Kockar A I (2003) Use of methylphenidate for attention-deficit hyperactivity disorder in patients with epilepsy or electroencephalographic abnormalities . J Child Neurol18: 109-112
96.
Gudjonsson G , Young S (2006) An overlooked vulnerability in a defendant: Attention Deficit Hyperactivity Disorder (ADHD) and a miscarriage of justice . Legal & Criminological Psychology11: 211-218
97.
Handen B L , Feldman H M , Lurier A , Murray P J (1999) Efficacy of methylphenidate among preschool children with developmental disorders and ADHD . J Am Assoc Child Adolesc Psychiatry38: 805-812
98.
Harvey A S , Epstein J N , Curry J F (2004) Neuropsychology of adults with AD/HD: A meta-analytic review . Neuropsychology18: 485-503
99.
Hebebrand J , Dempfle A , Saar K , Thiele H , Herpertz-Dahlmann B , Linder M , Kiefl H , Remschmidt H , Hemminger U , Warnke A , Knolker U , Heiser P , Friedel S , Hinney A , Schafer H , Nurnberg P , Konrad K (2005) A genome-wide scan for attention-deficit/hyperactivity disorder in 155 German sib-pairs . Mol Psychiatr11: 196-205
100.
Hechtman L , Greenfield B (2003) Long-term use of stimulants in children with attention deficit hyperactivity disorder: safety, efficacy, and long-term outcome . Paediatr Drugs5: 787-794
101.
Hechtman L , Weiss G (1983) Long-term outcome of hyperactive children . Am J Orthopsychiatry53: 532-541
102.
Hechtman L , Weiss G (1986) Controlled prospective fifteen-year followup of hyperactives as adults: non-medical drug and alcohol use and anti-social behaviour . Am J Orthopsychiatry54: 415-425
103.
Hedges D , Reimherr F W , Rogers A , Strong R , Wender P H (1995) An open trial of venlafaxine in adult patients with attention deficit hyperactivity disorder . Psychopharmacol Bull31: 779-783
104.
Heiligenstein E , Keeling R P (1995) Presentation of unrecognized attention deficit hyperactivity disorder in college students . J Am Coll Health43: 226-228
105.
Heinz A , Goldman D , Jones D W , Palmour R , Hommer D , Gorey J G , Lee K S , Linnoila M , Weinberger D R (2000) Genotype influences in vivo dopamine transporter availability in human striatum . Neuropsychopharmacology22: 133-139
106.
Hesslinger B , Tebartz van Elst L , Nyberg E , Dykierek P , Richter H , Berner M , Ebert D (2002) Psychotherapy of attention deficit hyperactivity disorder in adults: a pilot study using a structured skills training program . Eur Arch Psychiatry Clin Neurosci252: 177-184
107.
Hill J C , Schoener E P (1996) Age-dependent decline of attention deficit hyperactivity disorder . Am J Psychiatry153: 1143-1146
108.
Hudziak J J , Derks E M , Althoff R R , Rettew D C , Boomsma D I (2005) The genetic and environmental contributions to attention deficit hyperactivity disorder as measured by the Conner’s Rating Scales-Revised . Am J Psychiatry162: 1614-1620
109.
Jackson D A , King A R (2004) Gender differences in the effects of oppositional behavior on teacher ratings of ADHD symptoms . J Abnorm Child Psychol32: 215-224
110.
Jacobsen L K , Staley J K , Zoghbi S S , Seibyl J P , Kosten T R , Innis R B , Gelernter J (2000) Prediction of dopamine transporter binding availability by genotype: a preliminary report . Am J Psychiatry157: 1700-1703
111.
Jester J M , Nigg J T , Adams K , Fitzgerald H E , Puttler L I , Wong M M , Zucker R A (2005) Inattention/hyperactivity and aggression from early childhood to adolescence: heterogeneity of trajectories and differential influence of family environment characteristics . Dev Psychopathol17: 99-125
112.
Joint Formulary Committee (2005) British National Formulary, 50 ed.British Medical Association and Royal Pharmaceutical Society of Great Britain, London
113.
Kahn R S , Khoury J , Nichols W C , Lanphear B P (2003) Role of dopamine transporter genotype and maternal prenatal smoking in childhood hyperactive-impulsive, inattentive, and oppositional behaviors . J Pediatr143: 104-110
114.
Kessler R C , Adler L , Ames M , Demler O , Faraone S , Hiripi E , Howes M J , Jin R , Secnik K , Spencer T , Ustun T B , Walters E E (2005) The World Health Organization Adult ADHD Self-Report Scale (ASRS): a short screening scale for use in the general population . Psychol Med35: 245-256
115.
