Abstract
Beating heart cells isolated from neonatal rats were used in an in vitro assay for testing the influence of chemical compounds on beating frequency. Half of the studied compounds had a no-effect level (NEL) in vivo based on changes in body weight or organ weight. Correlations were obtained between in vivo parameters such as LD50 values in acute toxicity studies and NELs in chronic toxicity studies, and in vitro parameters such as reduction in beating frequency and arrest of contraction. The in vitro parameters correlated well with in vivo LD50 values, but poorly with NELs in vivo.
Keywords
Get full access to this article
View all access options for this article.
