Control of Lymphatic Pumping: Interest of Daflon 500 mg

Abstract

Objective:

To determine the effects of Daflon 500 mg on lymph flow, known to be modulated by lymph formation and contractility of the collecting ducts.

Experimental design:

The effect of Daflon 500 mg was investigated in vitro on isolated rings of sheep mesenteric lymphatics, at concentrations of 10^-7 M and higher. In vivo, lymph flow was measured in unanaesthetized sheep before and after 5 days of administration of Daflon 500 mg at the oral dose of 10 mg/kg/day.

Results:

Daflon 500 mg significantly increased the frequency of spontaneous contractions in vitro, and in vivo increased the lymph flow when compared with pre-drug levels.

Conclusion:

It is suggested that Daflon 500 mg increases lymph flow under these conditions by stimulating the lymph pump directly, a result that is consistent with previous studies.