Kessler R C , Adler L , Barkley R , Biederman J , Conners C K , Demler O , Faraone S V , Greenhill L L , Howes M J , Secnik K , Spencer T , Ustun T B , Walters E E , Zaslavsky AM (2006) Prevalence of adult ADHD in the United States: results from the National Comorbidity Survey Replication (NCS-R) . Am J Psychiatry163: 716-723
116.
Kollins S H (2003) Comparing the abuse potential of methylphenidate versus other stimulants: a review of available evidence and relevance to the ADHD patient . J Clin Psych64 (suppl. II): 14-18
117.
Kooij J J , Aeckerlin L P , Buitelaar J K (2001) [Functioning, comorbidity and treatment of 141 adults with attention deficit hyperactivity disorder (ADHD) at a psychiatric outpatient department] . Ned Tijdschr Geneeskd145: 1498-1501
118.
Kooij J J , Burger H , Boonstra A M , Van der Linden P D , Kalma L E , Buitelaar J K (2004) Efficacy and safety of methylphenidate in 45 adults with attention-deficit/hyperactivity disorder. A randomized placebo-controlled double-blind cross-over trial . Psychol Med34: 973-982
119.
Kooij J J , Buitelaar J K , van den Oord E J , Furer J W , Rijnders C A , Hodiamont P P (2005) Internal and external validity of attention-deficit hyperactivity disorder in a population-based sample of adults . Psychol Med35: 817-827
120.
Kratochvil C J , Newcorn J H , Arnold L E , Duesenberg D , Emslie G J , Quintana H , Sarkis E H , Wagner K D , Gao H , Michelson D , Biederman J (2005) Atomoxetine alone or combined with fluoxetine for treating ADHD with comorbid depressive or anxiety symptoms . J Am Acad Child Adolesc Psychiatry44: 915-924
121.
Krause K H , Dresel S H , Krause J , Kung H F , Tatsch K (2000) Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: effects of methylphenidate as measured by single photon emission computed tomography . Neurosci Lett285: 107-110
122.
Kuczenski R , Segal D S (2001) Locomotor effects of acute and repeated threshold doses of amphetamine and methylphenidate: relative roles of dopamine and norepinephrine . J Pharmacol Exp Ther296: 876-883
123.
Kuczenski R , Segal D S (2002) Exposure of adolescent rats to oral methylphenidate: preferential effects on extracellular norepinephrine and absence of sensitization and cross-sensitization to methamphetamine . J Neurosci22: 7264-7271
124.
Kuo F E , Taylor A F (2005) A potential natural treatment for attention-deficit/hyperactivity disorder: evidence from a national study . Am J Public Health94: 1580-1586
125.
Lambert N M (1988) Adolescent outcomes for hyperactive children. Perspectives on general and specific patterns of childhood risk for adolescent educational, social and mental health problems . Am Psychologist43: 786-799
126.
Levin F R , Evans S M , McDowell D M , Kleber H D (1998) Methylphenidate treatment for cocaine abusers with adult attention-deficit/hyperactivity disorder: a pilot study . J Clin Psychiatry59: 300-305
127.
Levy F , Hay D A , McStephen M , Wood C , Waldman I (1997) Attention-deficit hyperactivity disorder: a category or a continuum? Genetic analysis of a large-scale twin study . J Am Acad Child Adolesc Psychiatry36: 737-744
128.
Lin J S , Hou Y , Jouvet M (1996) Potential brain neuronal targets for amphetamine-, methylphenidate-, and modafinil-induced wakefulness, evidenced by c-fos immunocytochemistry in the cat . Proc Natl Acad Sci U S A93: 14128-14133
129.
Lingford-Hughes A R , Welch S , Nutt D J (2004) Evidence-based guidelines for the pharmacological management of substance misuse, addiction and comorbidity: recommendations from the British Association of Psychopharmacology . J Psychopharmacol18: 293-335
130.
Lovejoy D W , Ball J D , Keats M , Stutts M L , Spain E H , Janda L , Janusz J (1999) Neuropsychological performance of adults with attention deficit hyperactivity disorder (ADHD): diagnostic classification estimates for measures of frontal lobe/executive functioning . J Int Neuropsychol Soc5: 222-233
131.
Luman M , Oosterlaan J , Sergeant J (2005) The impact of reinforcement contingencies on ADHD: a review and theoretical appraisal . Clin Psychol Rev25: 183-213
132.
