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Abstract

Objective

To investigate the effect of sport climbing on a biomechanical marker of axial posture in patients with Parkinson's disease, as well as its association with age, body mass index and health-related quality-of-life outcome measures.

Design

Pre-planned secondary analysis of our randomized controlled, semi-blind trial (unblinded patients, blinded assessors) comparing sport climbing to unsupervised exercise.

Setting

Single-centre study conducted at the Department of Neurology of the Medical University of Vienna, Austria.

Participants

Forty-eight Parkinson's disease patients (aged 64 ± 8 years, Hoehn & Yahr stage 2–3) were included.

Intervention

Sport climbers (n = 24) followed a 12-week, 90 min/week supervised top-rope sport climbing course in an indoor climbing gym. The unsupervised training group (n = 24) independently followed the ‘European Physiotherapy Guidelines for Parkinson's Disease’ and World Health Organization recommendations for an active lifestyle for 12 weeks.

Main measures

Posture was assessed with the horizontal distance of the seventh cervical vertebra to the wall at baseline and after the intervention.

Results

Participating in the sport climbing group significantly predicted the biomechanical marker of axial posture (P = 0.044). The improvement in the biomechanical marker did not affect the quality of life, depression, fatigue, physical activity or fear of falling. Participants in the sport climbing group showed a significantly decreased horizontal distance of the seventh cervical vertebra to the wall after the intervention (−1.7 cm (95%CI [−2.6, −0.8]). In the unsupervised training group, no difference was found (−0.5 cm; 95%CI −1.3, 0.2]).

Conclusions

We conclude that sport climbing improves a biomechanical marker of axial posture in Parkinson's disease.

Keywords

Parkinson's disease posture sport climbing exercise

Introduction

Parkinson's disease is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons. The resulting movement disorder causes not only a combination of bradykinesia, tremor and rigidity but also postural changes. Among the postural changes, a forward-stooped posture with flexion of the cervical and thoracic spine is common.^1,2 Forward stooped posture can cause significant discomfort,³ contributes to an increased risk of falls^4,5 and reduces the quality of life.^3,6–10 Treatment options are limited as postural changes (like other axial symptoms such as postural instability and gait disorders) do not respond well to pharmacological therapy.^1,6,11–13 Deep brain stimulation appears to have some efficacy in stooped posture in small studies,^14,15 but the lack of randomized controlled trials of deep brain stimulation for stooped posture, strict selection criteria, its invasive nature, and its limited availability at specialized centres limit its use for the general patient population.

Among the non-invasive techniques, exercise and physical therapy are widely in use and are among the treatments of choice for Parkinson's disease patients with a stooped posture.¹⁶ Four randomized trials, one controlled trial and two case series have already demonstrated that targeted physical exercise significantly corrects forward postural abnormalities in Parkinson's disease.^17–21 Previous research observed an average improvement of 8°–23° of the forward trunk flexion after 3 or 4 weeks of intervention, respectively. One study reported that eight weeks of aquatic physiotherapy reduced forward neck flexion by 65°.²⁰ Although alternative sports such as yoga and pilates, which provide low-level evidence (owing to the small sample size) on the improvement of posture in healthy controls,^22–25 can have beneficial effects on the cardinal motor symptoms and impaired balance in Parkinson's disease,^26–28 their influence on the stopped posture in Parkinson's disease has not yet been studied. No other study has ever investigated the influence of sport climbing on posture in Parkinson's disease patients specifically.

In our recent randomized controlled trial on sport climbing,²⁹ we proved that sport climbing is a safe, feasible and engaging activity for Parkinson's disease patients and is also highly effective in reducing motor symptoms of Parkinson's disease.²⁹ The sport climbing trial included a pre-planned secondary analysis of the posture. We hypothesized that climbing improves posture due to its holistic effects on the musculoskeletal system: it strengthens the shoulder girdle and trunk muscles, increases hip and shoulder flexibility and forces the patient to recline the head repeatedly and stretch the torso and limbs.^30–33 Additionally, we examine the correlations between posture and non-motor symptoms of Parkinson's disease as well as the influence of age on posture in our cohort, given that forward-stooped posture correlated with age in previous observations.^34–36 We also sought to identify a possible effect of body mass index on the forward-stooped posture in Parkinson's disease, as body weight seemed to influence the posture in a healthy population.³⁷

In summary, effective therapeutic options to improve postural abnormalities in Parkinson's disease are rare. Physical activity is among the most promising option, is widely used, non-invasive and low-risk.^1,6 Sport climbing could counteract postural deformities by increasing upper body strength and flexibility in relevant joints, which is the underlying hypothesis of the study.

