We report the case of a 44-year-old female patient with paranoid schizophrenia, who developed blepharospasm on risperidone treatment, but who was successfully rechallenged by risperidone without recurrence of blepharospasm. Possible mechanisms of action and implications for clinical care are discussed.
Ananth J , Edelmuth E , Dargan B (1988) Meige’s syndrome associated with neuroleptic treatment . Am J Psychiatry145: 513–515
2.
Casey D E (1999) Tardive dyskinesia and atypical antipsychotic drugs . Schizophrenia Res34 (Suppl): 61–66
3.
Dursun S M , Hewitt S , King A I , Reveley M A (1996) Treatment of blepharospasm with nicotine nasal spray . Lancet348: 60-60
4.
Chong S A , Remington G , Tan C H (1999) Risperidone treatment of tardive dyskinesia and dystonia . J Clin Psychiatry60: 340–341
5.
Gardos G , Cole J O , Salomon M , Schniebolk S (1987) Clinical forms of severe tardive dyskinesia . Am J Psychiatry144: 895–902
6.
Grandas F , Elston J , Quinn N , Marsden C D (1988) Blepharospasm: a review of 264 patients . J Neurol Neurosurg Psychiatry51(6): 767–772
7.
Jankovic J , Ford J (1983) Blepharospasm and orofacial-cervical dystonia: clinical and pharmacological findings in 100 patients . Am Neurol13: 402–411
8.
Jankovic J , Patel S C (1983) Blepharospasm associated with brain stem lesion . Neurology33: 1237–1240
9.
Kopala L C , Honer W G (1994) Schizophrenia and severe tardive dyskinesia responsive to risperidone . J Clin Psychopharmacol14: 430–431
10.
Levin H , Reddy R (2000) Clozapine in the treatment of neurolepticinduced blepharospasm: a report of 4 cases . J Clin Psychiatry61: 140–143
11.
Madhusoodanan S , Brenner R , Moise D , Sindagi J , Brafman I (1998) Psychiatric and neuropsychological abnormalities in Huntington’s disease: the case study . Ann Clin Psychiatry10: 117–120
12.
Mullen A , Cullen M (2000) Risperidone and tardive dyskinesia: a case of blepharospasm . Aust NZ J Psychiatry34: 879–880
13.
Rangwani S R , Gupta S , Burke W J , Potter J (1996) Improvement of debilitating tardive dyskinesia with Risperidone . Ann Clin Psychiatry8: 27–29
14.
Suran B M (1998) Risperidone induced tardive dyskinesia . J Clin Psychiatry59: 29–30