Lynn D E , Lubke G , Yang M , McCracken J T , McGough J J , Ishii J , Loo S K , Nelson S F , Smalley S L (2005) Temperament and character profiles and the dopamine D4 receptor gene in ADHD . Am J Psychiatry162: 906-913
133.
McCracken J T , McGough J , Shah B , Cronin P , Hong D , Aman M G , Arnold L E , Lindsay R , Nash P , Hollway J , McDougle C J , Posey D , Swiezy N , Kohn A , Scahill L , Martin A , Koenig K , Volkmar F , Carroll D , Lancor A , Tierney E , Ghuman J , Gonzalez N M , Grados M , Vitiello B , Ritz L , Davies M , Robinson J , McMahon D , Research Units on Pediatric Psychopharmacology Autism Network (2002) Risperidone in children with autism and serious behavioral problems . N Engl J Med347: 314-321
134.
McGough J J , Smalley S L , McCracken J T , Del’Homme M , Lynn D E , Loo S (2005) Psychiatric comorbidity in adult attention deficit hyper-activity disorder: findings from multiplex families . Am J Psychiatry162: 1621-1627
135.
Madras B K , Miller G M , Fischman A J (2002) The dopamine transporter: relevance to attention deficit hyperactivity disorder (ADHD) . Behav Brain Res130: 57-63
136.
Magnusson P , Smari J , Sigurdardottir D , Baldursson G , Sigmundsson J , Kristjansson K , Sigurdardottir S , Hreidarsson S , Sigurbjornsdottir S , Gudmundsson O O (2006) Validity of self-report and informant rating scales of adult ADHD symptoms in comparison with a semistructured diagnostic interview . J Atten Disord9: 494-503
137.
Maidment I D (2003a) Efficacy of stimulants in adult ADHD . Ann Pharmacother37: 1884-1890
138.
Maidment I D (2003b) The use of antidepressants to treat attention deficit hyperactivity disorder in adults . J Psychopharmacol17: 332-336
139.
Mannuzza S , Klein R G , Konig P H , Giampino T L (1989) Hyperactive boys almost grown up: IV. Criminality and its relationship to psychiatric status . Arch Gen Psychiatry46: 1073-1079
140.
Mannuzza S , Klein R G , Bessler A , Malloy P , LaPadula M (1998) Adult psychiatric status of hyperactive boys grown up . Am J Psychiatry155: 493-498
141.
Marks D J , Newcorn J H , Halperin J M (2001) Comorbidity in adults with attention-deficit/hyperactivity disorder . Ann N Y Acad Sci931: 216-238
142.
Marotta P J , Roberts E A (1998) Pemoline hepatotoxicity in children . J Pediatr132: 894-897
143.
Martinez D , Gelernter J , Abi-Dargham A , van Dyck C H , Kegeles L , Innis R B , Laruelle M (2001) The variable number of tandem repeats polymorphism of the dopamine transporter gene is not associated with significant change in dopamine transporter phenotype in humans . Neuropsychopharmacology24: 553-560
144.
Mattes J A , Boswell L , Oliver H (1984) Methylphenidate effects on symptoms of attention deficit disorder in adults . Arch Gen Psychiatry41: 1059-1063
145.
Mayes S D , Calhoun S L (2006) WISC-IV and WISC-III profiles in children with ADHD . J Atten Disord9: 486-493
146.
Mayes S D , Crites D L , Bixler E O , Humphrey F J 2nd , Mattison R E (1994) Methylphenidate and ADHD: influence of age, IQ and neurodevelopmental status . Dev Med Child Neurol36: 1099-1107
147.
Michelson D , Adler L , Spencer T , Reimherr F W , West S A , Allen A J , Kelsey D , Wernicke J , Dietrich A , Milton D (2003) Atomoxetine in adults with ADHD: two randomized, placebo-controlled studies . Biol Psychiatry53: 112-120
148.
Mick E , Faraone S V , Biederman J (2004) Age-dependent expression of attention-deficit/hyperactivity disorder symptoms . Psychiatr Clin North Am27: 215-224
149.
Millstein R , Wilens T , Biederman J , Spencer T (1998) Presenting ADHD symptoms and subtypes in clinically referred adults with ADHD . Attention2: 159-166
150.
Montgomery S A , Cowen P J , Deakin W , Freeling P , Hallstrom C , Katona C , King D , Leonard B , Levine S , Phanjoo A , Peet M , Thompson C (1993) Guidelines for the treating depressive illness with antidepressants. A statement from the British Association for Psychopharmacology . J Psychopharmacol7: 19-23
151.
