The Use of Transgenic Animals in the European Union

Anon. (1994). ECVAM News & Views. ATLA 22, 7–11.

Maclean N. , ed. (1995). Animals With Novel Genes, 282 pp. Cambridge, UK: Cambridge University Press.

Gordon J.W. (1996). Transgenic technology and its impact on laboratory animal science. Scandinavian Journal of Laboratory Animal Science 23, 235–249.

Beardmore J.A. (1997). Transgenics, autotransgenics and allotransgenics. Transgenics Research 6, 107–108.

Anon. (1997). Statistics of Scientific Procedures on Living Animals — Great Britain, 1996, Cm 3722, p. 30. London: HMSO.

Hubrecht R. (1995). Genetically modified animals, welfare and UK legislation. Animal Welfare 4, 163–170.

Moore C.J. , and Mepham T.B. (1995). Transgenesis and animal welfare. ATLA 23, 380–397.

van Zutphen L.F.M. , & van der Meer M. eds (1997). Welfare Aspects of Transgenic Animals, 119 pp. Berlin: Springer-Verlag.

Poole T. (1997). Transgenic animals: an alternative? Opponent's statement. In Developments in Animal and Veterinary Sciences, Vol. 27, Animal Alternatives, Welfare and Ethics (ed. van Zutphen L.F.M. , & Balls M. ), pp. 267–272. Amsterdam: Elsevier.

Anon. (1997). Guidelines on Transgenic Animals, 9 pp. Ottawa, Canada.: CCAC.

Tomizuka K. , Yoshida H. , Uejimi H. , Kugoh H. , Sato K. , Ohguma A. , Hayasaka M. , Hanaoka K. , Oshimura M. , and Ishida I. (1997). Functional expression and germline transmission of a human chromosome fragment in chimaeric mice. Nature Genetics 16, 133–143.

Anon. (1997). Europe ambivalent on biotechnology. Nature 387, 845–847.

Sandoe P. , Forsman B. , and Hansen A.K. (1996). Transgenic animals: the need for ethical dialogue. Scandinavian Journal of Laboratory Animal Science 23, 279–285.

Anon. (1996). Group of Advisers to the European Commission on the Ethical Implications of Biotechnology, 24 pp. Luxembourg: Office for the Official Publications of the European Communities.

Balls M. , Goldberg A.M. , Fentem J.H. , Broad-head C.L. , Burch R.L. , Festing M.F.W. , Frazier J.M. , Hendriksen C.F.M. , Jennings M. , van der Kamp M.D.O. , Morton D.B. , Rowan A.N. , Russell C. , Russell W.M.S. , Spielmann H. , Stephens M.L. , Stokes W.S. , Straughan D.W. , Yager J.D. , Zurlo J. , & van Zutphen B.F.M. (1995). The Three Rs: the way forward. The report and recommendations of ECVAM workshop 11. ATLA 23, 838–866.

Bedell M.A. , Largaespada D.A. , Jenkins N.A. , and Copeland N.G. (1997). Mouse models of human disease. II. Recent progress and future directions. Genes and Development 11, 11–43.

Woychick R.P. , Wassom J.S. , and Kingsbury D. (1993). TBASE: a computerized database for transgenic animals and targeted mutations. Nature 363, 375–376.

Dorin J.R. , Dickinson P. , Alton E.W.F.W. , Smith S.N. , Geddes D.M. , Stevenson B.J. , Kimber W.L. , Fleming S. , Clarke A.R. , Hooper M.L. , Anderson L. , Beddington R.S.P. , and Porteous D.J. (1992). Cystic fibrosis in the mouse by targeted insertional mutagenesis. Nature 359, 211–215.

Forster R. (1995). Measuring genetic events in transgenic animals. In Environmental Mutagenesis (ed. Phillips D.H. , Venitt S. ), pp. 291–314. Oxford, UK: Bios Scientific Publishers.

Gorelick N.J. (1995). Overview of mutation assays in transgenic mice for routine testing. Environmental and Molecular Mutagenesis 25, 218–230.

