Restricted accessLetterFirst published online 2025-7
All models are wrong but some provide seemingly surprising mechanistic insights into the complexity of venoarterial extracorporeal membrane oxygenation
BeurtonAImbaultJOuattaraA. Comments on the Article “Physiology of Venoarterial Extracorporeal Membrane Oxygenation” by Fresiello et al. Perfusion. 2024.
2.
BrooméMDonkerDW. Individualized real-time clinical decision support to monitor cardiac loading during venoarterial ECMO. J Transl Med2016; 14: 4. DOI: 10.1186/s12967-015-0760-1.
3.
DonkerDWMeuweseCLBraithwaiteSA, et al.Echocardiography in extracorporeal life support: a key player in procedural guidance, tailoring and monitoring. Perfusion2018; 33(1_suppl): 31–41. DOI: 10.1177/0267659118766438.
4.
LiewSNanayakkaraSSheldrakeJ, et al.Venoarterial ECMO reduces left ventricular dimensions in patients with cardiogenic shock. J Am Coll Cardiol2018; 71(11_Supplement): A751.
5.
KalraRYannopoulosDBartosJA. Left ventricular unloading during VA-ECMO: a Gordian knot of physiology. Resuscitation2024; 195: 110122. DOI: 10.1016/j.resuscitation.2024.110122.
6.
KalraRAlexyTBartosJA, et al.Left ventricular hemodynamics with veno-arterial extracorporeal membrane oxygenation. Cathet Cardiovasc Interv2024; 103(3): 472–481. DOI: 10.1002/ccd.30951.
7.
FresielloLHermensJAJPladetL, et al.The physiology of venoarterial extracorporeal membrane oxygenation - a comprehensive clinical perspective. Perfusion2024; 39(1_suppl): 5S–12S. DOI: 10.1177/02676591241237639.
8.
DonkerDWBrodieDHenriquesJPS, et al.Left ventricular unloading during veno-arterial ECMO: a simulation study. Am Soc Artif Intern Organs J2019; 65(1): 11–20. DOI: 10.1097/MAT.0000000000000755.
9.
DonkerDWSallisalmiMBrooméM. Right-left ventricular interaction in left-sided heart failure with and without venoarterial extracorporeal membrane oxygenation support-A simulation study. Am Soc Artif Intern Organs J2021; 67(3): 297–305. DOI: 10.1097/MAT.0000000000001242.
10.
ColasantiSPiemonteVDevolderE, et al.Development of a computational simulator of the extracorporeal membrane oxygenation and its validation with in vitro measurements. Artif Organs2020; 45(4): 399–410. DOI: 10.1111/aor.13842.
11.
ProttiIvan den EndenAMeaniP, et al. Tailoring the best positive end-expiratory pressure through invasive right ventricular pressure-volume loops in a patient supported by veno-arterial extracorporeal membrane oxygenation. Am Soc Artif Intern Organs J. 2024. DOI:10.1097/MAT.0000000000002238.
12.
EzadSMRyanMDonkerDW, et al.Unloading the left ventricle in venoarterial ECMO: in whom, when, and how?Circulation2023; 147(16): 1237–1250. DOI: 10.1161/CIRCULATIONAHA.122.062371.
13.
BoxGEP. Robustness in the strategy of scientific model building. In: LaunerRLWilkinsonGN (eds). Robustness in Statistics. Cambridge, MA: Academic Press, 1979, pp. 201–236. DOI: 10.1016/B978-0-12-438150-6.50018-2.
14.
WarnaarRSPMulderMPFresielloL, et al.Computational physiological models for individualised mechanical ventilation: a systematic literature review focussing on quality, availability, and clinical readiness. Crit Care2023; 27(1): 268. DOI: 10.1186/s13054-023-04549-9.
15.
PladetLLuijkenKFresielloL, et al.Clinical decision support for ExtraCorporeal membrane oxygenation: will we fly by wire?Perfusion2023; 38(1_suppl): 68–81. DOI: 10.1177/02676591231163688.