MTA Cooperative Group (1999) A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. Multi-modal Treatment Study of Children with ADHD . Arch Gen Psychiatry56: 1073-1086
152.
Muglia P , Jain U , Macciardi F , Kennedy J L (2000) Adult attention deficit hyperactivity disorder and the dopamine D4 receptor gene . Am J Med Genet96: 273-277
153.
Murphy K R , Barkley R A (1996) Parents of children with attention-deficit/hyperactivity disorder: psychological and attentional impairment . American J Orthopsychiatry66: 93-102
154.
NICE (2006) Methylphenidate, atomoxetine and dexamfetamine for attention deficit hyperactivity disorder (ADHD) in children and adolescents -guidance. National Institute for Health and Clinical Excellence (TA098). Available at: www.nice.org.uk/
155.
Nigg J T (2005) Neuropsychologic theory and findings in attention-deficit/hyperactivity disorder: the state of the field and salient challenges for the coming decade . Biol Psychiatry57: 1424-1435
156.
Ogdie M N , Fisher S E , Yang M , Ishii J , Francks C , Loo S K , Cantor R M , McCracken J T , McGough J J , Smalley S L , Nelson S F (2004) Attention deficit hyperactivity disorder: fine mapping supports linkage to 5p13, 6q12, 16p13, and 17p11 . Am J Hum Genet75: 661-668
157.
Ogdie M N , Macphie I L , Minassian S L , Yang M , Fisher S E , Francks C , Cantor R M , McCracken J T , McGough J J , Nelson S F , Monaco A P , Smalley S L (2003) A genomewide scan for attention-deficit/hyperactivity disorder in an extended sample: suggestive linkage on 17p11 . Am J Hum Genet72: 1268-1279
158.
Paterson R , Douglas C , Hallmayer J , Hagan M , Krupenia Z (1999) A randomised, double-blind, placebo-controlled trial of dexamphetamine in adults with attention deficit hyperactivity disorder . Aust N Z J Psychiatry33: 494-502
159.
Pineda D , Ardila A , Rosselli M , Arias B E , Henao G C , Gomez L F , Mejia S E , Miranda M L (1999) Prevalence of attention-deficit/hyperactivity disorder symptoms in 4-to 17-year-old children in the general population . J Abnorm Child Psychol27: 455-462
160.
Post R M , Chang K D , Findling R L , Geller B , Kowatch R A , Kutcher S P , Leverich G S (2004) Prepubertal bipolar I disorder and bipolar disorder NOS are separable from ADHD . J Clin Psychiatry65: 898-902
161.
Pratt T C , Cullen F T , Blevins K R , Daigle L , Unnever J D (2002) The relationship of attention deficit hyperactivity disorder to crime and delinquency: a meta-analysis . Int J Police Sci Management4: 344-360
162.
Price T S , Simonoff E , Waldman I , Asherson P , Plomin R (2001) Hyperactivity in preschool children is highly heritable . J Am Acad Child Adolesc Psychiatry40: 1362-1364
163.
Rasmussen K , Almik R , Levander S (2001) Attention deficit hyperactivity disorder, reading disability and personality disorders in a prison population . J Am Acad Psychiatry Law296: 186-193
164.
Ratey J J , Greenberg M S , Bemporad J R , Lindem K J (1992) Unrecognized attention-deficit hyperactivity disorder in adults presenting for outpatient psychotherapy . J Child Adolesc Psychopharmacology2: 267-275
165.
Remschmidt H , Global ADHD Working Group (2005) Global consensus on ADHD/HKD . Eur Child Adolesc Psychiatry14: 127-137
166.
Retz W , Retz-Junginger P , Hengesch G , Schneider M , Thome J , Pajonk F G , Salahi-Disfan A , Rees O , Wender P H , Rosler M (2004) Psychometric and psychopathological characterization of young male prison inmates with and without attention deficit/hyperactivity disorder . Eur Arch Psychiatry Clin Neurosci254: 201-208
167.
Rielly N E , Cunningham C E , Richards J E , Elbard H J , Mahoney W J (1999) Detecting attention deficit hyperactivity disorder in a communications clinic: diagnostic utility of the Gordon Diagnostic System . J Clin Exp Neuropsychol21: 685-700
168.
Rhodes S M , Coghill D R , Matthews K (2004) Methylphenidate restores visual memory, but not working memory function in attention deficithyperkinetic disorder . Psychopharmacology (Berl)175: 319-330
169.
