To evaluate Indium-111 antifibrin monoclonal antibody in the diagnosis of deep vein thrombosis.
Design:
Prospective study in twelve patients undergoing major surgical treatment, including hip surgery, who would be considered at high risk of developing subsequent deep vein thrombosis.
Setting:
Departments of Angiology and Vascular Surgery, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Patients:
Twelve patients receiving surgical treatment.
Interventions:
Bilateral contrast phlebography was performed in all patients, combined with an ***immunoscintigraphic test of an Indium-111 labelled monoclonal ***antibody to fibrin. Patients with deep vein thrombosis were treated with full anticoagulation using heparin.
Main outcome measures:
The presence of thrombosis on phlebography and the presence of isotopic labelling of suspected deep vein thrombosis on immunoscintigraphic scanning.
Results:
Phlebography demonstrated venous thrombosis at 23 sites in veins, of which 22 were also detected by immunoscintigraphic scanning.
Conclusions:
Indium-111 labelled monoclonal antibodies to fibrin may provide an alternative method of investigation for suspected deep vein thrombosis as an alternative to other non-invasive diagnosis methodologies.
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