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Abstract

Objective:

The purpose of this study was to determine if there is a practice effect present in the timed 25-foot walk in ambulatory individuals with multiple sclerosis.

Design:

Thirty six people (30 women and 6 men) diagnosed with relapsing remitting multiple sclerosis participated in two testing sessions, one week apart. Each participant performed two sequential trials of the timed 25-foot walk test per session and the walk performance was measured with a laser timing system.

Results:

We observed improvements in walking speed between the two trials of session one (trial one: 6.42 (0.09) vs. trail two: 5.97 (0.08) seconds, p < 0.001). Within session two, performance remained stable (trial three: 5.71 (0.07) vs. trial four: 5.63 (0.07) seconds, p > 0.05). We also observed a significant improvement in walking speed when averages of the two trials were compared across sessions (session 1: 6.19 (0.09) vs. session 2: 5.67 (0.07) seconds, p < 0.01).

Conclusions:

Based on our results, familiarization of the timed 25-foot walk test improves stability of walk performance scores in ambulatory individuals with relapsing remitting multiple sclerosis.

Keywords

Multiple sclerosis assessment clinical tests mobility repeatability

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References

Kurtzke

. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983; 33(11): 1444–1452.

Noseworthy

. Clinical scoring methods for multiple sclerosis. Ann Neurol 1994; 36 Suppl: S80–85.

Hobart

Freeman

Thompson

. Kurtzke scales revisited: the application of psychometric methods to clinical intuition. Brain 2000; 123(Pt 5): 1027–1040.

Sharrack

Hughes

Soudain

Dunn

. The psychometric properties of clinical rating scales used in multiple sclerosis. Brain 1999; 122(Pt 1): 141–159.

Whitaker

McFarland

Rudge

Reingold

. Outcomes assessment in multiple sclerosis clinical trials: a critical analysis. Mult Scler 1995; 1(1): 37–47.

Kaufman

Moyer

Norton

. The significant change for the Timed 25-foot Walk in the multiple sclerosis functional composite. Mult Scler 2000; 6(4): 286–290.

Rudick

Antel

Confavreux

. Recommendations from the National Multiple Sclerosis Society Clinical Outcomes Assessment Task Force. Ann Neurol 1997; 42(3): 379–382.

Rudick

Antel

Confavreux

. Clinical outcomes assessment in multiple sclerosis. Ann Neurol 1996; 40(3): 469–479.

Fischer

Rudick

Cutter

Reingold

. The Multiple Sclerosis Functional Composite Measure (MSFC): an integrated approach to MS clinical outcome assessment. National MS Society Clinical Outcomes Assessment Task Force. Mult Scler 1999; 5(4): 244–250.

10.

Cutter

Baier

Rudick

. Development of a multiple sclerosis functional composite as a clinical trial outcome measure. Brain 1999; 122(Pt 5): 871–882.

11.

Cohen

Cutter

Fischer

. Use of the multiple sclerosis functional composite as an outcome measure in a phase 3 clinical trial. Arch Neurol 2001; 58(6): 961–967.

12.

Soilu-Hanninen

Aivo

Lindstrom

. A randomised, double blind, placebo controlled trial with vitamin D3 as an add on treatment to interferon beta-1b in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry 2012; 83(5): 565–571.

13.

Spain

St George

Salarian

. Body-worn motion sensors detect balance and gait deficits in people with multiple sclerosis who have normal walking speed. Gait Posture 2012; 35(4): 573–578.

14.

Gijbels

Dalgas

Romberg

. Which walking capacity tests to use in multiple sclerosis? A multicentre study providing the basis for a core set. Mult Scler 2012; 18(3): 364–371.

15.

Broekmans

Roelants

Feys

. Effects of long-term resistance training and simultaneous electro-stimulation on muscle strength and functional mobility in multiple sclerosis. Mult Scler 2011; 17(4): 468–477.

16.

Bosma

Kragt

Knol

Polman

Uitdehaag

. Clinical scales in progressive MS: predicting long-term disability. Mult Scler 2012; 18(3): 345–350.

17.

Phan-Ba

Pace

Calay

. Comparison of the timed 25-foot and the 100-meter walk as performance measures in multiple sclerosis. Neurorehabil Neural Repair 2011; 25(7): 672–679.

18.

Ratchford

Shore

Hammond

. A pilot study of functional electrical stimulation cycling in progressive multiple sclerosis. Neuro Rehabilitation 2010; 27(2): 121–128.

19.

Widener

Allen

Gibson-Horn

. Balance-based torso-weighting may enhance balance in persons with multiple sclerosis: preliminary evidence. Arch Phys Med Rehabil 2009; 90(4): 602–609.

20.

Sutliff

Naft

Stough

Lee

Arrigain

Bethoux

. Efficacy and safety of a hip flexion assist orthosis in ambulatory multiple sclerosis patients. Arch Phys Med Rehabil 2008; 89(8): 1611–1617.

21.

Ytterberg

Johansson

Andersson

Widen Holmqvist

von Koch

. Variations in functioning and disability in multiple sclerosis. A two-year prospective study. J Neurol 2008; 255(7): 967–973.

22.

Solari

Radice

Manneschi

Motti

Montanari

. The multiple sclerosis functional composite: different practice effects in the three test components. J Neurol Sci 2005; 228(1): 71–74.

23.

Schwid

Goodman

McDermott

Bever

Cook

. Quantitative functional measures in MS: what is a reliable change? Neurology 2002; 58(8): 1294–1296.

24.

Rudick

Cutter

Reingold

. The multiple sclerosis functional composite: a new clinical outcome measure for multiple sderosis trials. Mult Scler 2002; 8(5): 359–365.

25.

Rosti-Otajarvi

Hamalainen

Koivisto

Hokkanen

. The reliability of the MSFC and its components. Acta Neurol Scand 2008; 117(6): 421–427.

Repeatability of the timed 25-foot walk test for individuals with multiple sclerosis

Abstract

Objective:

Design:

Results:

Conclusions:

Keywords

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References