The use of hyperthermic isolated limb perfusion in conjunction with antiblastic drugs is finding ever wider applications in the treatment of malignancies localised in the extremities. The basic technique was described nearly 30 years ago,' but recent refinements in surgical technique, perfusion and cytotoxic therapy have brought about very encouraging results. The technique described outlines particular considerations with respect to effective limb isolation, temperature control, perfusion control and measures required to limit the systemic toxic side effects of the drugs used.
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