The continuous subcutaneous administration of drugs is both convenient and practical. Portable, battery-driven syringe drivers enable predictable amounts of analgesics or antiemetics to be delivered parenterally. The methods and drugs used are reviewed, including drug compatibility and potential problems.
Wright BM, Callan K.Slow drug infusions using a portable syringe driver. Br Med J1979; ii: 582.
2.
Derlien MLA portable syringe driver: design and applications. J Med Eng Technol1984; 8: 181-83.
3.
Russell Psb.Analgesia in terminal malignant disease. Br Med J1979; i: 1561.
4.
Dickson RJ, Howard B., Campbell J.The relief of pain by subcutaneous infusion of diamorphine. In: Wilkes E, Lenz J eds. Advances in morphine therapy. The 1983 International Symposium on Pain Control Royal Society of Medicine International Symposium Series No. 64. London : Royal Society of Medicine, 1984 : 105-10.
5.
Propper RD, Cooper B., Rufo RR et al. Continuous subcutaneous administration of deferoxamine in patients with iron overload. N Engl J Med1977; 297: 418-23.
6.
Bingle JP, Rutherford JD, Woodrow P.Continuous subcutaneous neostigmine in the management of severe myasthenia gravis. Br Med J1979; i: 1050.
7.
Pughe H.A way to go home. Nursing Mirror1985 ; 160(24): 38-41.
8.
Giles Rowland C, Bradford E.Syringe driver in terminal care . Br Med J1987; 294: 773.
9.
Stibe C., Lees A., Stern G.Subcutaneous infusion of apomorphine and lisuride in the treatment of Parkinsonian on-off fluctuations. Lancet1987; i: 871.
10.
Mecklenburg RS, Benson JW, Becker NM et al. Clinical use of the insulin infusion pump in 100 patients with Type I diabetes. N Engl J Med1982; 307: 513-18.
11.
Berger M., Cupps TR, Fauci ASImmunoglobulin replacement therapy by slow subcutaneous infusion. Ann Intern Med1980; 93: 55-56.
12.
Church JJContinuous narcotic infusions for relief of postoperative pain. Br Med J1979; i: 977-79.
13.
Rutter PC, Murphy F., Dudley Haf.Morphine: controlled trial of different methods of administration for postoperative pain relief. Br Med J1980 ; 280: 12-13.
14.
Adams JD, Diehl LF, Wilson JPAmbulatory use of high-dose intravenous morphine for severe pain. Drug Intell Clin Pharm1984; 18: 138-40.
15.
Wright BMIntramuscular or intravenous antibiotics?Lancet1984; i: 1130.
16.
Regnard C., Newbury A.Pain and the portable syringe pump. Nursing Times1983; 79(26): 25-28.
17.
Dover SBSyringe driver in terminal care. Br Med J1987; 294: 553-55.
18.
Twycross RG , Lack SASymptom control in far advanced cancer: pain relief. London : Pitman, 1983: 215.
19.
Jones VA, Hanks GWNew portable infusion pump for prolonged subcutaneous administration of opioid analgesics in patients with advanced cancer. Br Med J1986; 292: 1496.
20.
Oliver DJThe use of the syringe driver in terminal care. Br J Clin Pharmacol1985; 20: 515-16.
21.
Hutchinson HT, Leedham GD, Knight AMContinuous subcutaneous analgesics and antiemetics in domiciliary terminal care. Lancet1981; ii: 1279.
22.
Campbell CF , Mason JB, Weiler JMContinuous subcutaneous infusion of morphine for the pain of terminal malignancy . Ann Intern Med1983; 98: 51-52.
23.
Nicholson H.The success of the syringe driver. Nursing Times1986; 82(28): 49-51.
24.
Baines M., Oliver DJ, Carter RLMedical management of intestinal obstruction in patients with advanced malignant disease. A clinical and pathological study. Lancet1985; ii: 990-93.
Ventafridda V., Spoldi E., Caraceni A., Tamburini M., De Conno F.The importance of continuous subcutaneous morphine administration for cancer pain control . The Pain Clinic1986; 1: 47-55.
27.
Baines MJCancer pain. Postgrad Med J1984; 60: 852-57.
28.
Jones V., Murphy A., Hanks GWSolubility of diamorphine. Pharmaceutical Journal1985; 235: 426.
29.
Hanks GW, Hoskin PJOpioid analgesics in the management of pain in patients with cancer . A review. Palliative Medicine1987; 1: 1-25.
30.
Miser AW, Davis DM, Hughes CS, Mulne AF, Miser JSContinuous subcutaneous infusion of morphine in children with cancer . Am J Dis Child1983; 137: 383-85.
31.
Annual Statistics 1985. London: St. Christopher's Hospice, 1986.
32.
Oliver DJThe use of methotrimeprazine in terminal care. BrJ Clin Pract1985; 39: 339-40.
33.
Allwood MCDiamorphine mixed with antiemetic drugs in plastic syringes. BrJ Pharm Pract1984; 6: 88-90.
34.
Bray RJ, Davies PA, Seviour JAThe stability of preservative-free morphine in plastic syringes. Anaesthesia1986; 41: 294-95.
Mitrano FP, Baptista RJ, Newton DW, Augustine SCMicrobial contamination potential of solutions in prefilled disposable syringes used with a syringe pump. Am J Hosp Pharm1986; 43: 78-80.
37.
Goudie TA, Allan Mwb, Lonsdale M., Burrow LM, Macrae WA, Grant ISContinuous subcutaneous infusion of morphine for postoperative pain relief . Anaesthesia1985; 40: 1086-92.
38.
Waldmann CS , Eason JR, Rambohul E., Hanson GCSerum morphine levels: a comparison between continuous subcutaneous infusion and continuous intravenous infusion in postoperative patients. Anaesthesia1984; 39: 768-71.
39.
Dickson RJ, Russel Psb.Continuous subcutaneous analgesics for terminal care at home. Lancet1982; i: 165.
40.
Sykes NP, Oliver DJIsotonic methotrimeprazine by continuous infusion in terminal cancer care . Lancet1987; i: 393-94, 522.