Methods

This study is part of the Climb up! Head up! project, which was approved by the ethical committee of the Medical University of Vienna (No. 1774/2012), registered within the US National Library of Medicine (No: NCT04569981) and was performed according to the 1964 Declaration of Helsinki. All subjects provided written informed consent before being included in the trial.

The methods have been published in our recent publication.²⁹ In brief, this was a randomized semi-blind trial (unblinded patients, blinded assessors) of 12 weeks duration, investigating an intervention group, ‘sport climbing group’ and a control group, ‘unsupervised training group’. Using a table-generated permuted block randomization approach, we randomized the patients to one of two groups of equal sample size.³⁸ Sport climbers followed a 12-week, 90 min/week supervised top-rope sport climbing course in an indoor climbing gym, with an instructor-to-patient ratio of 1: 3-4. Only certified climbing trainers served as instructors. The participants received lessons in top-rope climbing, the most common style at indoor climbing walls. Top-rope climbing involves a ‘belayer’, that is, a person standing on the ground securing the rope holding the climber.²⁹ The participants were actively engaged throughout the whole 90 min, either as climbers or as belayers.

The unsupervised training group independently followed the ‘European Physiotherapy Guidelines for Parkinson's Disease’ and World Health Organization recommendations for an active lifestyle for 12 weeks.^16,39 The recommendations advise patients to perform moderate aerobic physical activities for 150 min/per week, strength training twice a week and balance exercises three times per week.^39,40 We instructed the patients to complete a training log and performed telephonic follow-up calls every 7–10 days. We discouraged changes in dopaminergic medication and deep brain stimulation settings throughout the study period wherever possible without compromising the patient's well-being; however, changes in both medication and DBS settings were allowed and did not constitute an exclusion criterion if they occurred during the study period.

We included patients with mild to moderate idiopathic Parkinson's disease (Hoehn & Yahr stage 2-3), diagnosed according to the UK Brain Bank criteria without prior climbing experience and recruited them between June 2018 and May 2019 from the Medical University of Vienna Movement Disorders Clinic. Patients were deemed ineligible for the trial if they had a history of stroke, severe orthopaedic problems, severe visual or hearing problems and significant cognitive impairment (Mini-Mental State Examination score <24).

The pre-specified secondary analysis examines the effect of sport climbing versus unsupervised physical exercise on posture and the association of posture with body mass index, age and non-motor symptoms of Parkinson's disease. All raters performing the clinical evaluation were blinded to the patient's group allocations. All assessments at baseline and after 12 weeks at the end of the intervention were performed in the patients’ best ON-state.

Analysis of the postural assessment was pre-specified as part of the sport climbing trial. The horizontal distance of the seventh cervical vertebra to the wall was measured using a digital caliper (Preciva 150 mm, measurement accuracy 0.01 mm). For this purpose, participants were instructed to stand upright with their back, sacrum and heels against a wall (see Figure 1).

Figure 1.

Definition of the C7 sagittal vertical axis. The C7 sagittal vertical axis (C7SVA) is defined as the horizontal distance of the seventh cervical vertebra (C7) to the wall. We measured the horizontal distance between the C7 and the wall using a digital caliper.

This test is a simple but highly reliable method to analyze posture in Parkinson's disease patients without the influence of a potentially confounding head position.

The motor symptoms of Parkinson's disease were assessed with the Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale part III (including axial rigidity, posture, and postural stability) and the Hoehn & Yahr stage.

Health-related quality-of-life outcome measures were assessed at baseline and the endpoint with the following questionnaires: quality of life with the Parkinson's Disease Questionnaire,⁴¹ depression with the Beck Depression Inventory,⁴² fatigue with the Parkinson's Fatigue Scale,⁴³ physical activity with the Physical Activity Scale for the Elderly⁴⁴, and fear of falling with the Falls Self-Efficacy Scale. Body mass index was calculated using the usual formula of dividing the patient's weight by their height in metres squared.

The horizontal distance of the seventh cervical vertebra to the wall at baseline and after 12 weeks was compared by group (sport climbing vs. unsupervised training). We then separately calculated absolute mean differences for each group between baseline and after 12 weeks with robust 95% confidence intervals. We formally tested for the influence of the group assignment on the horizontal distance of the seventh cervical vertebra to the wall using a linear regression model. The mean score of the horizontal distance of the seventh cervical vertebra to the wall after 12 weeks served as the dependent variable and the assignment to the intervention group as an indicator-covariate. We report both coefficients and P-values derived from the t-statistic of the covariate. Influencing factors on the posture were analyzed using multivariable logistic regression. A two-sided P-value below 0.05 was considered statistically significant. We used STATA 16 (Stata Corp, College Station, TX) for all analyses.⁴⁵

Sample size considerations were based on the effect of the intervention on the absolute difference in the horizontal distance of the seventh cervical vertebra to the wall before and after 12 weeks. We expected no effect (absolute difference of 0 cm) within the control group,¹⁹ with a standard deviation of 2 cm, based on previous experience. No previously published data was available on the estimated effect in the intervention group.

