The effect of high dose aprotinin therapy on the systemic inflammatory response in a porcine model of cardiopulmonary bypass

Wachtfogel YT , Kucich U. , Greenplate J. et al. Human neutrophil degranulation during extracorporeal circulation. Blood 1987; 69: 324-30.

Gnanadurai TV , Branthwaite MA , Colbeck JF , Welman E. Lysosomal enzyme release during cardiopulmonary bypass. Anaesthesia 1977; 32: 743-48.

Bolanowski PJ , Bauer J. , Machiedo G. , Neville WE Prostaglandin influence on pulmonary intravascular leukocytic aggregation during cardiopulmonary bypass. J Thorac Cardiovasc Surg 1977; 73: 221-24.

Wachtfogel YT , DeLa Cadena RA, Colman RW. Structural biology, cellular interactions and pathophysiology of the contact system. Thromb Res 1993; 72: 1-21.

Wachtfogel YT , Harpel PC , Edmunds LH Jr, Colman RW Formation of C1s-C1-inhibitor, kallikrein-Cl-inhibitor, and plasmin-alpha 2-plasmin-inhibitor complexes during cardiopulmonary bypass . Blood 1989; 73: 468-71.

Katz W. , Mammen EF , Thal AP Inhibition of fibrinolysis during extracorporeal circulation. Surg Forum 1965; 16: 63-64.

Nagaoka H. , Innami R. , Murayama F. et al. Effects of aprotinin on prostaglandin metabolism and platelet function in open heart surgery. J Cardiovasc Surg Torino 1991; 32: 31-37.

Lu H. , Soria C. , Commin PL et al. Hemostasis in patients undergoing extracorporeal circulation: the effect of aprotinin (Trasylol). Thromb Haemost 1991; 66: 633-37.

de Smet AA , Joen MC , van Oeveren W. et al. Increased anticoagulation during cardiopulmonary bypass by aprotinin . J Thorac Cardiovasc Surg 1990; 100: 520-27.

Dietrich W. , Spannagl M. , Jochum M. et al. Influence of high-dose aprotinin treatment on blood loss and coagulation patterns in patients undergoing myocardial revascularization Anesthesiology 1990; 73: 1119-26.

Blauhut B. , Gross C. , Necek S. , Doran JE , Spath P. , Lundsgaard Hansen P. Effects of high-dose aprotinin on blood loss, platelet function, fibrinolysis, complement, and renal function after cardiopulmonary bypass J Thorac Cardiovasc Surg 1991; 101: 958-67.

Nagaoka H. , Katori M. Inhibition of kinin formation by a kallikrein inhibitor during extracorporeal circulation in open-heart surgery. Circulation 1975; 52: 325-32.

van Oeveren W. , Jansen NJ , Bidstrup BP et al. Effects of aprotinin on hemostatic mechanisms during cardiopulmonary bypass. Ann Thorac Surg 1987; 44: 640-45.

Wachtfogel YT , Kucich U. , Hack CE et al. Aprotinin inhibits the contact, neutrophil, and platelet activation systems during simulated extracorporeal perfusion . J Thorac Cardiovasc Surg 1993; 106: 1-9; discussion 9-10.