Monoclonal Antibody Production

Anon. (1994). ECVAM News & Views. ATLA 22, 7–11.

Köhler G. , and Milstein C. (1975). Continuous cultures of fused cells secreting antibody of predefined specificity. Nature, London 256, 495–497.

Schade R. , Staak C. , Hendriksen C. , Erhard M. , Hugl H. , Koch G. , Larsson A. , Pollmann W. , van Regenmortel M. , Rijke E. , Spielmann H. , Steinbusch H. , and Straughan D. (1996). The production of avian (egg yolk) antibodies: IgY. The report and recommendations of ECVAM workshop 21. ATLA 24, 925–934.

Anon. (1989). Code of Practice for the Production of Monoclonal Antibodies, 6 pp. Rijswyk, The Netherlands: Veterinary Public Health Inspectorate, Department of Animal Experimentation.

Kuhlmann I. , Kurth W. , and Ruhdel I. (1989). Monoclonal antibodies: in vivo and in vitro production on a laboratory scale, with consideration of the legal aspects of animal protection. ATLA 17, 73–82.

Porter W.P. , Quander R.V. , and Rener J.C. (1990). Laboured breathing in ascites-producing mice. Lab Animals 18, 21–22.

van der Kamp M. , & de Leeuw W.A. (1996). Short review of in vitro production methods for monoclonal antibodies. NCA Newsletter 3, 10–12.

Hewish D. (1996). Ascites and alternatives. ANZCCART News 9, 8–10.

Kovar J. , and Franek F. (1984). Serum-free medium for hybridoma and parental myeloma cultivation: a novel composition of growth-supporting substances. Immunology Letters 7, 339–345.

Chang T.H. , Steplewski Z. , and Koprowski H. (1980). Production of monoclonal antibodies in serum-free medium. Journal of Immunological Methods 39, 369–375.

Fike R.M. , Jayme D.W. , and Weiss S.A. (1991). Monoclonal antibody enhancement in protein-free and serum-supplemented hybridoma culture. American Biotechnology Laboratory 9, 40–42.

Mizrahi A. (1977). Primatone® RL in mammalian cell culture media. Biotechnology and Bio-engineering 13, 1557–1561.

Velez D. , Reuveny S. , Miller L. , and Macmillan J.D. (1986). Kinetics of monoclonal antibody production in low serum growth medium. Journal of Immunological Methods 86, 45–52.

Schacter E. (1989). Serum-free medium for bulk culture of hybridoma cells and the preparation of monoclonal antibodies. Trends in Biotechnology 7, 248–253.

Hewlett G. (1991). Strategies for optimising serum-free media. Cytotechnology 5, 3–14.

Stoll T. , Mohlethaler K. , von Stockar U. , and Marison I. (1996). Systematic improvement of a chemically-defined protein-free medium for hybridoma growth and monoclonal antibody production. Journal of Biotechnology 45, 111–123.

Stoll T. , Chappaz A. , von Stockar U. , and Marison I. (1997). Effects of culture conditions on the production and quality of monoclonal IgA. Enzyme and Microbial Technology, in press.

Chua F. , Oh S. , Yap M. , and Tea W. (1994). Enhanced IgG production in cRDF media with and without serum. Journal of Immunological Methods 167, 109–119.

Parekh R.B. , Dwek R.A. , Sutton B.J. , Fernandes D.L. , Leung A. , Stanworth D. , and Rademacher T.W. (1985). Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG. Nature, London 316, 452–456.

Leatherbarrow R.J. , Rademacher T.W. , and Dwek R.A. (1985). Effector functions of a monoclonal aglycosylated mouse IgG2a: binding and activation of complement component C1 and interaction with human monocyte Fc receptor. Molecular Immunology 22, 407–415.

Leibiger H. , Hansen A. , Schoenherr G. , Seifert M. , Wustner D. , Stigler R. , and Marx U. (1995). Glycosylation analysis of a polyreactive human monoclonal IgG antibody derived from a human-mouse heterohybridoma. Molecular Immunology 32, 595–602.

Fischer R.W. , and Ferber P.C. (1992). Monoklonale Antikoerper: In vitro-Produktionsmethoden im Vergleich. Alternativen zu Tierexperimenten 16, 15–24.

Stoll T. , Perregaux C. , von Stockar U. , and Marison I.W. (1995). Production of immunoglobulin A in different reactor configurations. Cytotechnology 17, 53–63.

Jackson L.R. , Trudel L.J. , Fox J.G. , and Lipman N.S. (1996). Evaluation of hollow fibre bioreactors as an alternative to murine ascites production for small scale monoclonal antibody production. Journal of Immunological Methods 189, 217–231.

Hendriksen C. , Rozing J. , van der Kamp M. , & de Leeuw W. (1996). The production of monoclonal antibodies: are animals still needed? ATLA 24, 109–110.

Winter G. , Griffiths A.D. , Hawkins R.E. , and Hoogenboom H.R. (1994). Making antibodies by phage display technology. Annual Review of Immunology 12, 433–455.

Burton D. , and Barbas C.F. 3rd (1994). Human antibodies from combinatorial libraries. Advances in Immunology 57, 191–280.

de Kruif J. , van der Vuurst de Vries A-R. , Cilenti L. , Boel E. , van Ewijk W. , and Logtenberg T. (1996). New perspectives on recombinant human antibodies. Immunology Today 17, 453–455.

Devlin J.J. , Panganiban L.C. , and Devlin P.E. (1990). Random peptide libraries: a source of specific protein binding molecules. Science 249, 404–406.

Anon. (1986). Council Directive 86/609/EEC of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes. Official Journal of the European Communities L358, 1–29.

Anon. (1986). European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes, 51 pp. Strasbourg: Council of Europe.

Anon. (1986). Animals (Scientific Procedures) Act 1986, 24 pp. London: HMSO.

Anon. (1992). Report of the Animal Procedures Committee for 1991, Appendix II, Cmnd 2048, 37 pp. London: HMSO.

Anon. (1995). Tierschutzbericht 1995, Drucksache 13/350, pp. 59–60. Bonn: Bundesministerium für Ernährung, Landwirtschaft und Forsten.

Anon. (1994). The [Swedish] Animal Protection Act (1988:535, as amended by 1990:628, 1991:1688 and 1992:1095). In Provisions and General Recommendations Relating to the Use of Animals for Scientific Purposes (ed. Lundgren O. ), pp. 1–5. Stockholm: Karl Olov Öster.

Anon. (1994). General recommendations of the National Board for Laboratory Animals on the treatment of certain matters relating to ethical reviews of the use of animals for scientific purposes (LSFS/Statute book of the National Board of Agriculture/1990:21, Subject no L29). In Provisions and General Recommendations Relating to the Use of Animals for Scientific Purposes (ed Lundgren O. ), pp. 43–45. Stockholm: Karl Olov Öster.