Suzuki T. , Hayashi M. , Sofuni T. , and Myhr B.C. (1993). The concomitant detection of gene mutation and micronucleus induction by mitomycin C in vivo using lac Z transgenic mice. Mutation Research 285, 219–224.

Gossen J.A. , Martus H-J. , Wei J.Y. , and Vijg J. (1995). Spontaneous and X-ray induced deletion mutations in a lac Z plasmid-based transgenic mouse model. Mutation Research 331, 89–97.

Haseman J.K. , and Lockhardt A. (1994). The relationship between the use of the maximum tolerated dose and study sensitivity for detecting rodent carcinogenicity. Fundamental and Applied Toxicology 22, 382–391.

Kroese E.D. , van Steeg H. , van Oostrom C.T. , Dortant P.M. , Wester P. , van Kranen H.J. , de Vries A. , & van Kreijl C.F. (1997). Use of E-pim transgenic mice for short-term in vivo carcinogenicity testing: lymphoma induction by benzo[a]pyrene but not TPA. Carcinogenesis 19, 975–980.

Tennant R.W. , French J.E. , and Spalding J.W. (1995). Identifying chemical carcinogens and assessing potential risks in short-term bioassays using transgenic mouse models. Environmental Health Perspectives 103, 942–950.

Yamamoto S. (1996). Rapid induction of more malignant tumours by various genotoxic carcinogens in transgenic mice harbouring human proto-type c-H-ras gene than in control non-transgenic mice. Carcinogenesis 17, 2455–2461.

De Vries A. , van Oostrom C.T.M. , Dortant P.M. , Beems R.B. , van Kreijl C.F. , Capel P.J.A. , & van Steeg H. (1997). Spontaneous liver tumours and benzo[a]pyrene-induced lymphomas in XPA-deficient mice. Molecular Carcinogenesis 19, 46–53.

Anon. (1997). Report on the Current Status of Harmonisation, Fourth International Conference on Harmonisation, 18 pp. Belgium: ICH.

Ronchi E. (1996). Advances in Transplantation Biotechnology: Animal to Human Organ Transplants, Xenotransplantation, OECD/GD 96/167, 28 pp. Paris: OECD.

Houdebine L.M. (1994). Production of pharmaceutical proteins from transgenic animals. Journal of Biotechnology 34, 269–287.

Wall R.J. (1996). Transgenic livestock: progress and prospects for the future. Theriogenology 45, 57–68.

Wall R.J. (1996). Modification of milk composition in transgenic animals. In Biotechnology's Role in the Genetic Improvement of Farm Animals (ed. Miller R.H. , Pursell V.G. , Norman H.D. ), pp. 165–188. Savoy, IL, USA: The American Society of Animal Science.

Sharma A. , Martin M.J. , Okabe J.F. , Truglio R.A. , Dhanjal N.K. , Logan J.S. , and Khumar R. (1994). An isologous porcine promoter permits high level expression of human hemoglobin in transgenic swine. Bio/Technology 12, 55–59.

Rosengard A.M. , Cary N.R.B. , Langford G.A. , Tucker A.W. , Wallwork J. , and White D.J.G. (1995). Tissue expression of human complement inhibitor decay-accelerating factor in transgenic pigs. Transplantation 59, 1325–1333.

Pursel V.G. , and Rexroad C.E. (1993). Status of research with transgenic farm animals. Journal of Animal Science 71, Suppl. 3, 10–19.

Rexroad C.E. (1994). Transgenic farm animals. ILAR News 36, 5–9.

Powell B.C. , Walker S.K. , Bawden C.S. , Sivaprasad A.V. , and Rogers G.E. (1994). Transgenic sheep and wool growth: possibilities and current status. Reproduction, Fertility and Development 6, 615–623.

Damak S. , Su H.Y. , Jay N.P. , and Bullock D.W. (1996). Improved wool production in transgenic sheep expressing insulin-like growth factor 1. Bio/Technology 14, 185–188.

