Cyclizine is an antihistamine, which is frequently used to manage nausea and vomiting in cancer patients. Antihistamines can be drugs of misuse/abuse, and the article describes four cancer patients who developed such problems after receiving parenteral cyclizine within the inpatient unit of a cancer centre. The article also briefly reviews the literature on the misuse/abuse of cyclizine and other antihistamines.
1 British National Formulary 53.London: BMJ Publishing Group Ltd & RPS Publishing; 2007.
2.
2 Buckley NA Whyte IM Dawson AH Cruickshank DA . Pheniramine—a much abused drug. Med J Aust1994; 160: 188–192.
3.
3 Dinndorf PA McCabe MA Frierdich S . Risk of abuse of diphenhydramine in children and adolescents with chronic illnesses. J Pediatr1998; 133: 293–295.
4.
4 Bassett KE Schunk JE Crouch BI . Cyclizine abuse by teenagers in Utah. Am J Emerg Med1996; 14: 472–474.
5.
5 Ruben SM McLean PC Melville J . Cyclizine abuse among a group of opiate dependents receiving methadone. Br J Addict1989; 84: 929–934.
6.
6 Hughes GF McElnay JC Hughes CM McKenna P . Abuse/misuse of non-prescription drugs. Pharm World Sci1999; 21: 251–255.
7.
7 Haiart DC Andrade B Murie JA . Gas gangrene following intra-arterial injection of oral medication in a drug abuser. Eur J Vasc Surg1992; 6: 565–566.
8.
8 Gott PH . Cyclizine toxicity—intentional drug abuse of a proprietary antihistamine. New Engl J Med1968; 279: 596.
10 Mannix KA . Palliation of nausea and vomiting. In: D Doyle G Hanks N Cherny K Calman , (eds), Oxford textbook of palliative medicine, 3rd ed.Oxford: Oxford University Press; 2004. p. 459–468.
