Abstract
Neoplastic cell transformation by the carcinogenic epoxides, propylene oxide (PO) and epichlorohydrin (ECH), was investigated in two mammalian assays involving murine C3H/10T1/2 cells and Syrian hamster embryo (SHE) cells. In C3H/10T1/2 cells, PO increased the frequency of morphological transformations 9–18 times compared to the background frequency, at concentrations of 2.5–10mM (1-hour treatment). In SHE cells, a similar increase (5–15 times) was reached at concentrations of 5-20mM (8-day treatment). In both assays, ECH increased the frequency of morphological transformations only at the highest exposure levels (2mM for C3H/10T1/2 cells and 0.5mM for SHE cells).
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