Objective: The purpose of this study was to compare adaptations in
functional and quality of life measures following endurance- and resistance-exercise
training in people with multiple sclerosis.
Design: Cross-over design with an eight-week washout period.
Setting: Community health centre.
Subjects: Sixteen individuals with multiple sclerosis.
Intervention: Subjects completed both an eight-week endurance- and an
eight-week resistance-exercise training programme in a randomized order. The exercise
training comprised individualized progressive programmes that were completed twice
weekly in a supervised group setting.
Main measures: Grip strength, functional reach, four step square, timed
up and go and six-minute walk tests, Multiple Sclerosis Impact and Modified Fatigue
Impact Scales, Becks Depression Inventory and the Health Status Questionnaire Short
Form-36.
Results: Sixteen of 21 (76%) subjects completed the study. Subjects
attended 13.2 ± 1.6 endurance- and 15.8 ± 1.9 resistance-exercise training sessions.
No adverse events were reported. No significant differences
(P < 0.05) in any outcome measures were observed between the two
exercise training programmes either at baseline or following the completion of both
training programmes.
Conclusion: Both endurance- and resistance-exercise training were well
tolerated and appear to provide similar effects for people with multiple sclerosis,
but larger studies are required to confirm these findings.
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