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Abstract

Objective:

To evaluate the effectiveness of a cognitive behavioral group-based intervention aimed at reducing depression and fostering quality of life and psychological well-being of multiple sclerosis patients through the promotion of identity redefinition, sense of coherence, and self-efficacy.

Design:

A randomized controlled trial.

Setting:

Non-medical setting, external to the Multiple Sclerosis Clinic Centre.

Subjects

Eighty-two patients: 64% women; mean age 40.5, SD = 9.4; 95% with relapsing-remitting multiple sclerosis; Expanded Disability Status Scale (EDSS) between 1 and 5.5 were included in the study.

Interventions:

Patients were randomly assigned to an intervention group (five cognitive behavioral group-based sessions, n = 41) or to a control group (three informative sessions, n = 41).

Main measures

Depression (CES-D), Quality of life (MSQOL revised), Psychological well-being (PANAS), Identity Motives Scale, Sense of Coherence (SOC), and Self Efficacy in Multiple Sclerosis.

Results

Quality of life increased in the intervention group compared with the control at 6-months follow-up (mean change 0.72 vs. −1.76, p < 0.05). Well-being in the intervention group increased for males and slightly decreased for females at 6-months follow-up (mean change 6.58 vs. −0.82, p < 0.05). Contrasts revealed an increase in self-efficacy in the intervention group at posttreatment compared with the control (mean change 2.95 vs. −0.11, p < 0.05). Depression tended to lower, while identity and coherence increased in the intervention group compared with the control, though the differences were not significant.

Conclusions:

Preliminary evidence suggests that intervention promotes patients’ quality of life and has an effect on psychological well-being and self-efficacy.

Keywords

Multiple sclerosis cognitive behavioral therapy group therapy identity sense of coherence self-efficacy quality of life depression well-being

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