Rhodes S M , Coghill D R , Matthews K (2005) Neuropsychological functioning in stimulant-naive boys with hyperkinetic disorder . Psychol Med35: 1109-1120
170.
Richardson A J , Puri B K (2002) A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties . Prog Neuropsychopharmacol Biol Psychiatry26: 233-239
171.
Rosler M , Retz W , Retz-Junginger P , Hengesch G , Schneider M , Supprian T , Schwitzgebel P , Pinhard K , Dovi-Akue N , Wender P , Thome J (2004) Prevalence of attention-deficit/hyperactivity disorder (ADHD) and comorbid disorders in young male prison inmates . Eur Arch Psychiatry Clin Neurosci254: 365-371
172.
Rowe K S , Rowe K J (1994) Synthetic food coloring and behaviour: a dose response effect in a double-blind, placebo-controlled, repeated measures study . J Pediatr125: 691-698
173.
Rowland A S , Lesesne C A , Abramowitz A J (2002) The epidemiology of attention-deficit/hyperactivity disorder (ADHD): a public health view . Ment Retard Dev Disabil Res Rev8: 162-170
174.
Safren S A , Sprich S , Perlman C A , Otto M W (2005a) Mastering Your Adult ADHD. Guilford Press, New York
175.
Safren S A , Otto M W , Sprich S , Winett C L , Wilens T E , Biederman J (2005b) Cognitive-behavioral therapy for ADHD in medication-treated adults with continued symptoms . Behav Res Ther43: 831-842
176.
Santosh P J , Taylor E (2000) Stimulant drugs . Eur Child Adolesc Psychiatry9 (Suppl. 1): I27-I43
177.
Satterfield J H , Hoppe C M , Schell A M (1982) A prospective study of delinquency in 110 adolescent boys with attention deficit disorder and 88 normal adolescent boys . Am J Psychiatry139: 795-798
178.
Satterfield T , Swanson J , Schell A , Lee F (1994) Prediction of anti-social behaviour in attention-deficit hyperactivity disorder boys from aggression/defiance scores . J Am Acad Child Adolesc Psychiatry33: 185-190
179.
Schachter H M , Pham B , King J , Langford S , Moher D (2001) How efficacious and safe is short-acting methylphenidate for the treatment of attention-deficit disorder in children and adolescents? A meta-analysis . CMAJ165: 1475-1488
180.
Schmidt M H , Mocks P , Lay B , Eisert H G , Fojkar R , Fritz-Sigmund D , Marcus A , Musaeus B (1997) Does oligoantigenic diet influence hyperactive/conduct-disordered children -a controlled trial . Eur Child Adolesc Psychiatry6: 88-95
181.
Schoechlin C , Engel R R (2005) Neuropsychological performance in adult attention-deficit hyperactivity disorder: meta-analysis of empirical data . Arch Clin Neuropsychol20: 727-744
182.
Seager M C , O’Brien G (2003) Attention deficit hyperactivity disorder: a review in learning disability: the Diagnostic Criteria for Psychiatric Disorders for Use with Adults with Learning Disabilities/Mental Retardation [DC/LD] criteria for diagnosis . J Intellectual Disability Res475 (suppl. 1): 26-31
183.
Secnik K , Swensen A , Lage M J (2005) Comorbidities and costs of adult patients diagnosed with attention-deficit hyperactivity disorder . Pharmacoeconomics23: 93-102
184.
Seidman L , Doyle A , Fried R , Valera E , Crum K , Matthews L (2004) Neuropsychological function in adults with attention deficit disorder . Psychiatric Clinics of North America27: 261-282
185.
Seidman L J , Valera E M , Makris N (2005) Structural brain imaging of attention-deficit/hyperactivity disorder . Biol Psychiatry57: 1263-1272
186.
Sergeant J A (2005) Modeling attention-deficit/hyperactivity disorder: a critical appraisal of the cognitive-energetic model . Biol Psychiatry57: 1248-1255
187.
Shaffer D , Gould M S , Brasic J , Ambrosini P , Fisher P , Bird H , Aluwahlia S (1983) A children’s global assessment scale (CGAS) . Arch Gen Psychiatry40: 1228-1231
188.
Sharma V , Halperin J H , Newcorn J N , Wolf L E (1991) The dimension of focussed attention: relationship to behavior and cognitive functioning in children . Percept Mot Skills72: 787-793
189.
Shekelle P G , Woolf S H , Eccles M , Grimshaw J (1999) Clinical guidelines: developing guidelines . BMJ318: 593-596
190.
