Less than a quarter of all experimental animals in Europe are used in toxicological experiments, and most of these are performed by the pharmaceutical industry. Acute toxicity testing, mainly LD50 tests, accounts for a large proportion of toxicological studies.
There are no defined animal numbers for special safety requirements in the Federal Republic of Germany (FRG). However, where the registration of chemical products in the FRG is concerned, numbers of animals used are documented.
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References
1.
BassR., GelbkeH.-P, GloxhuberC., GreimH., GünzelP., HenschlerD., HildebrandtA., KayserD., KönigJ., LorkeD., NeubertD., SchulzE., SchuppanD., and ZbindenG. (1984). New York: In Acute Toxicity Testing: Alternative Approaches (ed. GoldbergA.M.), pp. 173–179. New York: Mary Ann Liebert Inc.
2.
ScaifeM.C. (1985). The rabbit eye irritancy test—are there in vitro alternatives?Alternatives To Laboratory Animals12, 157–162.
3.
ZellR.A. (1985). Tierversuche. Sterben fur die Forschung.Bild der Wissenschaft22(1), 16–24.
4.
Anonymous (1985). Ein ungeheuerer Verschleiss an Tieren.Der Spiegel14, 36–53.
5.
RiesenhuberH. (1985). Versuchstierbedarf der aus Bundesmitteln finanzierten Forschung und Entwicklung (press release 49/85). Bonn: Bundesminster fuer Forschung und Technologie.
6.
Home Office (1985). Statistics of Experiments on Living Animals in Great Britain 1984 (Cmnd 9574). London: Home Office.
7.
SternH. (1979). Tierversuche in der Pharmaforschung, pp. 222–224. Munich: Kindler.
8.
FiebelkornJ., and LagoniN. (ed.) (1984). Tierschutzrelevanz von Datensammlungen uber Tierversuche und Alternativemethoden.BGA-Schriften 1/84.Munich: MMV Medizin Verlag.
9.
BPI (Association of the German Pharmaceutical Industry). (1981). Tiere in der Arzneimittelforschung, pp. 10–11. Frankfurt/Main: Bundesverban der Pharmazeutischen Industrie.
10.
WeidmannH. (1985). Stellung und Aufgabe des Tierversuchs in der angewandten Forschung.Swiss Pharma7, 6–11.
11.
HDI (Health Designs Inc.). (1984). Estimates of laboratory animal use in the US.HDI Toxicology Newsletter3, 3–4.
12.
OTA (Office of Technology Assessment). (1985). Alternatives to animal use in research, testing and education.The Johns Hopkins Center for Alternatives to Animal Testing Newsletter3, 3.
13.
HoldenC. (1985). HHS revises rules on animal research.Science228, 830.
14.
RozemondH. (1985). Animal Experimentation in the Netherlands, Statistics for 1984. Veterinary Public Health Inspectorate, Animal Experimentation Department, P.O. Box 439, 2260 Leidschendam, Netherlands.
National Academy of Sciences (1981). National Survey of Laboratory Animal Facilities and Resources, National Institutes of Health Publication 80/2091, Bethesda, MD., USA.
17.
HickeyT.E. (1984). Acute toxicity testing practice. In Acute Toxicity Testing: Alternative Approaches (ed. GoldbergA.M.), pp. 23–45. New York: Mary Ann Leibert Inc.
18.
OECD (Organisation for Economic Cooperation and Development). (1981). Guidelines for Testing of Chemicals, pp. 401–402. Paris: OECD.
19.
ZbindenG., & Flury-RoversiM. (1981). Significance of the LD50 test for the toxicological evaluation of chemical substances.Archives of Toxicology47, 77–99.
20.
Home Office (1984). Statistics Presented to Parliament by the Home Secretary (Cmnd 9311). London: Home Office.
21.
BassR. (1985). Problematik des LD50 Tests bei Tierversuchen.Bundesgesundheitsblatt28, 257–261.
22.
RTECS (1984). Registry of Toxic Effects of Chemical Substances, Cincinnati, Ohio, USA: National Institute for Occupational Safety and Health (NIOSH).
23.
BassR. (1984). Critical remarks on animal experimentation used in current procedures for risk evaluation of drugs and chemicals. In Registration and Decision-Making Processes for Drugs, Pesticides and Chemicals (ed. HerbstM., NeubertD.), pp. 4–19. Basel: Research and Consulting Company Ltd.
24.
ZbindenG. (1983). Konnen Tierversuche in der Toxikologie eingeschrankt werden? In Bedeutung und Notwendigkeit des Tierversuchs in der Experimentellen Biologic pp. 40–52. Basel: Union Schweizerischer Gesellschaften fuer Experimentelle Biologic
25.
Deutscher Bundestag (1983). Antwort des Parlamentarischen Staatssekretars Gallus auf die Anfrage der Abgeordneton Schmidt.Bundesdrucksache10/819, 20–21.
26.
BGA (Bundesgesundheitsamt) (1985). Tatigkeitsbericht 1984 des Bundesgesundheitsamtes, pp. 24. Munich: MMV Verlag.
27.
GünterK. (1984). Es geht auch mit weniger Tieren.Natur8, 42–43.
28.
Hessischer Landtag (1983). Antwort des Sozialministers auf die kline Anfrageder Abgeordneten Blaul, Kern, Kerschgens, Schilling und Treber (GRÜNE) betreffend Tierversuch in Hessen.Drucksache11, 54. Weisbaden: Hessischer Landtag.
29.
RossbachW. (1983). Grunde fuer die Abnahmedes Versuchstierbedarfs.Roche-Nachrichten7, 7–8.
30.
FreudigerU. (1985). Die Volksinitiative fuer die Abschaffung der Vivisektion.Schweizerisches Archw fuer Tierheilkunde127, 635–649.
31.
Home Office (1981). Statistics of Experiments on Living Animals in Great Britain 1980 (Cmnd 8301). London: Home Office.
