We present a case series of seven patients with suspected cold agglutinin antibodies, discovered after initiation of bypass. Laboratory analysis of blood samples intraoperatively determined the cause of the aggregation to be rouleaux formation in three of the patients and cold agglutinins in the other four.
FischerGDClaypooleVCollardCD. Increased pressures in the retrograde blood cardioplegia line: an unusual presentation of cold agglutinins during cardiopulmonary bypass. Anesth Analg1997; 84: 454–456.
2.
AtkinsonVPSoedingPHorneGTatoulisJ. Cold agglutinins in cardiac surgery: management of myocardial protection and cardiopulmonary bypass. Ann Thorac Surg2000; 85: 310–311.
3.
YalamuriSHeathMMcCartneySCushmanTMaxwellC. Cardiopulmonary bypass management complicated by a stenotic coronary sinus and cold agglutinins. J Cardiothorac Vasc Anesth2017; 31: 233-235.
4.
JainMDCabrerizo-SanchezRKarkoutiKYauTPendergrastJMCserti-GazdewichCM. Seek and you shall find–but then what do you do? Cold agglutinins in cardiopulmonary bypass and a single-center experience with cold agglutinin screening before cardiac surgery. Transfus Med Rev2013; 27: 65–73.
5.
BarshsteinGRonenBASaulY. Role of red blood cell flow behavior in hemodynamics and hemostasis. Expert Review of Cardiovascular Therapy2007; 5: 743–752.
6.
TalstadIScheiePDalenHRoliJ. Influence of plasma proteins on erythrocyte morphology and sedimentation. Scand J Haematol1983; 31: 478–484.
7.
AtaşHCemilBÇKurmuşGIGönülM. Assessment of systemic inflammation with neutrophil-lymphocyte ratio in lichen planus. Advances in Dermatology and Allergology/Postȩpy Dermatologii I Alergologii2016; 33: 188–192.
KwaanH. Role of plasma proteins in whole blood viscosity: a brief clinical review. Clin Hemorheol Micro2010; 44: 167–176.
11.
MorelliRMayJBachJF. Clinical Studies of Complement. New York: Ardent Media, 1974: p.157.
12.
HoffmanJWJr.GilbertTBHyderM. Cold agglutinins complicating repair of aortic dissection using cardiopulmonary bypass and hypothermic circulatory arrest: case report and review. Perfusion2002; 17: 391–394.
13.
RodakBFritsmaGKeohaneE. Hematology: clinical principles and applications. New York: Elsevier Health Sciences, 2013: p.172
14.
WilliamsLDomenRE. Vancomycin induced red cell aggregation. Transfusion1989; 29: 23–26.
15.
DakeSBJohnstonMFBrueggemanPBarnerHB. Detection of cold hemagglutination in a blood cardioplegia unit before systemic cooling of a patient with unsuspected cold agglutinin disease. Ann Thorac Surg1989; 47: 914–915.
AfrasiabiradASafaieNMontazergaemH. On-pump beating coronary artery bypass in high risk coronary patients. Iran J Med Sci2015; 40: 40–44.
18.
HiraokaAKuinoseMTotsugawaTChikazawaGYoshitakaH. Mitral valve reoperation under ventricular fibrillation through right mini-thoracotomy using three-dimensional videoscope. J Cardiothorac Surg2013; 8: 81.
19.
CandilioLMalikAAritiCet al. A retrospective analysis of myocardial preservation techniques during coronary artery bypass graft surgery: are we protecting the heart?J Cardiothorac Surg2014; 9: 184.
20.
ChenLLvLLongCLouS. Effects of circuit albumin coating on coagulation and inflammatory response for patients receiving aortic arch replacement: a randomized controlled trial. Perfusion2016; 31: 576–583.