Müller M. , and Brem G. (1996). Intracellular, genetic or congenital immunisation: transgenic approaches to increase disease resistance of farm animals. Journal of Biotechnology 44, 233–242.

van Reenen C.G. , and Blockhuis H.J. (1993). Investigating welfare of dairy calves involved in genetic modification: problems and perspectives. Livestock Production Science 36, 81–90.

van Reenen C.G. , and Blockhuis H.J. (1997). Evaluation of welfare of transgenic farm animals: lessons from a case study in cattle. Journal of the Royal Swedish Academy of Agriculture and Forestry 136, 99–105.

Walker S.K. , Hartwich K.M. , and Seamark R.F. (1996). The production of unusually large offspring following embryo manipulation: concepts and challenges. Theriogenology 45, 111–120.

Kruip T.A.M. , & den Daas J.H.G. (1997). In vitro produced and cloned embryos: effects on pregnancy, parturition and offspring. Theriogenology 47, 43–52.

Canseco R.S. , Spark A.E.T. , Page R.L. , Russell C.G. , Johnson J.L. , Velander W.H. , Pearson R.E. , Drohan W.N. , and Gwazdauskas F.C. (1994). Gene transfer efficiency during gestation and influence of co-transfer of non-manipulated embryos in production of transgenic mice. Transgenic Research 3, 20–25.

Page R.L. , Canseco R.S. , Russell C.G. , Johnson J.L. , Velander W.H. , and Gwazdauskas F.C. (1995). Transgene detection during early murine embryonic development after pronuclear microinjection. Transgenic Research 4, 12–17.

Gordon J.W. (1989). Transgenic animals. International Reviews of Cytology 115, 171–229.

Pursel V.G. , Pinkert C.A. , Miller K.F. , Bolt D.J. , Campbell R.G. , Palmiter R.D. , Brinster R.D. , and Hammer R.E. (1989). Genetic engineering of livestock. Science 254, 1281–1288.

Strohman R. (1994). Epigenesis: the missing beat of biotechnology. Bio/Technology 12, 156–164.

Sippel A.E. , Saueressig H. , Hubler M.C. , Faust N. , and Bonifer C. (1997). Insulation of transgenes from chromosomal position effects. In Transgenic Animals: Generation and Use (ed. Houdebine L.M. ), pp. 257–266. Amsterdam: Harwood Academic Publishers.

Shockett P.E. , and Schatz D.G. (1996). Diverse strategies for tetracycline-regulated inducible gene expression. Proceedings of the National Academy of Sciences, USA 93, 5173–5176.

Viville S. (1997). Mouse genetic manipulation via homologous recombination. In Transgenic Animals: Generation and Use (ed. Houdebine L.M. ), pp. 307–322. Amsterdam: Harwood Academic Publishers.

Anon. (1996). Animal-to-Human Transplants: The Ethics of Xenotransplantation, 146 pp. London: Nuffield Council.

Wolf E. (1997). Transgenic animals: an alternative? Proponent's statement. In Developments in Animal and Veterinary Sciences, Vol. 27, Animal Alternatives, Welfare and Ethics (ed. van Zutphen L.F.M. , & Balls M. ), pp. 261–265. Amsterdam: Elsevier.

Fakamizu A. , and Murakami K. (1997). Activated and inactivated renin-angiotensin system in transgenic animals: from gene to blood pressure. Laboratory Animal Science 47, 127–130.

Leder A. , Kuo A. , Cardiff R.D. , Sinn E. , and Leder P. (1990). v-H-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid. Proceedings of the National Academy of Sciences, USA 87, 9178–9182.

Massoud M. , Attal J. , Thépot D. , Pointu H. , Stinnakre M.G. , Théron M.C. , Lopez C. , and Houdebine L.M. (1996). The deleterious effects of human erythropoietin gene driven by the rabbit whey acidic protein gene promoter in transgenic rabbits. Reproduction, Nutrition and Development 36, 555–563.

Wall R.J. , Rexroad C.E. , Powell A. , Shamay A. , McKnight R. , and Hennighausen L. (1996). Synthesis and secretion of the mouse whey acidic protein in transgenic sheep. Transgenic Research 5, 67–72.

Devinoy E. , Stinnakre M.G. , Lavialle F. , Thépot D. , & Ollivier-Bousquet M. (1995). Intracellular routing and release of caseins and growth hormone produced into milk from transgenic mice. Experimental Cell Research 221, 272–280.