Smalley S L , Kustanovich V , Minassian S L , Stone J L , Ogdie M N , McGough J J , McCracken J T , MacPhie I L , Francks C , Fisher S E , Cantor R M , Monaco A P , Nelson S F (2002) Genetic linkage of attention-deficit/hyperactivity disorder on chromosome 16p13, in a region implicated in autism . Am J Hum Genet71: 959-963
191.
Smith B H , Waschbusch D A , Willoughby M T , Evans S (2000) The efficacy, safety, and practicality of treatments for adolescents with attention-deficit/hyperactivity disorder (ADHD) . Clin Child Fam Psychol Rev3: 243-267
192.
Sonuga-Barke E J (2002) Psychological heterogeneity in AD/HD -a dual pathway model of behaviour and cognition . Behav Brain Res130: 29-36
193.
Sonuga-Barke E J (2003) The dual pathway model of AD/HD: an elaboration of neuro-developmental characteristics . Neurosci Biobehav Rev27: 593-604
194.
Sonuga-Barke E J (2005) Causal models of attention-deficit/hyperactivity disorder: from common simple deficits to multiple developmental pathways . Biol Psychiatry57: 1231-1238
195.
Sonuga-Barke E J , Elgie S , Hall M (2005) More to ADHD than meets the eye: observable abnormalities in search behaviour do not account for performance deficits on a discrimination task . Behav Brain Funct20: 10-10
196.
Sonuga-Barke E J , Swanson J M , Coghill D , DeCory H H , Hatch S J (2004) Efficacy of two once-daily methylphenidate formulations compared across dose levels at different times of the day: preliminary indications from a secondary analysis of the COMACS study data . BMC Psychiatry4: 28-28
197.
Spencer T , Biederman J , Wilens THarding M , O’Donnell D , Griffin S (1996) Pharmacotherapy of attention-deficit/hyperactivity disorder across the life cycle . J Am Acad Child Adolesc Psychiatry35: 409-432
198.
Spencer T J , Biederman J , Madras B K , Faraone S V , Dougherty D D , Bonab A A , Fischman A J (2005a) In vivo neuroreceptor imaging in attention-deficit/hyperactivity disorder: a focus on the dopamine transporter . Biol Psychiatry57: 1293-1300
199.
Spencer T , Biederman J , Wilens T , Faraone S , Prince J , Gerard K , Doyle R , Parekh A , Kagan J , Bearman S K (2001) Efficacy of a mixed amphetamine salts compound in adults with attention-deficit/hyperactivity disorder . Arch Gen Psychiatry58: 775-782
200.
Spencer T , Biederman J , Wilens T , Doyle R , Surman C , Prince J , Mick E , Aleardi M , Herzig K , Faraone S (2005b) A large, double-blind, randomized clinical trial of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder . Biol Psychiatry57: 456-463
201.
Steele M , Weiss M D , Swanson J M , Wang J , Prinzo R S , Binder C E (2006) A randomized, controlled, effectiveness trial of OROS methylphenidate compared to usual care with immediate release methylphenidate in attention deficit-hyperactivity disorder . Can J Clin Pharmacol13: e50-e62
202.
Stein M A , Waldman I D , Sarampote C S , Seymour K E , Robb A S , Conlon C , Kim S J , Cook E H (2005) Dopamine transporter genotype and methylphenidate dose response in children with ADHD . Neuropsychopharmacology30: 1374-1382
203.
Stevenson C S , Whitmont S , Bornholt L , Livesey D , Stevenson R J (2002) A cognitive remediation programme for adults with attention deficit hyperactivity disorder . Aust N Z J Psychiatry36: 610-616
204.
Swanson C J , Perry K W , Koch-Krueger S , Katner J , Svensson K A , Bymaster F P (2006) Effect of the attention deficit/hyperactivity disorder drug atomoxetine on extracellular concentrations of norepinephrine and dopamine in several brain regions of the rat . Neuropharmacology50: 755-760
205.
Swanson J M , Wigal S B , Wigal T , Sonuga-Barke E , Greenhill L L , Biederman J , Kollins S , Nguven A S , DeCory H H , Hirshe Dirksen S J , Hatch S J , COMACS Study Group (2004) A comparison of once-daily extended-release methylphenidate formulations in children with attention-deficit/hyperactivity disorder in the laboratory school (the Comacs Study) . Pediatrics113: e206-e216
206.
Swensen A , Birnbaum H G , Ben Hamadi R , Greenberg P , Cremieux P Y , Secnik K (2000) Incidence and costs of accidents among attention-deficit/hyperactivity disorder patients . J Adolesc Health35: 346-349
207.
