The MEIC project is designed to evaluate the relevance of cytotoxicity data to the prediction of human toxicity. The large number of cytotoxicity tests and endpoints available makes it necessary to apply multivariate data-analytical methods in the evaluation procedure. PLS analysis of the cytotoxicity data collected so far for the first ten MEIC compounds indicate that the data are relevant for human toxicity. However, it was also apparent that the 14 cytotoxicity tests only showed slight differences, indicating that there is a need for other cytotoxicity tests (or endpoints) containing complementary information.
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