The Use of Tissue Slices for Pharmacotoxicology Studies

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Vickers A.E.M. , Fisher R.L. , Brendel K. , Guertler J. , Dannecker R. , Keller B. , and Fischer V. (1995). Sites of biotransformation for the cyclosporin derivative SDZ IMM 125 using human liver and kidney slices and intestine. Comparison with rat liver slices and cyclosporin A metabolism. Drug Metabolism and Disposition 23, 327–333.

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Vickers A.E.M. , Fischer V. , Connors M.S. , Biggi W.A. , Heitz F. , Baldeck J-P. , & Brendel K. (1996). Biotransformation of the antiemetic 5-HT3 antagonist tropisetron in liver and kidney slices of human, rat and dog with a comparison to in vivo. European Journal of Drug Metabolism and Pharmacokinetics 21, 43–50.

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Vickers A.E.M. , Connors S. , Zollinger M. , Biggi W.A. , Larrauri A. , Vogelaar J.P.W. , and Brendel K. (1993). The biotransformation of the ergot derivative CQA 206–291 in human, dog, and rat liver slice cultures and prediction of in vivo plasma clearance. Drug Metabolism and Disposition 21, 454–459.

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Smith P.F. , Fisher R. , Shubat P.J. , Gandolfi A.J. , Krumdieck C.L. , Koep L.J. , and Brendel K. (1987). In vitro cytotoxicity of allyl alcohol and bromobenzene in a novel organ culture system. Toxicology and Applied Pharmacology 87, 509–522.

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Ghantous H.N. , Fernando J. , Gandolfi A.J. , and Brendel K. (1992). Sevoflurane is biotrans-formed by guinea-pig liver slices but causes minimal cytotoxicity. Anesthesiology and Analgesia 75, 436–440.

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Ghantous H.N. , Fernando J. , Gandolfi A.J. , and Brendel K. (1990). Toxicity of halothane in guinea-pig liver slices. Toxicology 62, 59–69.

Payne A.K. , Morgan S.E. , Gandolfi A.J. , and Brendel K. (1995). Biotransformation of sevoflurane by rat neonate liver slices. Drug Metabolism and Disposition 23, 497–500.

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Payne A.K. , Morgan S.E. , Gandolfi A.J. , and Brendel K. (1995). Biotransformation of sevoflurane by rat neonate liver slices. Drug Metabolism and Disposition 23, 497–500.

Azri-Meehan S. , Mata H.P. , Gandolfi A.J. , and Brendel K. (1992). The hepatotoxicity of chloroform in precision-cut rat liver slices. Toxicology 73, 239–250.

Azri-Meehan S. , Mata H.P. , Gandolfi A.J. , and Brendel K. (1994). The interactive toxicity of CHCl₃ and BrCCl₃ in precision-cut rat liver slices. Toxicology and Applied Pharmacology 22, 172–177.

Fisher R. , Brendel K. , and Hanzlik R.P. (1993). Correlation of metabolism, covalent binding and toxicity for a series of bromobenzene derivatives using rat liver slices in vitro Chemico-Biological Interactions 88, 191–208.

Fisher R. , Hanzlik R.P. , Gandolfi A.J. , and Brendel K. (1991). Toxicity of ortho-substituted bromobenzene in rat liver slices: a comparison to isolated hepatocytes. In Vitro Toxicology 4, 173–186.

Azri S. , Mata H.P. , Gandolfi A.J. , and Brendel K. (1991). CCl₄-induced cytochrome P450 loss and lipid peroxidation in rat liver slices. Advances in Experimental Medicine and Biology 283, 669–674.

Azri S. , Mata H.P. , Reid L.L. , Gandolfi A.J. , and Brendel K. (1992). Further examination of the selective toxicity of CCl₄ in rat liver slices. Toxicology and Applied Pharmacology 112, 81–86.

Wolfgang G.H. , Donarski W.J. , and Petry T.W. (1990). Effects of novel antioxidants on carbon tetrachloride-induced lipid peroxidation and toxicity in precision-cut rat liver slices. Toxicology and Applied Pharmacology 106, 63–70.

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Thompson DC. , Perera K. , Fisher R. , and Brendel K. (1994). Cresol isomers: comparison of toxic potency in rat liver slices. Toxicology and Applied Pharmacology 125, 51–58.

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Fisher R.L. , Gandolfi A.J. , Sipes I.G. , and Brendel K. (1993). Culture medium composition affects the relative toxicities of chlorobenzenes in rat liver slices and the isolated perfused liver. Drug and Chemical Toxicology 16, 321–339.

Fisher R.L. , Hasal S.J. , Sipes I.G. , Gandolfi A.J. , and Brendel K. (1995). Comparative metabolism and toxicity of dichlorobenzenes in Sprague-Dawley, Fischer-344 and human liver slices. Human and Experimental Toxicology 14, 414–421.

Fisher R. , McCarthy S. , Sipes I.G. , Hanzlik R.P. , and Brendel K. (1991). Metabolism of dichlorobenzenes in organ cultured liver slices. Advances in Experimental Medicine and Biology 283, 717–723.

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Wolfgang G.H. , Gandolfi A.J. , Stevens J.L. , and Brendel K. (1989). N-Acetyl-S-(l,2-dichlorovinyl)-L-cysteine produces a similar toxicity to S-(l,2-dichloro-vinyl)-L-cysteine in rabbit renal cortical slices: differential transport and metabolism. Toxicology and Applied Pharmacology 101, 205–219.

Wolfgang G.H. , Gandolfi A.J. , and Brendel K. (1989). Regioselective toxicity of dichlorovinyl cysteine in rabbit renal cortical slices. In Nephrotoxicity: Extrapolation from In Vitro to In Vivo, and Animals to Man (ed. Bach P.H. , Lock E.A. ), pp. 523–591. London: Plenum Press.

Wolfgang G.H.I. , Gandolfi A.J. , Stevens J.L. , and Brendel K. (1989). In vitro and in vivo nephrotoxicity of the L and D isomers of S-(1,2-dichlorovinyl)-cysteine. Toxicology 58, 33–42.

Fisher R. , Nau H. , Gandolfi A.J. , and Brendel K. (1991). Toxicity of valproic acid in Sprague-Dawley rat and domestic pig liver slices. Toxicology in Vitro 5, 201–205.

Fisher R.L. , Sanuik J.T. , Nau H. , Gandolfi A.J. , and Brendel K. (1991). Toxicity of valproic acid in adult and neonatal rats and human liver slices. Toxicology in Vitro 5, 371–379.

Parrish A.R. , Dorr R.T. , Gandolfi A.J. , and Brendel K. (1994). Adult rat myocardial slices: a tool for the study of comparative cardiotoxicity. Toxicology in Vitro 8, 1233–1237.

Lake B.G. , Beamand J.A. , Wield P.T. , and Price R.J. (1996). Use of precision-cut liver slices to evaluate species differences in 2-acetylaminofluorene-induced unscheduled DNA synthesis. Toxicology and Applied Pharmacology 138, 231–241.

Beamand J.A. , Price R.J. , Blowers S.D. , Wield P.T. , Cunninghame M.E. , and Lake B.G. (1994). Use of precision-cut liver slices for studies of unscheduled DNA synthesis. Food and Chemical Toxicology 32, 819–829.

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Fisher R.L. , Smith M.S. , Hasal S.J. , Hasal K.S. , Gandolfi A.J. , and Brendel K. (1994). The use of human lung slices in toxicology. Human and Experimental Toxicology 13, 466–471.

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