Tamm L , Menon V , Ringel J , Reiss A L (2004) Event-related fMRI evidence of frontotemporal involvement in aberrant response inhibition and task switching in attention-deficit/hyperactivity disorder . J Am Acad Child Adolesc Psychiatry43: 1430-1440
208.
Tan M , Appleton R (2005) Attention deficit and hyperactivity disorder, methylphenidate, and epilepsy . Arch Dis Child90: 57-59
209.
Taylor E , Chadwick O , Heptinstall E , Danckaerts M (1996) Hyperactivity and conduct problems as risk factors for adolescent development . J Am Acad Child Adolesc Psychiatry35: 1213-1226
210.
Taylor E , Dopfner M , Sergeant J , Asherson P , Banaschewski T , Buitelaar J , Coghill D , Danckaerts M , Rothenberger A , Sonuga-Barke E , Steinhausen H C , Zuddas A (2004) European clinical guidelines for hyper-kinetic disorder -first upgrade . Eur Child Adolesc Psychiatry13 (suppl. 1): I7-I30
211.
Taylor F B , Russo J (2000) Efficacy of modafinil compared to dextroamphetamine for the treatment of attention deficit hyperactivity disorder in adults . J Child Adolesc Psychopharmacol10: 311-320
212.
Taylor F B , Russo J (2001) Comparing guanfacine and dextroamphetamine for the treatment of adult attention-deficit/hyperactivity disorder . J Clin Psychopharmacol21: 223-228
213.
Thapar A , Harrington R , McGuffin P (2001) Examining the comorbidity of ADHD-related behaviours and conduct problems using a twin study design . Br J Psychiatry179: 224-229
214.
Thapar A , O’Donovan M , Owen M J (2005a) The genetics of attention deficit hyperactivity disorder . Hum Mol Genet14 (Spec No. 2): R275-R282
215.
Thapar A , Langley K , Fowler T , Rice F , Turic D , Whittinger N , Aggleton J , Van den Bree M , Owen M , O’Donovan M (2005b) Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder . Arch Gen Psychiatry62: 1275-1278
216.
Thomason C , Michelson D (2004) Atomoxetine -treatment of attention deficit hyperactivity disorder: beyond stimulants . Drugs Today (Barc)40: 465-473
217.
Toplak M E , Dockstader C , Tannock R (2006) Temporal information processing in ADHD: findings to date and new methods151(1): 15-29
218.
Torgersen T , Gjervan B , Rasmussen K (2006) ADHD in adults: a study of clinical characteristics, impairment and comorbidity . Nord J Psychiatry60: 38-43
219.
Tripp G , Luk S L , Schaughency E A , Singh R (1999) DSM-IV and ICD-10: a comparsion of the correlatoes of ADHD and hyperkinetic disorder . J Am Acad Child Adol Psych38: 156-164
220.
van der Feltz-Cornelis C M , Aldenkamp A P (2006) Effectiveness and safety of methylphenidate in adult attention deficit hyperactivity disorder in patients with epilepsy: an open treatment trial . Epilepsy Behav8: 659-662
221.
Van Dyck , Quinlan D M , Cretella L M , Staley J K , Malison R T , Baldwin R M , Seibyl J P , Innis R B (2002) Unaltered dopamine transporter availability in adult attention deficit disorder . Am J Psychiatry159: 309-312
222.
Vitelli R (1995) Prevalence of childhood conduct and attention-deficit hyperactivity disorders in adult maximum-security inmates . Int J Offender Ther Comp Criminology40: 263-271
223.
Volkow N D , Insel T R (2003) What are the long-term effects of methylphenidate treatment?Biol Psychiatry54: 1307-1309
224.
Volkow N D , Wang G J , Fowler J S , Ding Y S (2005) Imaging the effects of methylphenidate on brain dopamine: new model on its therapeutic actions for attention-deficit/hyperactivity disorder . Biol Psychiatry57: 1410-1415
225.
Volkow N D , Wang G J , Fowler J S , Gatley S J , Logan J , Ding Y S , Hitzemann R , Pappas N (1998) Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate . Am J Psychiatry155: 1325-1331
226.
Volkow N D , Wang G , Fowler J S , Logan J , Gerasimov M , Maynard L , Ding Y , Gatley S J , Gifford A , Franceschi D (2001) Therapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brain . J Neurosci21: RC121-RC121
227.
Volkow N D , Wang G J , Fowler J S , Fischman M , Foltin R , Abumrad N N , Gatley S J , Logan J , Wong C , Gifford A , Ding Y S , Hitzemann R , Pappas N (1999) Methylphenidate and cocaine have a similar in vivo potency to block dopamine transporters in the human brain . Life Sci65: PL7-PL12
228.
