To investigate the use of high intensity focused ultrasound (HIFU) for great saphenous vein (GSV) incompetence.
Material and methods
Patients with GSV incompetence underwent HIFU. The primary endpoint was the rate of GSV target segment shrinkage or closure after 1 year.
Results
Out of 188 limbs treated, the GSV treated segment shrinkage/closure rate at 1 week, 3 months, 6 months, and 12 months was 93.3%, 98.2%, 97.6%, and 98.3%, respectively.
Conclusion
These preliminary results suggest that HIFU holds promise for the treatment of GSV incompetence. Further trials are needed to compare it with other techniques and assess long-term outcomes.
CuriePCurieJ. Développement, par pression, de électricité polaire dans les cristaux hémièdres à faces inclinées. Académie des sciences (France) Comptes rendus hebdomadaires des séances de l’Académie des sciences1880; 91: 294–295.
2.
ChilowskiCLangevinPinventors. Production of submarine signals and the location of submarine objects. Montgomery: Hatton Press, 1923.
3.
PhenixCPTogtemaMPichardoS, et al.High intensity focused ultrasound technology, its scope and applications in therapy and drug delivery. J Pharm Pharmaceut Sci2014; 17(1): 136–153.
4.
BachuVSKeddaJSukI, et al.High-intensity focused ultrasound: a Review of mechanisms and clinical applications. Ann Biomed Eng2021; 49(9): 1975–1991.
5.
QuadriSAWaqasMKhanI, et al.High-intensity focused ultrasound: past, present, and future in neurosurgery. Neurosurg Focus2018; 44(2): E16.
6.
Cavallo MarincolaBPediconiFAnzideiM, et al.High-intensity focused ultrasound in breast pathology: non-invasive treatment of benign and malignant lesions. Expet Rev Med Dev2015; 12(2): 191–199.
7.
BachuVSKeddaJSukI, et al.High-intensity focused ultrasound: a Review of mechanisms and clinical applications. Ann Biomed Eng2021; 49(9): 1975–1991.
8.
KhandwalaYSSoerensenSJCMorisettyS, et al.The association of tissue change and treatment success during high-intensity focused ultrasound focal therapy for prostate cancer. Eur Urol Focus2023; 9(4): 584–591.
9.
Schultz-HaakhHLiJKWelkowitzW, et al.Ultrasonic treatment of varicose veins. Angiology1989; 40(2): 129–137.
10.
ObermayerAAubryJFBarnatN. Extracorporeal treatment with high intensity focused ultrasound of an incompetent perforating vein in a patient with active venous ulcers. EJVES Vasc Forum2020; 50: 1–5.
11.
WhiteleyMS. High intensity focused ultrasound (HIFU) for the treatment of varicose veins and venous leg ulcers - a new non-invasive procedure and a potentially disruptive technology. Curr Med Res Opin2020; 36(3): 509–512.
12.
ObermayerASteinbacherF. First experience with Sonovein HD. J Vasc Surg Venous Lymphat Disord2023; 11(2): P466.
13.
von ElmEAltmanDGEggerM, et al.The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Epidemiology2007; 18: 800e4.
14.
PerrinMEklofBVan RijA, et al.Venous symptoms: the SYM vein consensus statement developed under the auspices of the European venous forum. Int Angiol2016; 35(4): 374–398.
15.
De MaeseneerMGKakkosSKAherneT, et al.European society for vascular surgery (ESVS) 2022 clinical practice guidelines on the management of chronic venous disease of the lower limbs. Eur J Vasc Endovasc Surg2022; 63(2): 184–267.
16.
MarstonWAVasquezMALurieF, et al.Multicenter assessment of the repeatability and reproducibility of the revised Venous Clinical Severity Score (rVCSS). J Vasc Surg Venous Lymphat Disord2013; 1(3): 219–224.
17.
LaunoisRMansilhaALozanoF. Linguistic validation of the 20 item-chronic venous disease quality-of-life questionnaire (CIVIQ-20). Phlebology2014; 29(7): 484–487.
18.
WongMParsiKMyersK, et al.Sclerotherapy of lower limb veins: indications, contraindications and treatment strategies to prevent complications - a consensus document of the International Union of Phlebology-2023. Phlebology2023; 38(4): 205–258.
19.
CasoniPNanniEPizzamiglioM, et al.Varicotape: temporary selective varices compression. JTAVR2023; 08(1): 27–31.
20.
LeeBBNicolaidesANMyersK, et al.Venous hemodynamic changes in lower limb venous disease: the UIP consensus according to scientific evidence. Int Angiol2016; 35(3): 236–352.
21.
FranceschiCCappelliMErminiS, et al.CHIVA: hemodynamic concept, strategy and results. Int Angiol2016; 35(1): 8–30.
22.
PittalugaPChastanetSLocretT, et al.The effect of isolated phlebectomy on reflux and diameter of the great saphenous vein: a prospective study. Eur J Vasc Endovasc Surg2010; 40(1): 122–128.
23.
BissaccoDStegherSCalliariFM, et al.Avoiding aesthetic complications after endovenous radiofrequency ablation. Phlebologie2017; 46(5): 278–280.
24.
BarnatNGriseyAGeroldB, et al.Vein wall shrinkage induced by thermal coagulation with high-intensity-focused ultrasound: numerical modeling and in vivo experiments in sheep. Int J Hyperther2020; 37(1): 1238–1247.
25.
BarnatNGriseyAGeroldB, et al.Efficacy and safety assessment of an ultrasound-based thermal treatment of varicose veins in a sheep model. Int J Hyperther2020; 37(1): 231–244.
26.
BissaccoDStegherSCalliariF, et al.Relationship between great saphenous vein recanalization, venous symptoms reappearance, and varicose veins recurrence rates after endovenous radiofrequency ablation. Phlebology2022; 37(9): 686–688.
