Intestinal Motility: A Computer Simulation of the Effects of Drugs on Colonic Peristalsis,for Teaching Undergraduate Pharmacology Students

Abstract

An interactive computer-assisted learning (CAD program, which simulates experiments performed on segments of rat colon (in vitro) to study the pharmacology of intestinal motility, is described. The program covers: a) the actions of drugs that affect cholinergic excitatory neurotransmission in the colon; b) the effects of sympathomimetic amines; and c) an investigation of the mechanism of action of the laxative, phenolphthalein.

The program can be run on any IBM-compatible PC, and makes use of text and high-resolution graphics to provide a background to the experiments and to describe the methodology. The screen display emulates a chart recorder, and simulated results, derived from actual data, are presented, in response to student selection of pre-determined experimental protocols from a menu. The program is aimed at undergraduate students, and is intended to support or replace a conventional laboratory practical class, while achieving the majority of the same teaching and learning objectives.

Keywords

CAL pharmacology teaching intestinal motility

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