The effects of aortic crossclamp time, myocardial incision size and location, bypass time and hypothermia were investigated with respect to perioperative enzyme changes; CPK, CPK-MB and LDH, in 40 patients undergoing a variety of open-heart procedures for acquired and congenital heart disease. This study indicates that, with the exception of CPK-MB, these enzyme levels returned to normal by the seventh postoperative day and that there are significant differences in elevations relative to crossclamp time, size and location of the myocardial incision, but not to bypass time or hypothermia.
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