Use of aprotinin in lung transplantation

Abstract

Although the use of aprotinin has been well documented for cardiac surgical procedures, its use in lung transplantation has received less attention. Herein is the experience at Washington University with aprotinin in patients undergoing lung transplantation (most with cystic fibrosis). In these patients, bleeding from the chest wall is a major problem due to the dense adhesions from chronic infection. Aprotinin has a dramatic effect in reducing bleeding.