A change of oxygenator during cardiopulmonary bypass is a technically high-risk procedure with potential for a serious adverse event for the patient. This case report describes a case of increased pressure drop and pre-oxygenator blood pressure during cardiopulmonary bypass successfully treated with pre-oxygenator-administered epoprostenol.
SeraV.Primum non nocere: patient safety in cardiopulmonary bypass. In: GravleeGPDavisRFStammersAHUngerleiderRM (eds) Cardiopulmonary bypass: principles and practice. 3rd ed.Philadelphia: Lippincott Williams & Wilkins, 2008, pp. 589–607.
2.
SchaadtJ.Oxygenator thrombosis: an international phenomenon. Perfusion1999; 14: 425–435.
3.
FisherARBakerMBuffinMet al. Normal and abnormal trans-oxygenator pressure gradients during cardiopulmonary bypass. Perfusion2003; 18: 25–30.
4.
HesselEAII. Circuitry and cannulation techniques. In: GravleeGPDavisRFStammersAHUngerleiderRM (eds). Cardiopulmonary bypass: principles and practice. 3rd ed.Philadelphia: Lippincott Williams & Wilkins, 2008, pp. 63–113.
5.
MyersGJWeighellPRMcCloskeyBJHoltAMMcTeerSMaxwellSL.A multicenter investigation into the occurrence of high-pressure excursions. J Extra Corpor Technol2003; 35: 127–132.
6.
WendelHPPhilippAWeberNBirnbaumDEZiemerG.Oxygenator thrombosis: worst case after development of an abnormal pressure gradient-incidence and pathway. Perfusion2001; 16: 271–278.
7.
ThunbergCAGaitanBDGrewalARamakrishnaHStansburyLGGrigoreAM.Pulmonary hypertension in patients undergoing cardiac surgery: pathophysiology, perioperative management, and outcomes. J Cardiothorac Vasc Anesth2013; 27: 551–572.
8.
MoitraVKSladenRN.Cardiopulmonary bypass and the lung. In: GravleeGPDavisRFStammersAHUngerleiderRM (eds) 3rd ed.Cardiopulmonary bypass: principles and practice. Philadelphia: Lippincott Williams & Wilkins, 2008, p. 311–20.
9.
TamburrelliCCrescenteMIzziBet al. Epoprostenol inhibits human platelet-leukocyte mixed conjugate and platelet microparticle formation in whole blood. Thromb Res2011; 128: 446–451.
10.
CawelloWSchweerHMüllerRBonnRSeyberthH.Metabolism and pharmacokinetics of prostaglandin E 1 administered by intravenous infusion in human subjects. Eur J Clin Pharmacol1994; 46: 275–277.
11.
DeepAZohaMKukrejaPD.Prostacyclin as an anticoagulant for continuous renal replacement therapy in children. Blood Purification2017; 43: 279–289.