Waldman I D (2005) Statistical approaches to complex phenotypes: evaluating neuropsychological endophenotypes for attention-deficit/hyperactivity disorder . Biol Psychiatry57: 1347-1356
229.
Erratum in: 150: 1280-1280
230.
Weiss G , Hechtman L T (1993) Hyperactive Children Grown Up, 2nd edn.Guildford, New York
231.
Weiss M , Murray C (2003) Assessment and management of attention-deficit hyperactivity disorder in adults . CMAJ18: 715-722
232.
Weiss M D , Murray C (2004) Practice Guideline for the Assessment of ADHD in adults. Canadian ADHD Resource Alliance, Vancouver, Canada
233.
Weiss M D , Weiss J R (2004) A guide to the treatment of adults with ADHD . J Clin Psychiatry65 (Suppl 3): 27-37
234.
Wender P H (1995) Attention-deficit hyperactivity disorder in adults. Oxford University Press, New York , pp. 122-143
235.
Wender P H , Reimherr F W (1990) Bupropion treatment of attention-deficit hyperactivity disorder in adults . Am J Psychiatry147: 1018-1020
236.
Wender P H , Wolf L E , Wasserstein J (2001) Adults with ADHD. An overview . Ann N Y Acad Sci931: 1-16
237.
WHO (1992) The ICD-10 classification of mental and behavioural disorders. Geneva, Switzerland
238.
Wiggins D , Singh K , Getz H G , Hutchins D E (1999) Effects of brief group intervention for adults with attention deficit/hyperactivity disorder . J Mental Health Counseling21: 82-92
239.
Wilens T E , Faraone S V , Biederman J , Gunawardene S (2003) Does stimulant therapy of attention-deficit/hyperactivity disorder beget later substance abuse? A meta-analytic review of the literature . Pediatrics111: 179-185
240.
Wilens T E , McDermott S P , Biederman J , Abrantes A , Hahesy A , Spencer T J (1999a) Cognitive therapy in the treatment of adults with ADHD: A systematic chart review of 26 cases . J Cogn Psychother13: 215-226
241.
Wilens T E , Biederman J , Prince J , Spencer T J , Faraone S V , Warburton R , Schleifer D , Harding M , Linehan C , Geller D (1996) Six-week, double-blind, placebo-controlled study of desipramine for adult attention deficit hyperactivity disorder . Am J Psychiatry153: 1147-1153
242.
Wilens T E , Spencer T J , Biederman J , Girard K , Doyle R , Prince J , Polisner D , Solhkhah R , Comeau S , Monuteaux M C , Parekh A (2001) A controlled clinical trial of bupropion for attention deficit hyperactivity disorder in adults . Am J Psychiatry158: 282-288
243.
Wilens T E , Biederman J , Spencer T J , Frazier J , Prince J , Bostic J , Rater M , Soriano J , Hatch M , Sienna M , Millstein R B , Abrantes A (1999b) Controlled trial of high doses of pemoline for adults with attention-deficit/hyperactivity disorder . J Clin Psychopharmacol19: 257-264
244.
Willcutt E G , Pennington B F , DeFries J C (2000) Twin study of the etiology of comorbidity between reading disability and attention-deficit/hyperactivity disorder . Am J Med Genet96: 293-301
245.
Willcutt E G , Doyle A E , Nigg J T , Faraone S V , Pennington B F (2005) Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review . Biol Psychiatry57: 1336-1346
246.
World Health Organization (1992) The ICD-10 classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines. World Health Organization, Geneva
247.
Young S , Gudjonsson G , Ball S , Lam J (2003) Attention deficit hyperactivity disorder in personality disordered offenders and the association with disruptive behavioural problems . J Forensic Psychiatry Psychol14: 491-505
248.
Young S J , Gudjonsson G (submitted) Growing out of attention-deficit/hyperactivity disorder: the relationship between functioning and symptoms
249.
Young S J , Harty M A (2001) Treatment issues in a personality disordered offender: a case of attention deficit hyperactivity disorder in secure psychiatric services . J Forensic Psychiatry12: 158-167
250.
Young S J , Ross R R (2006) R&R2 for ADHD youth and adults. A handbook for teaching prosocial competence. Cognitive Centre of Canada, Ottawa (cogcen@canada.com)
251.
Young S J , Ross R R (in preparation) R&R2 for ADHD children. A handbook for teaching prosocial competence
