An in vitro evaluation of gaseous microemboli handling by contemporary venous reservoirs and oxygenator systems using EDAC

Abstract

Gaseous microemboli (GME) generated during cardiopulmonary bypass (CPB) can present a significant risk to patient outcomes, specifically if they are delivered to the cerebral vasculature. A number of GME sources have been identified, leading to improved clinical practice and equipment design to ameliorate the presence and intensity of GME during CPB. Recently, a number of new venous reservoir/oxygenator systems have entered the market, including the Sorin Inspire6 and Inspire8, the Terumo FX15 and FX25 and the Maquet Quadrox-i. The goal of the current study was to evaluate the GME-handling capacity of these contemporary venous reservoirs, oxygenators and complete systems, as well as our currently used Sorin Synthesis, using the EDAC system. The venous reservoir of the Quadrox-i was the most effective in removing all sizes of GME and total GME load, while the Synthesis was the least effective. The FX15 and FX25 were least effective removing small GME, while the FX15 and Quadrox-i were the least effective at removing medium GME. The Quadrox-i was least effective at removing large GME. In terms of complete venous reservoir/oxygenator systems, the Synthesis permitted the greatest amount of GME to pass, while the other systems appeared largely equivalent.