Shamay A. , Pursel V.G. , Wilkinson F. , Wall R.J. , and Hennighausen L. (1992). Expression of the whey acidic protein in transgenic pigs impairs mammary development. Transgenic Research 1, 124–132.

Crittenden L.B. , and Salter D.W. (1992). A transgene, alv 6, that expresses the envelope of subgroup a avian leukosis virus reduces the rate of congenital transmission of a field strain of avian leukosis virus. Poultry Science 71, 799–806.

Gavora J.S. , Benkel B. , Spencer J.L. , Gagnon C. , and Crittenden L.B. (1995). Influence of the alv 6 recombinant avian leukosis virus transgene on production traits and infection with avian tumor viruses in chickens. Poultry Science 74, 852–863.

Broom D.M. , and Johnson KG. (1993). Stress and Animal Welfare, 211 pp. London: Chapman and Hall.

Hughes B.O. , Hughes G.S. , Waddington D. , and Appleby M.C. (1996). Behavioural comparison of transgenic and control sheep: movement order, behaviours on pasture and in covered pens. Animal Science 63, 91–101.

Anon. (1993). Biotechnology and genetic engineering: what Europeans think about it in 1993. Eurobarometer 39, 1.

van der Meer M. , & van Zutphen L.F.M. (1997). Use of transgenic animals and welfare implications. In Welfare Aspects of Transgenic Animals (ed. van Zutphen v , & van der Meer M. ), pp. 78–89. Berlin: Springer Verlag.

Rollin B. (1986). On telos and genetic manipulation. Between the Species 2, 88–89.

Verhoog H. (1992). The concept of intrinsic value and transgenic animals. Journal of Agricultural and Environmental Ethics 5, 147–160.

Verhoog H. (1996). Genetic modification of animals: should science and ethics be integrated? The Monist 79, 247–263.

Vorstenbosch J. (1993). The concept of integrity. Livestock Production Science 36, 109–112.

Donnelley S. , McCarthy C.R. , and Singleton R. (1994). The brave new world of animal biotechnology. Hastings Centre Report 24, Suppl., 31 pp.

O'Riordan T. , and Jordan A. (1995). The precautionary principle in contemporary environmental politics. Environmental Values 4, 191–212.

Mepham T.B. , Moore C.J. , and Crilly R.E. (1996). An ethical analysis of the use of xenografts in human transplant surgery. Bulletin of Medical Ethics 116, 13–18.

Kockelkoren P.J.H. (1993). Ethical Aspects of Plant Biotechnology, 45 pp. The Netherlands: Ministry of Agriculture, Nature Management and Fisheries, Department of Science and Technology.

Smith J.A. , and Boyd K.M. (1991). Lives in the Balance: The Ethics of Using Animals in Biomedical Research, 352 pp. Oxford: Oxford University Press.

Porter D.G. (1992). Ethical scores for animal experiments. Nature 356, 101–102.

de Cock Buning T. , and Theune E.P. (1994). A comparison of three models for ethical evaluation of proposed animal experiments. Animal Welfare 3, 107–128.

Whitehead R.H. , and Joseph J.L. (1994). Derivation of conditionally immortalized cell lines containing Min mutation from the normal colonic mucosa and other tissue of an ‘Immortomouse'/Min hybrid. Epithelial Cell Biology 3, 119–125.

Dickinson P. , Dorin J.R. , and Porteous D.J. (1995). Modelling cystic fibrosis in the mouse. Moledular Medicine Today 1, 140–148.

Wolf E. , Kahnt E. , Ehrlein J. , Hermanns W. , Brem G. , and Wanke R. (1993). Effects of long-term elevated serum levels of growth hormone on life expectancy of mice: lessons from transgenic animal models. Mechanisms of Ageing and Development 68, 71–87.

Mepham T.B. (1996). Ethical analysis of food biotechnologies: an evaluative framework. In Food Ethics (ed. Mepham T.B. ), pp. 101–119. London: Routledge.

Beauchamp T.L. , and Childress J.F. (1994). Principles of Biomedical Ethics, 560 pp. New York: Oxford University Press.