The available sample size of 48 subjects (24 per group) would show an effect of at least d = 0.73 with a power of 0.8 based on a probability of error of the first kind of 0.05. Given the aforementioned expected characteristics of the control group, this effect size corresponds to an absolute difference of at least 1.4 cm or larger for the intervention group.

Results

Forty-eight patients were included in the study. Of those, 46 were included in the analysis due to two dropouts in the sport climbing group (one due to unrelated health reasons and one due to a loss of interest in the study). The baseline characteristics are summarized in Table 1.

Table 1.

Patient characteristics.

	SC	(n = 22)	UT	(n = 24)
Age, mean (SD; range)	64	(8.1; 45–78)	64	(8.5; 49–78)
Female sex, n (%)	9	(41)	8	(33)
Disease duration, years since diagnosis (range)	7	(2–15)	5	(0–12)
Hoehn and Yahr stage, n (%)
2	18	(82)	22	(92)
3	4	(18)	2	(8)
MDS-UPDRS-III score at baseline, mean (SD)	37.5	(10.9)	34.2	(14.2)
Patients without dopaminergic therapy, n (%)	0	(0)	1	(4)
LEDD, mg, mean (SD; range)	553	(289; 200–1464)	583	(373; 0–1365)
Patients with deep brain stimulation, n (%)	1	(4)	1	(4)
Mini Mental State Examination score, mean (SD)	29.4	(0.7)	29.2	(1.3)

SD: standard deviation; SC: sport climbing group; UT: unsupervised training group; Hoehn and Yahr stage (score 0–5); MDS-UPDRS-III: motor part of the Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (score 0–132; higher scores indicate worse functioning); LEDD: levodopa equivalent daily dose; Mini-Mental State Examination (score 0–30; lower scores indicate worse functioning). Data are mean (SD, range, percentage) unless indicated otherwise.

We achieved well-matched groups concerning baseline characteristics (see Table 1). With 99% course participation, adherence to the intervention was extremely high. We observed no adverse events during the study period, either in the sport climbing group or in the unsupervised training group.

At baseline, the mean horizontal distance of the seventh cervical vertebra to the wall did not significantly differ between the two groups (sport climbing group: 8.2 cm, 95%CI [7.3, 9.2], unsupervised training group: 7.7 cm; 95%CI [6.8, 8.6], mean difference 0.5 cm, 95%CI [−0.7, 1.8]).

According to the regression model, the change in the horizontal distance of the seventh cervical vertebra to the wall over 12 weeks was significantly associated with being part of the sport climbing group versus the unsupervised training group (coeff. 1.2; P = 0.044). This effect remained statistically significant when controlling for body mass index and age (coeff. 1.2; P = 0.048).

None of the health-related quality-of-life outcome scores (Parkinson's Disease Questionnaire, Beck Depression Inventory, Parkinson's Fatigue Scale, Physical Activity Scale for the Elderly, Falls Self-Efficacy Scale) were significantly associated with a change in the horizontal distance of the seventh cervical vertebra to the wall, neither in the intervention nor in the control group.

Within a period of 12 weeks, there was a significant improvement in the horizontal distance of the seventh cervical vertebra to the wall in the sport climbing group (−1.7 cm (95%CI [−2.6, −0.8]), but not in the unsupervised training group (−0.5 cm; 95%CI [−1.3, 0.2]; Table 2 and Figure 2).

Figure 2.

The effect of sport climbing on posture in Parkinson's disease. Boxplot of the horizontal distance of the seventh cervical vertebra (C7) to the wall (C7SVA) according to groups. Within each box, a vertical line indicates the median value; boxes range from the 25th to the 75th percentile of the value distribution of each group (interquartile range); horizontal lines indicate the minimum and maximum values, respectively. The figure shows the effect of climbing on the C7SVA at baseline and after 12 weeks compared to unsupervised physical training. Climbing significantly reduced the C7SVA after 12 weeks, while unsupervised physical training did not. SC, sport climbing group (green); UT, unsupervised physical training group (gray); C7SVA: C7 sagittal vertical axis distance; level of significance: *P < 0.05.

Table 2.

Outcome.

