Cholesterol, apolipoproteins A1 and B and triglycerides were evaluated before, during and after extracorporeal circulation during cardiac surgery to a precise degree and chronology of variations. Cholesterol, apolipoprotein B and triglycerides show a significant and persistent decrease following initiation of extracorporeal circulation. Triglycerides decrease is due to factors such as heparin administration. Cholesterol and apolipoprotein B decrease does not appear to be due either to contact with extracorporeal circulation circuit nor hypothermia. Decrease of hepatic VLDL and HDL production or modifications of LDL-cholesterol cell clearance are possible explanations.
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References
1.
WatsonWCBuchananKDDicksonC. Serum cholesterol levels after myocardial infarction. Br Med J1969; 2: 709.
2.
RonnemaaTViikariJIrjalaKPeltolaO. Marked decrease in serum HDL cholesterol level during acute myocardial infarction. Acta Med Scand1980; 207 (3): 161–66.
WahlefeldAW. Triglycerides determinations after enzymatic hydrolysis. In: BergmeyerHV ed. Methods of enzymatic analysis. Third editiorAcademic Press, 1985: 2–12.
5.
FruchartJCDuthilleulPKoraIDuquesneMClaveyVGentiliniL. Rapid determination of human plasma apolipoprotein B. Clin Chim Acta1981; 114 (1): 123–26.
6.
WernerM. Serum protein changes during the acute phase reaction. Clin Chim Acta1969; 25: 299–305.
7.
OliverMF. Why measure cholesterol after myocardial infarction, and when?Br Med J1984; 289: 1641–42.
8.
de la FargeFLagenteMBarthelemyRThe biochemical performance of several oxygenators used regularly in extracorporeal circulation. Ann Biol Clin1982; 40: 443.
