Modelling lung and tissue diffusion using a membrane oxygenator circuit

Abstract

A simple model lung has been designed using a membrane oxygenator circuit comprising two membrane oxygenators primed with one to two litres of equine blood, giving reproducible results over several hours. Normoxia and normocapnia were achieved consistently over the duration of the test with a blood flow of 2.5 l/min, oxygenator ventilation gas flow of 5 l/min air with 0.3 l/min O₂ and deoxygenator ventilation gas flow of 5 l/min 5% CO₂ in N₂ with 0.2 l/min CO₂. The measured PaO₂ was 81.3 (SD 3.35 mmHg), PvO₂ 38.3 (SD 1.38 mmHg), PvCO₂ 60.6 (SD 1.13 mmHg) and PaCO₂ 36.1 (SD 0.69 mmHg). MO₂ and MCO₂ were 116 ml/min and 169 ml/min, respectively. An increasing linear relationship was observed for FiO₂ and the corresponding PaO₂ and, similarly, with FiCO₂ and PvCO₂, providing reference ranges for this model. Perfusion (2007) 22, 231—238.

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