Effects of d-amphetamine on the performance of rats in an animal analogue of the A-X Continuous Performance Test

Abstract

Schizophrenia patients subjected to the A-X Continuous Performance Test (A-X CPT) show cognitive deficits that are thought to reflect impaired representation and maintenance of context information. An issue deserving attention is to what extent the acute amphetamine model of schizophrenia also models these cognitive deficits. The present experiment examined the effect of acute d-amphetamine (AMP) on the performance of rats in an animal analogue of the A-X CPT. Subjects first learned to solve an A [.arrowright] X+, B [.arrowright] X–, A [.arrowright] Y– discrimination task, with A and B representing visual features; X and Y designating auditory target stimuli; [.arrowright] signifying a serial presentation; and + and – referring to food reinforcement and non reinforcement, respectively. Frequency of food-magazine visits was the dependent measure. After mastering the discrimination, rats received test trials under either saline or 0.5 mg/kg AMP (s.c.). At test, the interval between feature and target presentation was varied; reinforcement contingencies were maintained. AMP significantly impaired performance on the A [.arrowright] X+/B [.arrowright] X– discrimination by increasing the response level on B [.arrowright] X– trials. AMP did not significantly affect performance on the A [.arrowright] X+/A [.arrowright] Y– discrimination. However, AMP also increased magazine responding in the absence of the presentation of features and targets. A parsimonious conclusion based on these preliminary results is that acute AMP does not affect processing of context information provided by the visual features in this procedure. It rather has a more nonspecific response-enhancing effect, especially with respect to stimuli associated with the delivery of food.