Postoperative complications associated with blood transfusions are frequently
reported to be a result of the transfused leukocytes. This paper examines the
effects of leukocyte depletion. Leukocyte depletion by filtration which can reduce
leukocyte presence by more than 99.9%. The implications of this are postulated in
terms of the results that may be obtained.
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References
1.
Jensen LS, Andersen AJ, Christiansen PMet al.Postoperative infection and natural killer cell function following blood
transfusion in patients undergoing elective colorectal surgery. Br J Surg1992; 79: 513-516.
2.
Houbiers JG, van de Watering LM, Hermans Jet al.Randomised controlled trial comparing transfusion of leukocyte depleted or
buffy-coat-depleted blood in surgery for colorectal cancer. Lancet1994; 344: 573-578.
3.
Jensen LS, Kissmeyer-Nielsen P, Wolff B, Qvist N.Randomised comparison of leucocyte-depleted versus buffy-coat-poor blood
transfusion and complications after colorectal surgery. Lancet1996; 348, 841-845.
4.
van de Watering LM, Hermans J, Houbiers JGet al.Beneficial effects of leukocyte depletion of transfused blood on
postoperative complications in patients undergoing cardiac surgery. A
randomised clinical trial. Circulation1998; 97: 562-568.
5.
The Serious Hazards of Transfusion Steering Group. Serious Hazards Of Transfusion annual report 1998-1999. Manchester Blood Centre: SHOT Steering Group, 2000.
