The cytotoxicities of HgCl2 (MC), CH3Hg Cl (MMC) and (C2H5)3SnCl (TET) were investigated in a mouse neuroblastoma cell line (C1300, clone NB41A3). General cytotoxicity was determined as TD25 and TD50 values in a cell detachment test and a monolayer growth test, respectively. Membrane toxicity was studied as increase in the efflux of tritiated 2-deoxy-D-glucose-6-phosphate from exposed cells, and metabolic effects as inhibition of oxygen consumption. It was found that the general endpoints (detachment and growth) correlated better to both animal and human in vitro toxicity than the more specific endpoints.
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