C7SVA (cm)	Baseline		END		Change from baseline
	Mean (SD)	95%CI	Mean (SD)	95%CI	Mean (SD)	95%CI
SC (n = 22)	8.2 (2.2)	7.3–9.2	6.5 (1.8)	5.7 to −7.3	−1.7 (2.0)	−2.6 to −0.8
UT (n = 22)	7.7 (2.1)	6.8–8.6	7.2 (2.5)	6.1 to 8.2	−0.5 (1.9)	−1.3 to 0.3

Data are mean (SD) and 95% of confidence interval (95% CI). END, visit after 12 weeks of intervention (=end of trial); SC: sport climbing group; UT: unsupervised physical training group; C7SVA: seventh cervical vertebra sagittal vertical axis, the horizontal distance of the seventh cervical vertebra to the wall; SD: standard deviation.

Discussion

In this secondary analysis of a randomized trial, we investigated the effect of sport climbing on the stooped posture of Parkinson's disease patients and demonstrated that sport climbing can potentially decrease the forward flexion of the cervical spine in PD patients. Posture improvement was observed in Parkinson's disease patients regardless of age or body mass index. The improvement of this biomechanical measure was not associated with an improvement of quality-of-life outcome measures.

Although we did not directly compare sport climbing to other sports in our study, we found similarities in previous observations that posture-specific physical therapy is a reliable method to improve postural symptoms of Parkinson's disease.^17–20

Why does sport climbing improve posture in Parkinson's disease? The stooped posture found in Parkinson's disease is most often not a fixed deformity and is, therefore, amenable to corrective exercises.⁴⁶ The strengthening effect sport climbing has on the back and shoulder girdle muscles^{31,33,47–51} may enable the patient to yield a more upright posture.^17,21

Another explanation for the effectiveness of sport climbing for Parkinson's disease could be found in the fact that sport climbing improves flexibility in the trunk and spine.^31,48

With its high demands on movement planning and execution, climbing also trains spatial body awareness, a crucial component of maintaining and correcting posture.^1,34,52 Proprioception is considered an essential element for neuromotor control of the upper body, and its improvement by visual or tactile feedback training is associated with a reduction in forward bent posture in Parkinson's disease.^{17–19,46,53}

Rigidity is one of the contributing factors to postural abnormalities,¹ and Parkinson's disease patients with a bradykinetic-rigid type suffer from postural abnormalities more often than patients with a tremor-dominant type.¹⁰ We have demonstrated that sport climbing reduces rigidity by 30% after 12 weeks;²⁹ a finding that indicates another possible therapeutic effect of climbing on postural abnormalities.

In our study, the improvement in the biomechanical postural marker did not affect the subjective sensation of postural safety in the Falls Efficacy Scale. Stooped posture does influence postural stability by partially reducing stabilizing postural reflexes^4,54; an improvement of stooped posture could, therefore, potentially improve postural stability. However, a forward bending posture is also used as a preventative stance to protect against falls.⁴ This could explain why a more upright stance did not decrease the participants’ fear of falling.

Because the C7SVA is a biomechanical measure that does not always affect patients’ subjective symptoms or quality of life, the conclusions that can be drawn from this study may be somewhat limited. The analysis could not be completed on all patients because of two dropouts, one due to a loss of interest in the intervention. This study did not record long-term results after the climbing training. The relatively small sample size of our study could limit its power. As with all studies on active interventions, a self-selection bias or participation might have occurred via the recruiting process, not only favouring patients with high intrinsic motivation but also means of participating in the study (i.e., transportation to and from the climbing hall and advantageous geographical location).

In summary, sport climbing improves forward-stooped posture in mild to moderate Parkinson's disease. A variety of mechanisms, including increased trunk muscle strength, stretching of shortened muscles, improvement of proprioception, and cognitive effects, may contribute to this effect.

Clinical messages

Sport climbing improves a biomechanical measure of posture in mild to moderately affected Parkinson's disease patients.

Footnotes

Acknowledgements

The authors want to express our sincere gratitude to all patients and climbing instructors of the Climbing Center’ Climb on Marswiese’ to support this project's enthusiastic participation and support. The authors would also like to thank the private donors who made the project possible and the Hilde-Ulrichs-Foundation for Parkinson's Research, Germany. LG was endorsed by the Marietta Blau grant from the Austrian Federal Ministry of Science and Research and the City of Vienna's scholarship. Finally, the authors would like to thank Mr Albert Robwein, MA, for his proofreading and language editing efforts.

Data availability statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Declaration of conflicting interests

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Funding

The author(s) received no financial support for the research, authorship, and/or publication of this article.

ORCID iDs

Agnes Langer

Jakob Gruber

Lucia Gassner

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Climb up! Head up! Climbing improves posture in Parkinson's disease. A secondary analysis from a randomized controlled trial

Abstract

Objective

Design

Setting

Participants

Intervention

Main measures

Results

Conclusions

Keywords

Introduction

Methods

Results

Discussion

Clinical messages

Footnotes

Acknowledgements

Data availability statement

Declaration of conflicting interests

Funding

ORCID iDs

References