Reply

Fallon M . Opioid rotation: does it have a role? Palliat Med 1997; 11: 177–178.

Foley KM . Clinical tolerance to opioids. In: Basbaum A , Besson, JM eds Towards a new pharmacotherapy of pain. New York: John Wiley, 1991: 181–203.

Yaksh TL , Harty G . Pharmacology of the allodynia in rats evoked by high dose intrathecal morphine. J Pharmacol Exp Ther 1988; 244: 501–507.

Parkinson SK , Bailly SL , Little WL , Mueuller JB . Myoclonic seizure activity with chronic high-dose spinal opioid administration. Anaesthesiology 1990; 72: 743–745.

Sjøren P , Jonsson T , Jensen NH , Drench NE , Jensen TS . Hyperalgesia and myoclonus in terminal cancer patients treated with continuous intravenous morphine. Pain 1993; 55: 93–97.

Yaksh TL , Harty GJ , Onofrio BM . High doses of spinal morphine produce a non-opiate receptor-mediated hyperesthesia: clinical and theoretical implications. Anesthesiology 1986; 64: 590–597.

Hamon M , Bourgoin S , Le Bars D , Cesselin F . In vivo and in vitro release of central neurotransmitters in relation to pain and analgesia. Prog Brain Res 1988; 77: 431–444.

Siegal S . Morphine tolerance acquisition as an associative process. J Exp Psych Anim Beh Proc 1997; 3: 1–13.

Cox BM . Molecular and cellular mechanisms in opioid tolerance. In: Towards a new pharmaco-therapy of pain. New York: John Wiley, 1991: 137–156.

Houde RW . Nathan B Eddy Memorial Lecture: The analgesic connection. In: Harris LS ed. Problems of drug dependence 1984Proceedings of the 46th Annual Scientific meeting, The Committee on Problems of Drug Dependence. Inc., NIDA Research Monograph 1985: 55; 4–13.

Vigano A , Fan D , Bruera E . Individualised use of methadone and opioid rotation in the comprehensive management of cancer pain associated with poor prognostic indicators. Pain 1996; 67: 115–119.

Crews JC , Sweeney NJ , Denson DD . Clinical efficacy of methadone in patients refractory to other [.mu]-opioid receptor agonist analgesics for management of terminal cancer pain. Cancer 1993; 72: 2266–2272.

Inturisi CE , Portenoy RK , Max MB et al. Pharmacokinetic–pharmacodynamic (PK–PD) relationships of methadone infusions in patients with cancer pain. Clin Pharm Ther 1990; 47: 565–577.